{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:18:35Z","timestamp":1781849915147,"version":"3.54.5"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nontumoral notochordal inclusions in vertebral bone marrow give rise to MRI-detectable lesion without osteolysis, and their detection may cause concern or overtreatment. These lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment.<\/jats:p>\n               <jats:p>We present a case of nontumoral notochordal inclusions in vertebral bone marrow, giving rise to an MRI detectable lesion without osteolysis. MRI detection of such lesions may cause concern or overtreatment. Quite distinct from chordomas, these lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment.<\/jats:p>","DOI":"10.1359\/jbmr.071204","type":"journal-article","created":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T13:13:13Z","timestamp":1197378793000},"page":"572-575","source":"Crossref","is-referenced-by-count":9,"title":["Notochordal Inclusions in the Vertebral Bone Marrow"],"prefix":"10.1093","volume":"23","author":[{"given":"Alessandro","family":"Corsi","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Sperimentale, Universit\u00e0 \u201cLa Sapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"De Maio","sequence":"additional","affiliation":[{"name":"Dipartimento di Chirurgia Ortopedica, Universit\u00e0 di Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Mancini","sequence":"additional","affiliation":[{"name":"Dipartimento di Chirurgia Ortopedica, Universit\u00e0 di Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Ippolito","sequence":"additional","affiliation":[{"name":"Dipartimento di Chirurgia Ortopedica, Universit\u00e0 di Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Riminucci","sequence":"additional","affiliation":[{"name":"Parco Scientifico Biomedico San Raffaele, Rome, Italy"},{"name":"Dipartimento di Medicina Sperimentale, Universit\u00e0 dell'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bianco","sequence":"additional","affiliation":[{"name":"Parco Scientifico Biomedico San Raffaele, Rome, Italy"},{"name":"Dipartimento di Medicina Sperimentale, Universit\u00e0 \u201cLa Sapienza\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319544092700_bib1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00000478-200303000-00015","article-title":"Giant vertebral notochordal rest: A lesion distinct from chordoma: Discussion of an evolving concept","volume":"27","author":"Kyriakos","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"2024020319544092700_bib2","volume-title":"The Borderland of Embryology and Pathology","author":"Willis","year":"1962"},{"key":"2024020319544092700_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00003086-198203000-00042","article-title":"Ecchordosis physaliphora vertebralis","volume":"163","author":"Ulich","year":"1982","journal-title":"Clin Orthop Relat Res"},{"key":"2024020319544092700_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/path.1711710404","article-title":"The pathology of the human notochord","volume":"171","author":"Salisbury","year":"1993","journal-title":"J Pathol"},{"key":"2024020319544092700_bib5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2559.2004.01877.x","article-title":"Intraosseous benign notochordal cell tumours: Overlooked precursors of classic chordomas?","volume":"44","author":"Yamaguchi","year":"2004","journal-title":"Histopathology"},{"key":"2024020319544092700_bib6","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s002560050528","article-title":"Vertebral intra-osseous chordoma or giant notochordal rest?","volume":"28","author":"Darby","year":"1999","journal-title":"Skeletal Radiol"},{"key":"2024020319544092700_bib7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1365-2559.2005.02168.x","article-title":"Giant vertebral notochordal rest: A new entity distinct from chordoma","volume":"47","author":"Chauvel","year":"2005","journal-title":"Histopathology"},{"key":"2024020319544092700_bib8","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s002560100422","article-title":"Giant notochordal hamartoma of intraosseous origin: A newly reported benign entity to be distinguished from chordoma. 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