{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:14:48Z","timestamp":1790183688806,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To study effects of loop diuretics on bone, 87 women were randomized to 1 year of treatment with bumetanide or placebo. Compared with placebo, bumetanide decreased BMD by 2% at the total hip and by 1.4% at the whole body. Levels of biochemical bone markers were lower in the placebo than in the bumetanide group. Thus, treatment with loop diuretics affects bone metabolism.<\/jats:p><jats:p>Introduction: Loop diuretics may affect bone because they increase the renal calcium excretion and alters the diurnal rhythm of plasma PTH levels. We studied the effects of 1 year of treatment with the loop diuretic bumetanide on bone metabolism.<\/jats:p><jats:p>Materials and Methods: In a double-blinded design, 87 healthy postmenopausal women with osteopenia were randomized to 1-year bumetanide treatment 2 mg\/day or placebo. BMD, plasma levels of calcitropic hormones, and biochemical bone markers were measured at baseline, after 1 year of treatment (week 52), and 6 months after withdrawal of treatment (week 78). Calcium (800 mg\/day) and vitamin D (10 \u03bcg\/day) were administered to all participants during the entire 1.5-year study period.<\/jats:p><jats:p>Results: Compared with placebo, urinary calcium (+17%) and plasma PTH levels (+9%) increased significantly in response to bumetanide. After 1 year of treatment, BMD in the bumetanide compared with the placebo group was significantly decreased by 2% at the total hip and ultradistal forearm and by 1.4% at the whole body. In addition, levels of biochemical markers of bone turnover differed significantly (\u223c20%) between groups, with lower levels in the placebo than in the bumetanide group. Six months after the end of treatment, the effects of bumetanide were weakening.<\/jats:p><jats:p>Conclusions: Treatment with loop diuretics affects bone turnover and decreases BMD. Further studies may reveal whether loop diuretics should be considered as a risk factor for fracture.<\/jats:p>","DOI":"10.1359\/jbmr.051003","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T13:27:09Z","timestamp":1146058029000},"page":"163-170","source":"Crossref","is-referenced-by-count":104,"title":["Loop Diuretics Increase Bone Turnover and Decrease BMD in Osteopenic Postmenopausal Women: Results From a Randomized Controlled Study With Bumetanide"],"prefix":"10.1093","volume":"21","author":[{"given":"Lars","family":"Rejnmark","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"},{"name":"Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"},{"name":"Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Heickendorff","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Mosekilde","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Aarhus University, Aarhus, Denmark"},{"name":"Department of Endocrinology and Metabolism C, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024013019400364200_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000183290","article-title":"Effects of oral furosemide and salt loading on parathyroid function in normal subjects","volume":"38","author":"Fujita","year":"1984","journal-title":"Nephron"},{"key":"2024013019400364200_bib2","first-page":"8","article-title":"Furosemide therapy and intact parathyroid hormone plasma concentrations in chronic renal insufficiency","volume":"7","author":"Reichel","year":"1992","journal-title":"Nephrol Dial Transplant"},{"key":"2024013019400364200_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1172\/JCI107156","article-title":"Evidence for secondary hyperparathyroidism in idiopathic hypercalciuria","volume":"52","author":"Coe","year":"1973","journal-title":"J Clin Invest"},{"key":"2024013019400364200_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2362.2003.01103.x","article-title":"Dose-effect relations of loop- and thiazide-diuretics on calcium homeostasis: A randomized, double-blinded Latin-square multiple cross-over study in postmenopausal osteopenic women","volume":"33","author":"Rejnmark","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"2024013019400364200_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0169-6009(08)80119-5","article-title":"Thiazides and seasonal bone change in healthy postmenopausal women","volume":"21","author":"Dawson Hughes","year":"1993","journal-title":"Bone Miner"},{"key":"2024013019400364200_bib6","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/oxfordjournals.aje.a116954","article-title":"Thiazides and bone mineral density in elderly men and women","volume":"139","author":"Morton","year":"1994","journal-title":"Am J Epidemiol"},{"key":"2024013019400364200_bib7","first-page":"457","article-title":"Differential effects of thiazide and estrogen upon bone mineral content and fracture prevalence","volume":"67","author":"Wasnich","year":"1986","journal-title":"Obstet Gynecol"},{"key":"2024013019400364200_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7326\/0003-4819-133-7-200010030-00010","article-title":"Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults. 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