{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:05:27Z","timestamp":1773849927186,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Using magnetic resonance imaging, men with spinal cord injury (n = 10) were found to have fewer trabeculae that were spaced further apart in the knee than able-bodied controls of similar age, height, and weight (n = 8). The deteriorated trabecular bone microarchitecture may contribute to the increased fracture incidence after injury.<\/jats:p>\n               <jats:p>Introduction: Spinal cord injury results in a dramatic decline in areal bone mineral density (aBMD) and a marked increase in lower extremity fracture; however, its effect on trabecular bone microarchitecture is unknown. The purpose of this study was to determine if trabecular bone microarchitecture is deteriorated in the knee of men with long-term, complete spinal cord injury.<\/jats:p>\n               <jats:p>Materials and Methods: Apparent bone volume to total volume (appBV\/TV), trabecular number, (appTb.N), trabecular thickness (appTb.Th), and trabecular separation (appTb.Sp), measures of trabecular bone microarchitecture, were assessed in the distal femur and proximal tibia of men with long-term (&amp;gt;2 years) complete spinal cord injury (SCI; n = 10) and able-bodied controls (CON; n = 8) using high-resolution magnetic resonance imaging. Proximal tibia and arm aBMD were determined using DXA. Independent t-tests were used to assess group differences in anthropometrics and bone parameters. Pearson correlation analysis was used to assess the relationships among trabecular bone microarchitecture, aBMD, and time since injury.<\/jats:p>\n               <jats:p>Results: There were no group differences in age, height, or weight; however, the distal femur and proximal tibia of SCI had 27% and 20% lower appBV\/TV, 21% and 20% lower appTb.N, and 44% and 33% higher appTb.Sp, respectively (p &amp;lt; 0.05). The distal femur of SCI also had 8% lower appTb.Th (p &amp;lt; 0.05). Whereas arm aBMD was not different in the two groups, proximal tibia aBMD was 43% lower in SCI. In SCI and CON combined, aBMD was correlated with appBV\/TV (r = 0.62), appTb.N (r = 0.78), and appTb.Sp (r = \u22120.82) in the proximal tibia (p &amp;lt; 0.05). Time since injury was more strongly correlated with appTb.N (r = \u22120.54) and appTb.Sp (r = 0.56) than aBMD (r = \u22120.36) in the distal tibia, although none of the relationships were statistically significant (p &amp;gt; 0.05).<\/jats:p>\n               <jats:p>Conclusion: Men with complete spinal cord injury have markedly deteriorated trabecular bone microarchitecture in the knee, which may contribute to their increased fracture incidence.<\/jats:p>","DOI":"10.1359\/jbmr.0301208","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T05:58:24Z","timestamp":1146117504000},"page":"48-55","source":"Crossref","is-referenced-by-count":89,"title":["Trabecular Bone Microarchitecture Is Deteriorated in Men With Spinal Cord Injury"],"prefix":"10.1093","volume":"19","author":[{"given":"Christopher M","family":"Modlesky","sequence":"first","affiliation":[{"name":"Department of Exercise Science, The University of Georgia, Athens, Georgia, 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