{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:07:30Z","timestamp":1791022050706,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Elevated serum IGFBP-2 is associated with lower BMD in men and women. It is unknown whether IGFBP-2 serves as a negative regulator of bone metabolism by decreasing bone formation or increasing bone resorption. Studying an age-stratified community-based sample of 344 men and 276 women, IGFBP-2 was the strongest predictor of increased bone resorption among the IGF\/IGFBPs studied.<\/jats:p>\n               <jats:p>Introduction: Serum insulin-like growth factor binding protein-2 (IGFBP-2), which increases with age, is a predictor of low BMD among aging men and women. However, it is unknown whether IGFBP-2 negatively influences bone metabolism by decreasing bone formation or increasing bone resorption. Few have examined the relation between the insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) with bone turnover markers.<\/jats:p>\n               <jats:p>Materials and Methods: In an age-stratified, random sample of the community, we examined the association between serum IGF-I, IGF-II, IGFBP-1, \u22122, and \u22123, and bone turnover markers before and after adjustment for potential confounders (age, body mass index, bioavailable estradiol and testosterone, and sex hormone binding globulin). Analyses were stratified by sex and menopausal status.<\/jats:p>\n               <jats:p>Results: We studied 344 men (age range, 23\u201390 yr) and 276 women (age range, 21\u201393 yr; 166 postmenopausal) not on oral contraceptives or hormone replacement. Among the IGF\/IGFBPs assessed, IGFBP-2 was the strongest and most consistent predictor of bone turnover in men and women. After adjustment for potential confounders, IGFBP-2 was positively associated with osteocalcin (OC) and urine and serum N-teleopeptide (NTX) in men (r = 0.20, 0.26, and 0.23, respectively; p &amp;lt; 0.001), serum C-telopeptide (CTX) in premenopausal women (r = 0.28; p &amp;lt; 0.01), and OC, urine NTX, and serum CTX in postmenopausal women (r = 0.24, 0.33, and 0.19, respectively; p &amp;lt; 0.05).<\/jats:p>\n               <jats:p>Conclusions: Higher serum IGFBP-2, which is predictive of lower BMD, is associated with increased markers of bone resorption, independent of age, body mass, and sex hormones. The association between IGFBP-2 and markers of bone formation may reflect coupling with increased bone resorption, which is not adequate to maintain BMD.<\/jats:p>","DOI":"10.1359\/jbmr.070306","type":"journal-article","created":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T13:42:39Z","timestamp":1173706959000},"page":"799-807","source":"Crossref","is-referenced-by-count":60,"title":["High Serum IGFBP-2 Is Predictive of Increased Bone Turnover in Aging Men and Women"],"prefix":"10.1093","volume":"22","author":[{"given":"Shreyasee","family":"Amin","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Lawrence","family":"Riggs","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"L Joseph","family":"Melton","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA"},{"name":"Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, 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