{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:17:08Z","timestamp":1791026228600,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The osteogenic potential of short durations of low-level mechanical stimuli was examined in children with disabling conditions. The mean change in tibia vTBMD was +6.3% in the intervention group compared with \u221211.9% in the control group. This pilot randomized controlled trial provides preliminary evidence that low-level mechanical stimuli represent a noninvasive, non-pharmacological treatment of low BMD in children with disabling conditions.<\/jats:p>\n               <jats:p>Introduction: Recent animal studies have demonstrated the anabolic potential of low-magnitude, high-frequency mechanical stimuli to the trabecular bone of weight-bearing regions of the skeleton. The main aim of this prospective, double-blind, randomized placebo-controlled pilot trial (RCT) was to examine whether these signals could effectively increase tibial and spinal volumetric trabecular BMD (vTBMD; mg\/ml) in children with disabling conditions.<\/jats:p>\n               <jats:p>Materials and Methods: Twenty pre-or postpubertal disabled, ambulant, children (14 males, 6 females; mean age, 9.1 \u00b1 4.3 years; range, 4\u201319 years) were randomized to standing on active (n = 10; 0.3g, 90 Hz) or placebo (n = 10) devices for 10 minutes\/day, 5 days\/week for 6 months. The primary outcomes of the trial were proximal tibial and spinal (L2) vTBMD (mg\/ml), measured using 3-D QCT. Posthoc analyses were performed to determine whether the treatment had an effect on diaphyseal cortical bone and muscle parameters.<\/jats:p>\n               <jats:p>Results and Conclusions: Compliance was 44% (4.4 minutes per day), as determined by mean time on treatment (567.9 minutes) compared with expected time on treatment over the 6 months (1300 minutes). After 6 months, the mean change in proximal tibial vTBMD in children who stood on active devices was 6.27 mg\/ml (+6.3%); in children who stood on placebo devices, vTBMD decreased by \u22129.45 mg\/ml (\u221211.9%). Thus, the net benefit of treatment was +15.72 mg\/ml (17.7%; p = 0.0033). In the spine, the net benefit of treatment, compared with placebo, was +6.72 mg\/ml, (p = 0.14). Diaphyseal bone and muscle parameters did not show a response to treatment. The results of this pilot RCT have shown for the first time that low-magnitude, high-frequency mechanical stimuli are anabolic to trabecular bone in children, possibly by providing a surrogate for suppressed muscular activity in the disabled. Over the course of a longer treatment period, harnessing bone's sensitivity to these stimuli may provide a non-pharmacological treatment for bone fragility in children.<\/jats:p>","DOI":"10.1359\/jbmr.040129","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T07:01:13Z","timestamp":1146121273000},"page":"360-369","source":"Crossref","is-referenced-by-count":314,"title":["Low Magnitude Mechanical Loading Is Osteogenic in Children With Disabling Conditions"],"prefix":"10.1093","volume":"19","author":[{"given":"Kate","family":"Ward","sequence":"first","affiliation":[{"name":"Clinical Radiology, Imaging Science & Biomedical Engineering, University of Manchester, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrissie","family":"Alsop","sequence":"additional","affiliation":[{"name":"Clinical Radiology, Imaging Science & Biomedical Engineering, University of Manchester, Manchester, United 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