{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:00:23Z","timestamp":1790935223506,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In an effort to identify genetic polymorphisms in potential candidate genes for osteoporosis, 10 variants were identified in the OSCAR gene using direct DNA sequencing, and 560 postmenopausal women were genotyped at five SNP loci, using the TaqMan method. The rare allele (G allele) of OSCAR-2322A&amp;gt;G (SNP in the 5\u2032 flanking region) showed significant association with lower BMD at various bone sites in postmenopausal women (n = 560).<\/jats:p>\n               <jats:p>Introduction: BMD is the major factor for determining bone strength and osteoporotic fracture risk and is determined by both environmental and multiple genetic factors. The osteoclast-associated receptor (OSCAR) plays a critical role in osteoclast differentiation and thus is an important candidate gene for the modulation of BMD.<\/jats:p>\n               <jats:p>Materials and Methods: Through direct sequencing in 24 Korean individuals, 10 sequence variants were identified: 2 in the 5\u2032 flanking region, 7 in the exons (including 6 nonsynonymous single-nucleotide polymorphisms [SNPs]), and 1 in an intron. Five of these polymorphisms were selected for larger-scale genotyping in postmenopausal women (n = 560). Areal BMD (g\/cm2) of the anterior-posterior lumbar spine and the nondominant proximal femur was measured using DXA (Lunar Expert XL and Hologic QDR 4500-A). Lateral thoracolumbar radiographs were obtained in all subjects.<\/jats:p>\n               <jats:p>Results: Using multiple regression analysis and controlling for age, years since menopause, height, weight, and evaluation machine as covariates, the rare allele (G allele) of OSCAR-2322A&amp;gt;G showed significant association with lower BMD at various bone sites in postmenopausal women.<\/jats:p>\n               <jats:p>Conclusion: These findings suggest that the promoter variant in OSCAR gene (OSCAR-2322A&amp;gt;G) might be one of genetic determinants of BMD in postmenopausal women.<\/jats:p>","DOI":"10.1359\/jbmr.050320","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T09:06:25Z","timestamp":1146128785000},"page":"1342-1348","source":"Crossref","is-referenced-by-count":39,"title":["Association of the <i>OSCAR<\/i> Promoter Polymorphism With BMD in Postmenopausal Women"],"prefix":"10.1093","volume":"20","author":[{"given":"Ghi Su","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Min","family":"Koh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Suk","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Lae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyoung Hyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung Doo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Republic of 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