{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:27:28Z","timestamp":1773293248576,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We performed a longitudinal analysis of bone quality in Sca-1\u2013null mice. A tight temporal, site-specific association between Sca-1\u2013deficient BMD deficiency and reduced mesenchymal progenitor frequency was observed. Defects in trabecular microarchitecture and mineralization were, at least partially, responsible for the age-related reduction in toughness of Sca-1\u2212\/\u2212 bones.<\/jats:p>\n               <jats:p>Introduction: We previously showed that stem cell antigen 1 (Sca-1)\u2013null mice undergo normal bone development but exhibit significantly decreased bone mass characteristic of age-dependent osteoporosis. The objective of this study was to characterize the initiation and progression of the Sca-1 mutant skeletal phenotype at the cellular, structural, material, and mechanical levels.<\/jats:p>\n               <jats:p>Materials and Methods: Sca-1\u2013null and control mice were analyzed at 3, 5, 7, and 9 mo of age. In vitro osteoclastogenesis of bone marrow and spleen-derived progenitor populations was assessed. Bone marrow\u2013derived mesenchymal progenitor frequency, along with osteogenic and adipogenic differentiation potential, was analyzed in vitro. Static histomorphometry of the sixth lumbar vertebrae was performed. Whole body, femoral, and vertebral BMD were assessed using DXA. Lumbar vertebrae were analyzed using \u03bcCT, back-scattered electron imaging, and compression tests. Three-point bending and femoral neck fracture tests were performed on excised femurs.<\/jats:p>\n               <jats:p>Results: Sca-1\u2013null mice displayed an age-dependent, cell-autonomous osteoclast deficiency in vitro. From 7 mo of age onward, reduced Sca-1\u2013null femoral BMD was observed alongside reduced mesenchymal progenitor frequency, and decreased in vitro osteogenic and adipogenic differentiation potential. Sca-1\u2013deficient mice exhibited reduced whole body BMD compared with controls at all time-points analyzed. Although no differences in spinal BMD were observed, Sca-1\u2212\/\u2212 vertebrae exhibited decreased bone formation, with a maximal difference at 7 mo of age, inferior trabecular microarchitecture, and a greater degree of mineralization. At all sites tested, Sca-1\u2013null bones exhibited reduced energy to failure from 5 mo onward.<\/jats:p>\n               <jats:p>Conclusions: We showed a tight association within Sca-1\u2013null mice between the initiation of stem cell defects and the exacerbation of deficiencies in bone quality at two sites clinically relevant to developing osteoporotic fractures. Sca-1\u2013deficient mice, therefore, provide a novel and useful murine model of age-related osteoporosis, which with additional study, should further our understanding of the mechanisms underlying this increasingly prevalent disease.<\/jats:p>","DOI":"10.1359\/jbmr.070604","type":"journal-article","created":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T20:04:40Z","timestamp":1180987480000},"page":"1373-1386","source":"Crossref","is-referenced-by-count":30,"title":["Longitudinal Analysis of Mesenchymal Progenitors and Bone Quality in the Stem Cell Antigen-1\u2013Null Osteoporotic Mouse"],"prefix":"10.1093","volume":"22","author":[{"given":"Christina","family":"Holmes","sequence":"first","affiliation":[{"name":"Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayyab S","family":"Khan","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute, Mount 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