{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:32:01Z","timestamp":1787614321807,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study investigates the impact of \u03b1-CGRP on bone metabolism after implantation of polyethylene particles. \u03b1-CGRP knockout mice showed less osteolysis compared with wildtype mice. The local neurogenic microenvironment might be a crucial factor in particle-induced osteolysis.<\/jats:p>\n               <jats:p>Introduction: Periprosthetic osteolysis is the major reason for aseptic loosening in joint arthroplasty. This study aimed to investigate the potential impact of \u03b1-calcitonin gene\u2013related peptide (\u03b1-CGRP) deficiency on bone metabolism under conditions of polyethylene particle\u2013induced osteolysis.<\/jats:p>\n               <jats:p>Materials and Methods: We used the murine calvarial osteolysis model based on polyethylene particles in 14 C57BL 6 mice and 14 \u03b1-CGRP\u2013deficient mice divided into four groups of 7 mice each. Groups 1 (C57BL\/J 6) and 3 (\u03b1-CGRP knockout) received sham surgery, and groups 2 (C57BL\/J 6) and 4 (\u03b1-CGRP knockout) were treated with polyethylene particles. Qualitative and quantitative 3D analyses were performed using \u03bcCT. In addition, bone resorption was measured within the midline suture by histological examination. The number of osteoclasts was determined by counting the TRACP+ cells. Calvarial bone was tested for RANKL expression by RT-PCR and immunocytochemistry.<\/jats:p>\n               <jats:p>Results: Bone resorption was significantly reduced in \u03b1-CGRP\u2013deficient mice compared with their corresponding wildtype C57BL 6 mice as confirmed by histomorphometric data (p &amp;lt; 0.001) and \u03bcCT (p &amp;lt; 0.01). Osteoclast numbers were significantly reduced in group 3 and the particle subgroup compared with group 1 (p &amp;lt; 0.001). We observed a &amp;gt;3-fold increase of basal RANKL mRNA levels within group 1 compared with group 3. Additional low RANKL immunochemistry staining was noted in groups 3 and 4.<\/jats:p>\n               <jats:p>Conclusions: In conclusion, \u03b1-CGRP knockout mice did not show the expected extended osteolysis compared with wildtype mice expressing \u03b1-CGRP. One of the most reasonable explanations for the observed decrease in osteolysis could be linked to the osteoprotegerin (OPG)\/RANK\/RANKL system in \u03b1-CGRP\u2013deficient animals. As a consequence, the fine tuning of osteoclasts mediating resorption in \u03b1-CGRP\u2013null mice may be deregulated.<\/jats:p>","DOI":"10.1359\/jbmr.070408","type":"journal-article","created":{"date-parts":[[2007,4,9]],"date-time":"2007-04-09T18:53:03Z","timestamp":1176144783000},"page":"1011-1019","source":"Crossref","is-referenced-by-count":26,"title":["Polyethylene Particle\u2013Induced Bone Resorption in \u03b1-Calcitonin Gene\u2013Related Peptide\u2013Deficient Mice"],"prefix":"10.1093","volume":"22","author":[{"given":"Christian","family":"Wedemeyer","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Neuerburg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Heckelei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bylski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"von Knoch","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Schulthess Clinic, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Schinke","sequence":"additional","affiliation":[{"name":"Center for Biomechanics and Skeletal Biology, Department of Trauma Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gero","family":"Hilken","sequence":"additional","affiliation":[{"name":"Central Animal Laboratory, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Gosheger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"von Knoch","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"L\u00f6er","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Saxler","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of Duisburg-Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319285977200_bib1","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.2106\/00004623-200208000-00038","article-title":"What's new in orthopaedic research","volume":"84","author":"Silva","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"2024020319285977200_bib2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00003086-199009000-00013","article-title":"Osteolysis in alloarthroplasty of the hip. 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