{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:37:46Z","timestamp":1710376666367},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We describe two female patients, 66 and 36 years of age, with both primary hyperparathyroidism and chondrosarcoma. Case 1 had a chondrosarcoma of the right scapula, and case 2 had chondrosarcoma of the left proximal tibia. Both patients underwent surgical resection of their chondrosarcoma and subsequent parathyroid surgery. Histological analysis of the excised parathyroid in case 1 showed a parathyroid carcinoma and in case 2 showed a parathyroid adenoma. Including these two patients, there is now a total of six cases that have been reported in the literature describing the association between hyperparathyroidism and bone malignancy. We believe that this small number makes it unlikely that there is an association between these two conditions, although we speculate that there may be an underlying genetic basis.<\/jats:p>","DOI":"10.1359\/jbmr.040317","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:24:04Z","timestamp":1146097444000},"page":"1200-1203","source":"Crossref","is-referenced-by-count":4,"title":["Chondrosarcoma in Association With Primary Hyperparathyroidism"],"prefix":"10.1093","volume":"19","author":[{"given":"Ajay","family":"Bhatia","sequence":"first","affiliation":[{"name":"The Metabolic Bone Disease Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Cannon","sequence":"additional","affiliation":[{"name":"London Bone Tumour Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Briggs","sequence":"additional","affiliation":[{"name":"Department of Medicine, University College London, Center for Rheumatology, London, United Kingdom"},{"name":"The Metabolic Bone Disease Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W","family":"Keen","sequence":"additional","affiliation":[{"name":"London Bone Tumour Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024013019201118000_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/01926230252929882","article-title":"Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone(1\u201334) for 2 years and relevance to human safety","volume":"30","author":"Vahle","year":"2002","journal-title":"Toxicol Pathol"},{"key":"2024013019201118000_bib2","first-page":"391","article-title":"Hyperparathyroidism with multiple malignant tumors of bone with giant cells","volume":"137","author":"Wiig","year":"1971","journal-title":"Acta Chir Scand"},{"key":"2024013019201118000_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s002560050202","article-title":"Hyperparathyroidism associated with sarcoma of bone","volume":"26","author":"Smith","year":"1997","journal-title":"Skeletal Radiol"},{"key":"2024013019201118000_bib4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1359\/jbmr.2003.18.1.163","article-title":"Osteosarcoma of bone in a patient with primary hyperparathyroidism: A case report","volume":"18","author":"Betancourt","year":"2003","journal-title":"J Bone Miner Res"},{"key":"2024013019201118000_bib5","first-page":"425","volume-title":"Radiology of Bone Diseases","author":"Greenfield","year":"1975","edition":"2nd ed."},{"key":"2024013019201118000_bib6","first-page":"N18","article-title":"Epidemiology of primary hyperparathyroidism in Europe","volume":"17","author":"Adami","year":"2002","journal-title":"J Bone Miner Res"},{"key":"2024013019201118000_bib7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7326\/0003-4819-126-6-199703150-00003","article-title":"The rise and fall of primary hyperparathyroidism: A population-based study in Rochester, Minnesota, 1965\u20131992","volume":"126","author":"Wermers","year":"1997","journal-title":"Ann Intern Med"},{"key":"2024013019201118000_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/1097-0142(19950101)75:1+<203::AID-CNCR2820751308>3.0.CO;2-V","article-title":"Bone cancers","volume":"75","author":"Dorfman","year":"1995","journal-title":"Cancer"},{"key":"2024013019201118000_bib9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng844","article-title":"A mutant PTH\/PTHrP type I receptor in enchondromatosis","volume":"30","author":"Hopyan","year":"2002","journal-title":"Nat Genet"},{"key":"2024013019201118000_bib10","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/cncr.10846","article-title":"Hyperparathyroidism and subsequent cancer risk in Denmark","volume":"95","author":"Pickard","year":"2002","journal-title":"Cancer"},{"key":"2024013019201118000_bib11","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1\u201334) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"244","author":"Neer","year":"2001","journal-title":"N Engl J Med"},{"key":"2024013019201118000_bib12","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1359\/jbmr.2002.17.7.1151","article-title":"Commentary on clinical safety of recombinant human parathyroid hormone 1\u201334 in the treatment of osteoporosis in men and postmenopausal women","volume":"17","author":"Tashian","year":"2002","journal-title":"J Bone Miner Res"},{"key":"2024013019201118000_bib13","article-title":"Dose and treatment duration are key factors in the development of bone neoplasms in F344 rats given teriparatide [rhPTH(1\u201334)]","author":"Vahle","year":"2004","journal-title":"J Bone Miner Res"},{"key":"2024013019201118000_bib14","article-title":"Primary hyperparathyroidism and osteosarcoma: Examination of a large osteosarcoma cohort identifies unique characteristics","author":"Jimenez","year":"2004","journal-title":"J Bone Miner Res"},{"key":"2024013019201118000_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1098-2264(199606)16:2<138::AID-GCC8>3.0.CO;2-0","article-title":"Frequent loss of heterozygosity for markers on chromosome arm 10q in chondrosarcomas","volume":"16","author":"Raskind","year":"1996","journal-title":"Genes Chromosomes Cancer"},{"key":"2024013019201118000_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1507\/endocrj.42.527","article-title":"Mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A (Sipple's syndrome)","volume":"42","author":"Oishi","year":"1995","journal-title":"Endocr J"},{"key":"2024013019201118000_bib17","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/BF03343875","article-title":"Clinical genetics of multiple endocrine neoplasias, Carney complex and related syndromes","volume":"24","author":"Stratakis","year":"2001","journal-title":"J Endocrinol Invest"},{"key":"2024013019201118000_bib18","first-page":"2711","article-title":"Role of RET proto-oncogene in sporadic hyperparathyroidism and in hyperparathyroidism of multiple endocrine neoplasia type 2","volume":"81","author":"Pausova","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013019201118000_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1046\/j.1365-2265.1997.3421147.x","article-title":"Metastatic parathyroid carcinoma in the MEN 2A syndrome","volume":"47","author":"Jenkins","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2024013019201118000_bib20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1096-9896(199610)180:2<138::AID-PATH652>3.0.CO;2-H","article-title":"Analysis of the RET proto-oncogene in sporadic parathyroid adenomas","volume":"180","author":"Williams","year":"1996","journal-title":"J Pathol"},{"key":"2024013019201118000_bib21","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1056\/NEJMoa031237","article-title":"Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma","volume":"349","author":"Shattuck","year":"2003","journal-title":"N Engl J Med"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1359%2FJBMR.040317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/19\/7\/1200\/56475386\/5650190720.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/19\/7\/1200\/56475386\/5650190720.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:06:49Z","timestamp":1710342409000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/19\/7\/1200-1203\/7592857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":21,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2009,12,2]]},"published-print":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1359\/jbmr.040317","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,7,1]]},"published":{"date-parts":[[2004,7,1]]}}}