{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:41:22Z","timestamp":1789846882562,"version":"4.0.1"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>PTHrP induced a proliferative cyclin D1 activation in low-density osteoblastic cells. The process was PKA and MAPK dependent and involved both AP-1 and CRE sites. In ectopic ossicles generated from implanted bone marrow stromal cells, PTH upregulated cyclin D1 after acute or intermittent anabolic treatment. These data suggest a positive role of PTH and PTHrP in the cell cycle of early osteoblasts.<\/jats:p>\n               <jats:p>Introduction: The mechanisms underlying the actions of PTH and its related protein (PTHrP) in osteoblast proliferation, differentiation, and bone remodeling remain unclear. The action of PTH or PTHrP on the cell cycle during osteoblast proliferation was studied.<\/jats:p>\n               <jats:p>Materials and Methods: Mouse calvarial MC3T3-E1 clone 4 cells were synchronized by serum starvation and induced with 100 nM PTHrP for 2\u201324 h under defined low serum conditions. Western blot, real-time PCR, EMSAs, and promoter\/luciferase assays were performed to evaluate cyclin D1 expression. Pharmacological inhibitors were used to determine the relevant signaling pathways. Ectopic ossicles generated from implanted bone marrow stromal cells were treated with acute (a single 8- or 12-h injection) or intermittent anabolic PTH treatment for 7 days, and RNA and histologic analysis were performed.<\/jats:p>\n               <jats:p>Results: PTHrP upregulated cyclin D1 and CDK1 and decreased p27 expression. Cyclin D1 promoter\/luciferase assays showed that the PTHrP regulation involved both activator protein-1 (AP-1) and cyclic AMP response element binding protein (CRE) sites. AP-1 and CRE double mutants completely abolished the PTHrP effect of cyclin D1 transcription. Upregulation of cyclin D1 was found to be protein kinase A (PKA) and mitogen-activated protein kinase (MAPK) dependent in proliferating MC3T3-E1 cells. In vivo expression of cyclin D1 in ectopic ossicles was upregulated after a single 12-h PTH injection or intermittent anabolic PTH treatment for 7 days in early developing ossicles.<\/jats:p>\n               <jats:p>Conclusions: These data indicate that PTH and PTHrP induce cyclin D1 expression in early osteoblastic cells and their action is developmental stage specific.<\/jats:p>","DOI":"10.1359\/jbmr.070328","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T15:26:52Z","timestamp":1175009212000},"page":"951-964","source":"Crossref","is-referenced-by-count":91,"title":["Cyclin D1 as a Target for the Proliferative Effects of PTH and PTHrP in Early Osteoblastic Cells"],"prefix":"10.1093","volume":"22","author":[{"given":"Nabanita S","family":"Datta","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda J","family":"Pettway","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie K","family":"McCauley","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319292676600_bib1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S8756-3282(01)00433-1","article-title":"Effects of human parathyroid hormone (1-34), LY333334, on bone mass, remodeling, and mechanical properties of cortical bone during the first remodeling cycle in rabbits","volume":"28","author":"Mashiba","year":"2001","journal-title":"Bone"},{"key":"2024020319292676600_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jbmr.5650100203","article-title":"Development and characterization of a conditionally immortalized human fetal osteoblastic cell line","volume":"10","author":"Harris","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1101\/gad.8.3.277","article-title":"Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene","volume":"8","author":"Karaplis","year":"1994","journal-title":"Genes Dev"},{"key":"2024020319292676600_bib4","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1126\/science.273.5275.663","article-title":"PTH\/PTHrP receptor in early development and indian hedgehog-regulated bone growth","volume":"273","author":"Lanske","year":"1996","journal-title":"Science"},{"key":"2024020319292676600_bib5","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1172\/JCI24918","article-title":"Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34","volume":"115","author":"Miao","year":"2005","journal-title":"J Clin Invest"},{"key":"2024020319292676600_bib6","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1359\/jbmr.2000.15.8.1517","article-title":"Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: A comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and SDZ-parathyroid hormone 893","volume":"15","author":"Stewart","year":"2000","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(01)00798-3","article-title":"Parathyroid hormone-dependent signaling pathways regulating genes in bone cells","volume":"282","author":"Swarthout","year":"2002","journal-title":"Gene"},{"key":"2024020319292676600_bib8","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1073\/pnas.89.7.2732","article-title":"Expression cloning of a common receptor for parathryoid hormone and parathryoid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphophates and increases intracellular free calcium","volume":"89","author":"Abou-Samra","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024020319292676600_bib9","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1210\/endo.134.4.8137752","article-title":"Role of protein kinase-A in homologous downregulation of parathyroid hormone (PTH)\/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells","volume":"134","author":"Fukayama","year":"1994","journal-title":"Endocrinology"},{"key":"2024020319292676600_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jbmr.5650100106","article-title":"Expression and secretion of parathyroid hormone-related protein by human bone derived cells in vitro:effects of glucocorticoids","volume":"10","author":"Walsh","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib11","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1210\/endo-118-6-2445","article-title":"Parathyroid hormone stimulated the proliferation of cells derived from human bone","volume":"118","author":"McDonald","year":"1986","journal-title":"Endocrinology"},{"key":"2024020319292676600_bib12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/BF00425877","article-title":"Time-dependent effects of parathyroid hormone and prostaglandin E2 on DNA synthesis by periosteal cells from embryonic chick calvaria","volume":"55","author":"Scutt","year":"1994","journal-title":"Calcif Tissue Int"},{"key":"2024020319292676600_bib13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S8756-3282(00)00264-7","article-title":"Endogeneous parathyroid hormone-related peptide enhances proliferation and inhibits differentiation in the osteoblast-like cell line ROS 17\/2.8","volume":"26","author":"Du","year":"2000","journal-title":"Bone"},{"key":"2024020319292676600_bib14","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1359\/jbmr.1997.12.10.1596","article-title":"The mitogenic effect of parathyroid hormone is associated with E2F-dependent activation of cyclin-dependent kinase 1 (cdc2) in osteoblast precursors","volume":"12","author":"Onishi","year":"1997","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF02557835","article-title":"Inhibitory effects of parathyroid hormone on growth of osteogenic sarcoma cells","volume":"37","author":"Partridge","year":"1985","journal-title":"Calcif Tissue Int"},{"key":"2024020319292676600_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/jbmr.5650080309","article-title":"Cross talk of dual-signal transduction systems in the regulation of DNA synthesis by parathyroid hormone in osteoblastic osteosarcoma cells","volume":"8","author":"Kano","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/joe.0.1670305","article-title":"Estrogen modulates osteoblast proliferation and function regulated by parathyroid hormone in osteoblastic SaOs-2 cells: Role of insulin like growth factor (IGF)-1 and IGF-1 binding protein-5","volume":"167","author":"Nasu","year":"2000","journal-title":"J Endocrinol"},{"key":"2024020319292676600_bib18","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1210\/endo-127-6-3111","article-title":"Parathyroid hormone reversibly suppresses the differentiation of osteoprogenitor cells into functional osteoblasts","volume":"127","author":"Bellows","year":"1990","journal-title":"Endocrinology"},{"key":"2024020319292676600_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/scel.1994.1047","article-title":"Protein kinases and cell cycle control","volume":"5","author":"Pines","year":"1994","journal-title":"Semin Cell Biol"},{"key":"2024020319292676600_bib20","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1359\/JBMR.050106","article-title":"PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest","volume":"20","author":"Datta","year":"2005","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<386::AID-DVG8>3.0.CO;2-2","article-title":"Control of cell cycle gene expression in bone development and during c-Fos-induced osteosarcoma formation","volume":"22","author":"Sunters","year":"1998","journal-title":"Dev Genet"},{"key":"2024020319292676600_bib22","first-page":"5019","article-title":"Expression of cell cycle regulatory factors in differentiating osteoblasts: Postproliferative up-regulation of cyclins B and E","volume":"55","author":"Smith","year":"1995","journal-title":"Cancer Res"},{"key":"2024020319292676600_bib23","doi-asserted-by":"crossref","first-page":"19992","DOI":"10.1074\/jbc.M001758200","article-title":"Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes","volume":"275","author":"Smith","year":"2000","journal-title":"J Biol Chem"},{"key":"2024020319292676600_bib24","first-page":"3705","article-title":"The cell cycle regulator p27kip1 contributes to growth and differentiation of osteoblasts","volume":"59","author":"Drissi","year":"1999","journal-title":"Cancer Res"},{"key":"2024020319292676600_bib25","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1210\/endo.138.5.5146","article-title":"Expression of p27Kip1 in osteoblast-like cells during differentiation with parathyroid hormone","volume":"138","author":"Onishi","year":"1997","journal-title":"Endocrinology"},{"key":"2024020319292676600_bib26","first-page":"61","article-title":"Gene array analysis of osteoblast differentiation","volume":"12","author":"Beck","year":"2001","journal-title":"Cell Growth Differ"},{"key":"2024020319292676600_bib27","doi-asserted-by":"crossref","first-page":"19374","DOI":"10.1074\/jbc.M108913200","article-title":"Parathyroid Hormone and Parathyroid Hormone Related Protein Exert Both Pro- and Anti-apoptotic Effects in Mesenchymal Cells","volume":"277","author":"Chen","year":"2002","journal-title":"J Biol Chem"},{"key":"2024020319292676600_bib28","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/BF02631122","article-title":"Reduction of proliferative heterogeneity of CHEF18 chinese hamster cell line during the progression toward tumorigenicity","volume":"27A","author":"Rainaldi","year":"1991","journal-title":"In Vitro Cell Dev