{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:33:58Z","timestamp":1791023638389,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Strontium ranelate (2 g\/day) was studied in 5082 postmenopausal women. A reduction in incident vertebral fracture risk by 40% was shown after 3 years. This effect was independent of age, initial BMD, and prevalent vertebral fractures.<\/jats:p>\n               <jats:p>Introduction: Strontium ranelate is an orally active treatment able to decrease the risk of vertebral and hip fractures in osteoporotic postmenopausal women. The aim of this study was to assess the efficacy of strontium ranelate according to the main determinants of vertebral fracture risk: age, baseline BMD, prevalent fractures, family history of osteoporosis, baseline BMI, and addiction to smoking.<\/jats:p>\n               <jats:p>Materials and Methods: We pooled data of two large multinational randomized double-blind studies with a population of 5082 (2536 receiving strontium ranelate 2 g\/day and 2546 receiving a placebo), 74 years of age on average, and a 3-year follow-up. An intention-to-treat principle was used, as well as a Cox model for comparison and relative risks.<\/jats:p>\n               <jats:p>Results: The treatment decreased the risk of both vertebral (relative risk [RR] = 0.60 [0.53\u20130.69] p &amp;lt; 0.001) and nonvertebral (RR = 0.85 [0.74\u20130.99] p = 0.03) fractures. The decrease in risk of vertebral fractures was 37% (p = 0.003) in women &amp;lt;70 years, 42% (p &amp;lt; 0.001) for those 70\u201380 years of age, and 32% (p = 0.013) for those \u226580 years. The RR of vertebral fracture was 0.28 (0.07\u20130.99) in osteopenic and 0.61 (0.53\u20130.70) in osteoporotic women, and baseline BMD was not a determinant of efficacy. The incidence of vertebral fractures in the placebo group increased with the number of prevalent vertebral fractures, but this was not a determinant of the effect of strontium ranelate. In 2605 patients, the risk of experiencing a first vertebral fracture was reduced by 48% (p &amp;lt; 0.001). The risk of experiencing a second vertebral fracture was reduced by 45% (p &amp;lt; 0.001; 1100 patients). Moreover, the risk of experiencing more than two vertebral fractures was reduced by 33% (p &amp;lt; 0.001; 1365 patients). Family history of osteoporosis, baseline BMI, and addiction to smoking were not determinants of efficacy.<\/jats:p>\n               <jats:p>Conclusions: This study shows that a 3-year treatment with strontium ranelate leads to antivertebral fracture efficacy in postmenopausal women independently of baseline osteoporotic risk factors.<\/jats:p>","DOI":"10.1359\/jbmr.060101","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T08:53:43Z","timestamp":1146128023000},"page":"536-542","source":"Crossref","is-referenced-by-count":113,"title":["Vertebral Fracture Risk Reduction With Strontium Ranelate in Women With Postmenopausal Osteoporosis Is Independent of Baseline Risk Factors"],"prefix":"10.1093","volume":"21","author":[{"given":"Christian","family":"Roux","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Descartes, Facult\u00e9 de M\u00e9decine, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Cochin, Service de Rhumatologie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Reginster","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Public Health and Health Economics, University of Li\u00e8ge, Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Fechtenbaum","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Descartes, Facult\u00e9 de M\u00e9decine, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Cochin, Service de Rhumatologie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Kolta","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Descartes, Facult\u00e9 de M\u00e9decine, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Cochin, Service de Rhumatologie, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Sawicki","sequence":"additional","affiliation":[{"name":"Warsawian Center of Osteoporosis and Calcium Metabolism, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Tulassay","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Semmelweis Medical University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Luisetto","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Mediche e Chirurgiche, Universita Degli Studi Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Maria","family":"Padrino","sequence":"additional","affiliation":[{"name":"Servicio de Reumatologia, Hospital 12 de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Doyle","sequence":"additional","affiliation":[{"name":"Consultant and Hon Reader in Rheumatology, Whipps Cross University Hospital, Chingford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sir Charles Gairdner Hospital, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Fardellone","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Nord Hospital, Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Helmer","family":"Sorensen","sequence":"additional","affiliation":[{"name":"The Osteoporosis Research Center, Department 545, Hvidovre University Hospital, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Jean","family":"Meunier","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024013019391610200_bib1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"2024013019391610200_bib2","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0140-6736(96)07088-2","article-title":"Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. 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