{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:04:02Z","timestamp":1775495042305,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The pregnancies of two women with osteogenesis imperfecta who received intravenous pamidronate before conception are reported. The mothers suffered no ill effects. One baby had transient asymptomatic hypocalcemia and one had bilateral talipes equinovarus.<\/jats:p>\n               <jats:p>This report documents the pregnancy outcomes of two women with osteogenesis imperfecta (OI), types I and IV, who received intravenous pamidronate as part of an observational trial before conception. Pamidronate was not administered after conception. Other than hyperemesis in one woman, the pregnancies and deliveries were uneventful. Both babies inherited OI from their mothers. The baby with OI type IV also had bilateral talipes equinovarus. Biochemical evaluation of the mothers and babies at 24 h and\/or 2 weeks postpartum was normal, apart from one baby with asymptomatic hypocalcemia at 24 h of age that had resolved when next measured on day 11 of life. No biochemistry was available on the second child until 13 days of age. Neither baby had skeletal modeling abnormalities consistent with in utero pamidronate exposure. The lumbar spine (L1-L4) areal BMD and anterior to posterior height ratios of lumbar vertebral bodies of both women remained constant during pregnancy. Both the mothers and babies remain well and free of fracture 14 and 16 months postpartum.<\/jats:p>","DOI":"10.1359\/jbmr.040711","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T06:03:46Z","timestamp":1146117826000},"page":"1742-1745","source":"Crossref","is-referenced-by-count":99,"title":["Maternal and Fetal Outcome After Long-Term Pamidronate Treatment Before Conception: A Report of Two Cases"],"prefix":"10.1093","volume":"19","author":[{"given":"Craig FJ","family":"Munns","sequence":"first","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Rauch","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Ward","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis H","family":"Glorieux","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024013019184153900_bib1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis imperfecta","volume":"363","author":"Rauch","year":"2004","journal-title":"Lancet"},{"key":"2024013019184153900_bib2","first-page":"654","article-title":"Reproduction toxicity studies with pamidronate","volume":"42","author":"Graepel","year":"1992","journal-title":"Arzneimittelforschung"},{"key":"2024013019184153900_bib3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1056\/NEJMp038103","article-title":"Do bisphosphonates make children's bones better or brittle?","volume":"349","author":"Marini","year":"2003","journal-title":"N Engl J Med"},{"key":"2024013019184153900_bib4","first-page":"87","article-title":"The effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) on fetal mice during pregnancy\u2014with emphasis on implantation and fetal weight","volume":"19","author":"Sakiyama","year":"1985","journal-title":"J Osaka Dent Univ"},{"key":"2024013019184153900_bib5","first-page":"91","article-title":"The effect of ethane-1-hydroxy-1, 1-diphosphonate (EHDP) on fetal mice during pregnancy. 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