Biol"},{"key":"2024020319292676600_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1091\/mbc.02-06-0101","article-title":"IKK\u00b1 regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf","volume":"14","author":"Albanese","year":"2003","journal-title":"Mol Biol Cell"},{"key":"2024020319292676600_bib30","doi-asserted-by":"crossref","first-page":"29121","DOI":"10.1074\/jbc.M313000200","article-title":"Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts","volume":"279","author":"Chen","year":"2004","journal-title":"J Biol Chem"},{"key":"2024020319292676600_bib31","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0736-0266(03)00042-1","article-title":"Skeletal homeostasis in tissue-engineered bone","volume":"21","author":"Schneider","year":"2003","journal-title":"J Orthop Res"},{"key":"2024020319292676600_bib32","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.bone.2005.02.015","article-title":"Anabolic actions of PTH (1-34): Use of a novel tissue engineering model to investigate temporal effects on bone","volume":"36","author":"Pettway","year":"2005","journal-title":"Bone"},{"key":"2024020319292676600_bib33","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0092-8674(89)90936-7","article-title":"Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2","volume":"58","author":"Pines","year":"1989","journal-title":"Cell"},{"key":"2024020319292676600_bib34","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","article-title":"CDK inhibitors: Positive and negative regulators of G1- phase progression","volume":"13","author":"Sherr","year":"1999","journal-title":"Genes Dev"},{"key":"2024020319292676600_bib35","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0092-8674(94)90257-7","article-title":"Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation","volume":"79","author":"Kato","year":"1994","journal-title":"Cell"},{"key":"2024020319292676600_bib36","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1074\/jbc.M005522200","article-title":"Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells","volume":"276","author":"Nagata","year":"2001","journal-title":"J Biol Chem"},{"key":"2024020319292676600_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1615\/CritRevEukarGeneExpr.v8.i3-4.40","article-title":"Parathyroid hormone-related peptide (PTHrP) and parathyroid hormone(PTH)\/PTHrP receptor","volume":"8","author":"Lanske","year":"1998","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"2024020319292676600_bib38","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tem.2004.01.006","article-title":"Parathyroid hormone: A double-edged sword for bone metabolism","volume":"15","author":"Ling","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"2024020319292676600_bib39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"2024020319292676600_bib40","first-page":"1","volume-title":"Principles of Bone Biology","author":"Aubin","year":"2002","edition":"2nd ed"},{"key":"2024020319292676600_bib41","first-page":"115","article-title":"Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"Manolagas","year":"2000","journal-title":"Endocr Rev"},{"key":"2024020319292676600_bib42","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1210\/me.2001-0103","article-title":"The cyclin D1 and cyclin A genes are targets of activated PTH\/PTHrP receptors in Jansen's metaphyseal chondrodysplasia","volume":"16","author":"Beier","year":"2002","journal-title":"Mol Endocrinol"},{"key":"2024020319292676600_bib43","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/endo-118-2-824","article-title":"Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone","volume":"118","author":"McSheehy","year":"1986","journal-title":"Endocrinology"},{"key":"2024020319292676600_bib44","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2184.2004.00316.x","article-title":"Serial passage of MC3T3-E1 cells down-regulates proliferation during osteogenesis in vitro","volume":"37","author":"Peterson","year":"2004","journal-title":"Cell Prolif"},{"key":"2024020319292676600_bib45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2184.1996.tb00980.x","article-title":"Cell density downregulates DNA synthesis and proliferation during osteogenesis in vitro","volume":"29","author":"Peterson","year":"1996","journal-title":"Cell Prolif"},{"key":"2024020319292676600_bib46","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.yexcr.2005.03.030","article-title":"Control of density-dependent, cell state-specific signal transduction by the cell adhesion molecule CEACAM1, and its influence on cell cycle regulation","volume":"307","author":"Scheffrahn","year":"2005","journal-title":"Exp Cell Res"},{"key":"2024020319292676600_bib47","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/oxfordjournals.jbchem.a134444","article-title":"Density-dependent growth control of adult rat hepatocytes in primary culture","volume":"94","author":"Nakamura","year":"1983","journal-title":"J Biochem (Tokyo)"},{"key":"2024020319292676600_bib48","doi-asserted-by":"crossref","first-page":"7586","DOI":"10.1074\/jbc.M007400200","article-title":"Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent","volume":"276","author":"Swarthout","year":"2001","journal-title":"J Biol Chem"},{"key":"2024020319292676600_bib49","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1210\/endo.140.12.7173","article-title":"Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells","volume":"140","author":"Cole","year":"1999","journal-title":"Endocrinology"},{"key":"2024020319292676600_bib50","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1359\/jbmr.1999.14.6.915","article-title":"Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone- related