{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:38:29Z","timestamp":1791639509195,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To determine if replacement of GH improves BMD in adult-onset GHD, we administered GH in physiologic amounts to men and women with GHD. GH replacement significantly increased spine BMD in the men by 3.8%.<\/jats:p>\n               <jats:p>Introduction: Growth hormone (GH) deficiency (GHD) acquired in adulthood results in diminished BMD; the evidence that replacement of GH improves BMD is not conclusive. We therefore performed a randomized, placebo-controlled trial to determine whether GH replacement would increase lumbar spine BMD in a combined group of men and women with adult-onset GHD.<\/jats:p>\n               <jats:p>Materials and Methods: We randomized 67 men and women to receive GH (n = 33) or placebo (n = 34) for 2 yr. The GH dose was initially 2 \u03bcg\/kg body weight\/d, increased gradually to a maximum of 12 \u03bcg\/kg\/d and adjusted to maintain a normal IGF-I concentration for age and sex. BMD was assessed before treatment and at 6, 12, 18, and 24 mo of treatment. Fifty-four subjects completed the protocol.<\/jats:p>\n               <jats:p>Results: BMD of the lumbar spine in the entire group increased by 2.9 \u00b1 3.9% above baseline in the GH-treated subjects, which was significantly (p = 0.037) greater than the 1.4 \u00b1 4.5% increase in the placebo-treated subjects. In a secondary analysis, spine BMD in GH-treated men increased 3.8 \u00b1 4.3% above baseline, which was significantly (p = 0.001) greater than that in placebo-treated men (0.4 \u00b1 4.7%), but the change in GH-treated women was not significantly different from that in placebo-treated women. Treatment with GH did not increase total hip BMD more than placebo treatment after 2 yr.<\/jats:p>\n               <jats:p>Conclusions: We conclude that GH replacement in men who have adult-onset GHD improves their spine BMD, but we cannot draw any conclusions about the effect of GH replacement on spine BMD in women with adult-onset GHD.<\/jats:p>","DOI":"10.1359\/jbmr.070205","type":"journal-article","created":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T20:09:06Z","timestamp":1170706146000},"page":"762-770","source":"Crossref","is-referenced-by-count":37,"title":["Effect of Growth Hormone Replacement on BMD in Adult-Onset Growth Hormone Deficiency"],"prefix":"10.1093","volume":"22","author":[{"given":"Peter J","family":"Snyder","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly MK","family":"Biller","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Zagar","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivor","family":"Jackson","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown Medical School, Providence, Rhode Island, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha M","family":"Arafah","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd B","family":"Nippoldt","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Oregon Health Sciences University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshag D","family":"Mooradian","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, St Louis University, St Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kwan","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Scism-Bacon","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Chipman","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L","family":"Hartman","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319312125500_bib1","first-page":"669","article-title":"Reduced bone mineral density in patients with adult onset growth hormone deficiency","volume":"78","author":"Holmes","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2024020319312125500_bib2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1530\/eje.0.1330180","article-title":"Reduced bone mineral density in adults with growth hormone (GH) deficiency: Increased bone turnover during 12 months of GH 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