{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:52:36Z","timestamp":1782964356484,"version":"3.54.5"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This analysis of 50 growing patients with osteogenesis imperfecta revealed that 2-4 years of pamidronate treatment lead to abnormalities in the shape of the distal femoral metaphyses.<\/jats:p>\n               <jats:p>Introduction: Cyclical intravenous pamidronate therapy is of clinical benefit in children and adolescents with moderate to severe osteogenesis imperfecta (OI) but might interfere with the shaping of long bone metaphyses during growth.<\/jats:p>\n               <jats:p>Materials and Methods: We evaluated the distal femur in 50 growing children with moderate to severe OI (mean age, 6.7 \u00b1 3.4 years; 26 girls) who had received 2-4 years of pamidronate therapy (annual dose, 9 mg\/kg body weight). The mediolateral width of the distal femoral growth plate and of the metaphysis, as well as the ratio between these two measures (called metaphyseal index), were determined on lower limb radiographs.<\/jats:p>\n               <jats:p>Results: Compared with untreated OI patients who were matched for OI type and age, pamidronate-treated patients had similar growth plate width but wider metaphyses, resulting in a 26% higher metaphyseal index (p &amp;lt; 0.001). Apart from the effect on bone shape, each pamidronate cycle induces a transverse line in metaphyses that are adjacent to active growth plates. Analyses of these transverse lines revealed that they persist for an average time of \u223c4 years, with a range from 2 to 8 years.<\/jats:p>\n               <jats:p>Conclusions: Pamidronate interferes with the process of periosteal resorption that is normally responsible for shaping the distal femoral metaphysis. Pamidronate-induced transverse lines disappear with time, supporting the view that these lines represent horizontal trabeculae that undergo remodeling. There is no evidence at present that these treatment induced morphological changes have any clinical implications.<\/jats:p>","DOI":"10.1359\/jbmr.051207","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T13:26:15Z","timestamp":1146057975000},"page":"374-379","source":"Crossref","is-referenced-by-count":72,"title":["Cyclical Intravenous Pamidronate Treatment Affects Metaphyseal Modeling in Growing Patients With Osteogenesis Imperfecta"],"prefix":"10.1093","volume":"21","author":[{"given":"Christof","family":"Land","sequence":"first","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children and McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Rauch","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children and McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis H","family":"Glorieux","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children and McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024013019392983900_bib1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis imperfecta","volume":"363","author":"Rauch","year":"2004","journal-title":"Lancet"},{"key":"2024013019392983900_bib2","first-page":"194","article-title":"Bone growth in length and width: The Yin and Yang of bone stability","volume":"5","author":"Rauch","year":"2005","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"2024013019392983900_bib3","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Baron","year":"2003","edition":"5th ed."},{"key":"2024013019392983900_bib4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/BF02555748","article-title":"Quantitative morphometric evaluation of the inhibitory activity of new aminobisphosphonates on bone resorption in the rat","volume":"38","author":"Schenk","year":"1986","journal-title":"Calcif Tissue Int"},{"key":"2024013019392983900_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJMoa023110","article-title":"Bisphosphonate-induced osteopetrosis","volume":"349","author":"Whyte","year":"2003","journal-title":"N Engl J Med"},{"key":"2024013019392983900_bib6","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.bone.2005.02.016","article-title":"Quantification of metaphyseal modeling in children treated with bisphosphonates","volume":"36","author":"Ward","year":"2005","journal-title":"Bone"},{"key":"2024013019392983900_bib7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00247-003-0865-1","article-title":"Radiographic features of bisphosphonate therapy in pediatric patients","volume":"33","author":"Grissom","year":"2003","journal-title":"Pediatr Radiol"},{"key":"2024013019392983900_bib8","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1359\/JBMR.040303","article-title":"Sclerotic metaphyseal lines in a child treated with pamidronate: Histomorphometric analysis","volume":"19","author":"Rauch","year":"2004","journal-title":"J Bone Miner Res"},{"key":"2024013019392983900_bib9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/35015116","article-title":"Effects of mechanical forces on maintenance and adaptation of form in trabecular bone","volume":"405","author":"Huiskes","year":"2000","journal-title":"Nature"},{"key":"2024013019392983900_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1542\/peds.109.1.45","article-title":"Centers for Disease Control and Prevention 2000 growth charts for the United States: Improvements to the 1977 National Center for Health Statistics version","volume":"109","author":"Ogden","year":"2002","journal-title":"Pediatrics"},{"key":"2024013019392983900_bib11","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1651-2227.1992.tb12152.x","article-title":"Lumbar bone mineral content measured by dual energy X-ray absorptiometry in newborns and infants","volume":"81","author":"Salle","year":"1992","journal-title":"Acta Paediatr"},{"key":"2024013019392983900_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S8756-3282(99)00257-4","article-title":"Normative data for iliac bone histomorphometry in growing children","volume":"26","author":"Glorieux","year":"2000","journal-title":"Bone"},{"key":"2024013019392983900_bib13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: Standardization of nomenclature, symbols, and units. 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