protein","volume":"14","author":"Cornish","year":"1999","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S8756-3282(96)00350-X","article-title":"Proliferating cells in the primary spongiosa express osteoblastic phenotype in vitro","volume":"20","author":"Onyia","year":"1997","journal-title":"Bone"},{"key":"2024020319292676600_bib52","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1083\/jcb.126.6.1611","article-title":"Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation","volume":"126","author":"Amizuka","year":"1994","journal-title":"J Cell Biol"},{"key":"2024020319292676600_bib53","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.139.2.541","article-title":"Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis","volume":"139","author":"Serra","year":"1997","journal-title":"J Cell Biol"},{"key":"2024020319292676600_bib54","first-page":"5357","article-title":"Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts","volume":"63","author":"Pratap","year":"2003","journal-title":"Cancer Res"},{"key":"2024020319292676600_bib55","doi-asserted-by":"crossref","first-page":"20274","DOI":"10.1074\/jbc.M413665200","article-title":"The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts","volume":"280","author":"Galindo","year":"2005","journal-title":"J Biol Chem"},{"key":"2024020319292676600_bib56","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1210\/endo.142.5.8157","article-title":"Parathyroid hormone stimulates fra-2 expression in osteoblastic cells in vitro and in vivo","volume":"142","author":"McCauley","year":"2001","journal-title":"Endocrinology"},{"key":"2024020319292676600_bib57","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"2024020319292676600_bib58","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1101\/gad.12.22.3499","article-title":"Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization","volume":"12","author":"Diehl","year":"1998","journal-title":"Genes Dev"},{"key":"2024020319292676600_bib59","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/emboj\/19.9.2056","article-title":"Cell cycle-dependent variations in c-Jun and JunB phosphorylation: A role in the control of cyclin D1 expression","volume":"19","author":"Bakiri","year":"2000","journal-title":"EMBO J"},{"key":"2024020319292676600_bib60","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1128\/MCB.18.9.5609","article-title":"Fos family members induce cell cycle entry by activating cyclin D1","volume":"18","author":"Brown","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2024020319292676600_bib61","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1091\/mbc.12.12.3852","article-title":"TGF\u03b2 and PTHrP control chondrocyte proliferation by activating cyclin D1 expression","volume":"12","author":"Beier","year":"2001","journal-title":"Mol Biol Cell"},{"key":"2024020319292676600_bib62","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.96.4.1433","article-title":"Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes","volume":"96","author":"Beier","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024020319292676600_bib63","first-page":"867","article-title":"Parathyroid hormone induction of rat insterstitial collagenase mRNA in osteosarcoma cells is mediated through an AP-1 binding site","volume":"10","author":"Rajakumas","year":"1996","journal-title":"Mol Endocrinol"},{"key":"2024020319292676600_bib64","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1359\/jbmr.2002.17.10.1785","article-title":"Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix","volume":"17","author":"Higuchi","year":"2002","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib65","doi-asserted-by":"crossref","first-page":"36024","DOI":"10.1074\/jbc.M206030200","article-title":"Activations of ERK1\/2 and JNK by transforming growth factor \u03b2 negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells","volume":"277","author":"Sowa","year":"2002","journal-title":"J Biol Chem"},{"key":"2024020319292676600_bib66","first-page":"S114","article-title":"Anabolic actions of PTH in bone: Role of osteoblast proliferation, differentiation, and combinatorial treatment with bisphosphonates","volume":"21","author":"Pettway","year":"2006","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib67","first-page":"S321","article-title":"Behavior of preosteoblastic cells following intermittent PTH treatment","volume":"21","author":"Freitas","year":"2006","journal-title":"J Bone Miner Res"},{"key":"2024020319292676600_bib68","first-page":"351","volume-title":"Bone: The Osteoblast and Osteocyte","author":"Parfitt","year":"1990"},{"key":"2024020319292676600_bib69","doi-asserted-by":"crossref","first-page":"16347","DOI":"10.1074\/jbc.M603439200","article-title":"Cyclin D1-Cdk4 induce Runx2 ubiquitination and degradation","volume":"281","author":"Shen","year":"2006","journal-title":"J Biol Chem"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1359%2Fjbmr.070328","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/22\/7\/951\/56552788\/5650220701.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/22\/7\/951\/56552788\/5650220701.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:48:49Z","timestamp":1710341329000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/22\/7\/951-964\/7597380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,1]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2009,12,4]]},"published-print":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1359\/jbmr.070328","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,7,1]]},"published":{"date-parts":[[2007,7,1]]}}}