{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:26:38Z","timestamp":1791026798162,"version":"4.1.0"},"reference-count":188,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It was previously believed that obesity and osteoporosis were two unrelated diseases, but recent studies have shown that both diseases share several common genetic and environmental factors. Body fat mass, a component of body weight, is one of the most important indices of obesity, and a substantial body of evidence indicates that fat mass may have beneficial effects on bone. Contrasting studies, however, suggest that excessive fat mass may not protect against osteoporosis or osteoporotic fracture. Differences in experimental design, sample structure, and even the selection of covariates may account for some of these inconsistent or contradictory results. Despite the lack of a clear consensus regarding the impact of effects of fat on bone, a number of mechanistic explanations have been proposed to support the observed epidemiologic and physiologic associations between fat and bone. The common precursor stem cell that leads to the differentiation of both adipocytes and osteoblasts, as well the secretion of adipocyte-derived hormones that affect bone development, may partially explain these associations. Based on our current state of knowledge, it is unclear whether fat has beneficial effects on bone. We anticipate that this will be an active and fruitful focus of research in the coming years.<\/jats:p>","DOI":"10.1359\/jbmr.070813","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T10:16:49Z","timestamp":1188901009000},"page":"17-29","source":"Crossref","is-referenced-by-count":427,"title":["Correlation of Obesity and Osteoporosis: Effect of Fat Mass on the Determination of Osteoporosis"],"prefix":"10.1093","volume":"23","author":[{"given":"Lan-Juan","family":"Zhao","sequence":"first","affiliation":[{"name":"These authors contributed equally to this paper"},{"name":"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Statistical Genetics, College of Life Science, Hunan Normal University, Changsha, Hunan, China"},{"name":"These authors contributed equally to this paper"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Papasian","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dev","family":"Maulik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Missouri-Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Drees","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Wen","family":"Deng","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China"},{"name":"Laboratory of Molecular and Statistical Genetics, College of Life Science, Hunan Normal University, Changsha, Hunan, China"},{"name":"Departments of Orthopedic Surgery and Basic Medical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319444822500_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1098-3597(99)90002-9","article-title":"Obesity and its comorbid conditions","volume":"2","author":"Khaodhiar","year":"1999","journal-title":"Clin Cornerstone"},{"key":"2024020319444822500_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/jama.1994.03520030047027","article-title":"Increasing prevalence of overweight among US adults. 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