{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:33:55Z","timestamp":1791023635496,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infrared imaging analysis of iliac crest biopsy specimens from patients with osteoporotic and multiple spontaneous fractures shows significant differences in the spatial variation of the nonreducible:reducible collagen cross-links at bone-forming trabecular surfaces compared with normal bone.<\/jats:p>\n                  <jats:p>Introduction: Although the role of BMC and bone mineral quality in determining fracture risk has been extensively studied, considerably less attention has been paid to the quality of collagen in fragile bone.<\/jats:p>\n                  <jats:p>Materials and Methods: In this study, the technique of Fourier transform infrared imaging (FTIRI) was used to determine the ratio of nonreducible:reducible cross-links, in 2- to 4-\u03bcm-thick sections, from human iliac crest biopsy specimens (N = 27) at bone-forming trabecular surfaces. The biopsy specimens were obtained from patients that had been diagnosed as high- or low-turnover osteoporosis, as well as premenopausal women &amp;lt;40 years of age, with normal BMD and biochemistry, who suffered multiple spontaneous fractures. The obtained values were compared with previously published analyses of trabecular bone from normal non-osteoporotic subjects (N = 14, 6 males and 8 females; age range, 51\u201370 years).<\/jats:p>\n                  <jats:p>Results and Conclusions: Collagen cross-links distribution within the first 50 \u03bcm at forming trabecular surfaces in patients with fragile bone was markedly different compared with normal bone.<\/jats:p>","DOI":"10.1359\/jbmr.040820","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T02:05:46Z","timestamp":1146103546000},"page":"2000-2004","source":"Crossref","is-referenced-by-count":230,"title":["Bone Fragility and Collagen Cross-Links"],"prefix":"10.1093","volume":"19","author":[{"given":"Eleftherios P","family":"Paschalis","sequence":"first","affiliation":[{"name":"Ludwig Boltzmann Institut f\u00fcr Osteologie im Hanusch-Krankenhaus der WGKK and Unfallkrankenhaus Meidling der AUVA4, Medizinische Abteilung, Vienna, Austria"},{"name":"Mineralized Tissue Division, Hospital for Special Surgery, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shane","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Lyritis","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigoris","family":"Skarantavos","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mendelsohn","sequence":"additional","affiliation":[{"name":"Chemistry Department, Rutgers University, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele L","family":"Boskey","sequence":"additional","affiliation":[{"name":"Mineralized Tissue Division, Hospital for Special Surgery, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024013019181429300_bib1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/8756-3282(93)90209-S","article-title":"Cortical aging differences and fracture implications for the human femoral neck","volume":"14","author":"Boyce","year":"1993","journal-title":"Bone"},{"key":"2024013019181429300_bib2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/bmj.312.7041.1254","article-title":"Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures","volume":"312","author":"Marshall","year":"1996","journal-title":"BMJ"},{"key":"2024013019181429300_bib3","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0002-9343(85)90343-2","article-title":"Are patients with hip fractures more osteoporotic? 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