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Laboratory results showed no gross abnormalities. Radiological imaging including conventional X-ray, MRI scans, and 3D CT reconstruction of the rib cage revealed circumscript destruction of the left lateral ribs 9\u201311. Histological analysis of a rib biopsy showed angiomatous hypervascularization and intracortical fibrosis. In keeping with these findings, the patient's condition was diagnosed as Gorham-Stout disease, a rare condition with localized, often unilateral, bone destruction. Monotherapy with bisphosphonates (pamidronate 30 mg IV every 3 months) was initiated, leading to rapid disappearance of local pain. Follow-up over 24 months documented a stable clinical and radiological picture without evidence of progressive bone destruction.<\/jats:p>","DOI":"10.1359\/jbmr.041113","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:31:36Z","timestamp":1146097896000},"page":"350-353","source":"Crossref","is-referenced-by-count":91,"title":["Gorham-Stout Disease\u2014Stabilization During Bisphosphonate Treatment"],"prefix":"10.1093","volume":"20","author":[{"given":"Fabian","family":"Hammer","sequence":"first","affiliation":[{"name":"Department of Medicine, Endocrine and Diabetes Unit, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Kenn","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Wesselmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz C","family":"Hofbauer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Endocrinology and Metabolism, University of Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Delling","sequence":"additional","affiliation":[{"name":"Department of Bone Pathology, University of Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Allolio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrine and Diabetes Unit, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Arlt","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024013019225136300_bib1","first-page":"368","article-title":"A boneless arm","volume":"18","author":"Jackson","year":"1838","journal-title":"Boston Med Surg J"},{"key":"2024013019225136300_bib2","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2106\/00004623-195537050-00008","article-title":"Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone): Its relation to hemangiomatosis","volume":"37","author":"Gorham","year":"1955","journal-title":"J Bone Joint Surg Am"},{"key":"2024013019225136300_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1046\/j.1365-2265.2003.01969.x","article-title":"Effects of oral contraceptives on circulating osteoprotegerin and soluble RANK ligand serum levels in healthy young women","volume":"60","author":"Hofbauer","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2024013019225136300_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1302\/0301-620X.67B1.3968152","article-title":"The syndrome of idiopathic osteolysis","volume":"67","author":"Hardegger","year":"1985","journal-title":"Classification, review, and case report. 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