{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:26:26Z","timestamp":1768721186929,"version":"3.49.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>In early 2007, American pet food ingredients leading to nephrotoxic renal failure of dogs and cats raised serious concerns about the safety of pet foods. Major pet food companies recalled more than 1,000 commercial pet foods in consideration of pet safety. A similar pet food-associated outbreak of nephrotoxic renal failure occurred in Asia, in late 2003 and 2004, resulting in a similar extensive pet food recall. At that time, contamination of ingredients with a nephrotoxin-producing fungus at a pet food production facility was suspected. However, toxicologic evidence to substantiate a mycotoxicosis was lacking. Moreover, the renal lesions were not typical of those reported with fungal nephrotoxins. During 2003 and 2004, 14 dogs were presented to the Veterinary Medical Teaching Hospital of Konkuk University, Seoul, Korea, with renal failure and distinctive renal pathologic findings. Grossly, the kidneys were greenish in color with greenish uroliths in the renal pelvis or bladder. Histologically, characteristic crystals with pinwheel radiating striations were present in distal tubular segments. Toxicologic analysis identified melamine, cyanuric acid, and ammelide in deparaffinized formalin-fixed kidney samples.<\/jats:p>","DOI":"10.1354\/vp.46-2-348","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T09:03:55Z","timestamp":1236157435000},"page":"348-354","source":"Crossref","is-referenced-by-count":46,"title":["Retrospective Study of Melamine\/Cyanuric Acid-Induced Renal Failure in Dogs in Korea between 2003 and 2004"],"prefix":"10.1177","volume":"46","author":[{"given":"J.-Y.","family":"Yhee","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong Kwangjin-gu, Seoul 143-701, Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-H.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong Kwangjin-gu, Seoul 143-701, Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong Kwangjin-gu, Seoul 143-701, Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Poppenga","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, Toxicology Laboratory, University of California, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-H.","family":"Sur","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong Kwangjin-gu, Seoul 143-701, Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"bibr1-vp.46-2-348","unstructured":"1 Anonymous: March 15, 2004, Pedigree brand dog food recalled in Asia after illnesses reported. 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Available at: http:\/\/www.ctv. ca\/servlet\/ArticleNews\/story\/CTVNews\/20070427\/ petfood_guelph_070427\/20070427?hub=TopStories. Accessed May 9, 2008"},{"key":"bibr20-vp.46-2-348","volume-title":"Laboratory Method in Histotechnology","author":"Prophet EB","year":"1992"},{"key":"bibr21-vp.46-2-348","doi-asserted-by":"publisher","DOI":"10.1177\/104063870701900602"},{"key":"bibr22-vp.46-2-348","unstructured":"22 Swaminathan N: April 25, 2007, Were Our Pets Deliberately Poisoned? Scientific American. Available at: http:\/\/www.sciam.com\/article.cfm?articleID=2B10D1F6-E7F2-99DF-34DAAAC1622FE3CE&chanID=sa007. Accessed April 29, 2008"},{"key":"bibr23-vp.46-2-348","doi-asserted-by":"publisher","DOI":"10.1354\/vp.45-3-417"},{"key":"bibr24-vp.46-2-348","unstructured":"24 U.S. Food and Drug Administration. Pet Food Recall (Melamine)\/Tainted Animal Feed. Available at: http:\/\/www.fda.gov\/oc\/opacom\/hottopics\/petfood.html. 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