{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T11:49:21Z","timestamp":1752666561668},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A case of bilateral femoral head osteonecrosis after septic shock is presented. We suggest that the osteonecrosis was caused by ischemic insults to the proximal femora. The association between septic shock and osteonecrosis has not been previously reported.<\/jats:p>\n               <jats:p>Introduction: Osteonecrosis is an uncommon disorder characterized by the in situ death of bone. A diverse range of conditions has been associated with osteonecrosis. We present a case of bilateral femoral head osteonecrosis that occurred after an episode of septic shock.<\/jats:p>\n               <jats:p>Materials and Methods: A 66-year-old woman presented with a left-sided renal stone and a urinary tract infection. Her condition rapidly progressed to a life-threatening illness with septic shock complicated by multiorgan failure, which necessitated prolonged intensive care and inotropic support. She made a full recovery but 3 months later developed bilateral osteonecrosis of the femoral heads requiring bilateral total hip joint replacement.<\/jats:p>\n               <jats:p>Results and Conclusions: We propose that the osteonecrosis was caused by ischemic insults to the femoral heads as a result of the widespread systemic ischemia that occurred during her initial illness. To our knowledge, septic shock has not been previously described as a cause of osteonecrosis. Clinicians should be aware of this association, particularly in patients presenting with bone pain after episodes of sepsis.<\/jats:p>","DOI":"10.1359\/jbmr.0301250","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T07:01:13Z","timestamp":1146121273000},"page":"517-520","source":"Crossref","is-referenced-by-count":16,"title":["Bilateral Femoral Head Osteonecrosis After Septic Shock and Multiorgan Failure"],"prefix":"10.1093","volume":"19","author":[{"given":"Mark J","family":"Bolland","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Auckland Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gill","family":"Hood","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Auckland Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja T","family":"Bastin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Middlemore Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R","family":"King","sequence":"additional","affiliation":[{"name":"Department of Pathology, Middlemore Hospital, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Grey","sequence":"additional","affiliation":[{"name":"Department of Medicine, Auckland University, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024013019212503100_bib1","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1055\/s-0037-1616068","article-title":"Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation","volume":"86","author":"Taylor","year":"2001","journal-title":"Thromb Haemost"},{"key":"2024013019212503100_bib2","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1056\/NEJM199205283262206","article-title":"Nontraumatic necrosis of bone","volume":"326","author":"Mankin","year":"1992","journal-title":"N Engl J Med"},{"key":"2024013019212503100_bib3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/sarh.2002.33724b","article-title":"Pathogenesis and natural history of osteonecrosis","volume":"32","author":"Assouline-Dayan","year":"2002","journal-title":"Semin Arthritis Rheum"},{"key":"2024013019212503100_bib4","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1001\/archinte.1996.00440120079007","article-title":"Antinuclear antibody testing. 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