{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:14:28Z","timestamp":1772169268913,"version":"3.50.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vitamin D insufficiency (VDI) is widely reported. In patients with normal PTH, the diagnosis rests on increases in fractional calcium absorption (FCA) when 25(OH)D increases above 30 ng\/ml. However, estimates of increased FCA after correction of VDI vary dramatically, depending on study methods. We used a dual stable calcium isotope to clarify the impact of vitamin D repletion on FCA in postmenopausal women with VDI. We hypothesized that FCA would increase with vitamin D repletion. We studied postmenopausal women with VDI [25(OH)D = 16\u201324 ng\/ml] and an estimated calcium intake \u22641100 mg daily. Exclusion criteria included hypercalcemia, hypercalciuria, renal insufficiency, nephrolithiasis, gastrointestinal disorders, osteomalacia, prior adult fragility fracture, baseline T-score &amp;lt; \u22123.0, and use of medications known to interfere with vitamin D or calcium metabolism. Each woman underwent inpatient FCA studies before and after correction of VDI. We used ergocalciferol 50,000 IU\/d for 15 days to achieve vitamin D repletion. During each study, women consumed their typical diet. They ingested 44Ca orally with breakfast and received 42Ca intravenously. We collected urine for 24 h and measured its calcium isotope content by mass spectrometry. Eighteen women completed the study; all but two had normal PTH. During the first and second FCA studies, their mean 25(OH)D level was 22 \u00b1 4 and 64 \u00b1 21 ng\/ml, respectively (p &amp;lt; 0.001). Subjects' average FCA was 24 \u00b1 7% initially and 27 \u00b1 6% after vitamin D repletion (p = 0.04). Thus, FCA increased by 3 \u00b1 1% with correction of VDI. Postmenopausal women with VDI experience small FCA increments with vitamin D therapy. In existing literature, this small change in FCA does not associate with lower fracture rates or consistently higher bone mass. Future studies should ascertain whether small FCA increments favorably affect the skeleton.<\/jats:p>","DOI":"10.1359\/jbmr.080230","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T09:05:02Z","timestamp":1204016702000},"page":"1052-1060","source":"Crossref","is-referenced-by-count":92,"title":["Vitamin D Insufficiency: Disease or No Disease?"],"prefix":"10.1093","volume":"23","author":[{"given":"Karen E","family":"Hansen","sequence":"first","affiliation":[{"name":"University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, Wisconsin, USA"},{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea N","family":"Jones","sequence":"additional","affiliation":[{"name":"University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, Wisconsin, USA"},{"name":"University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J","family":"Lindstrom","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Wisconsin General Clinical Research Center, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean A","family":"Engelke","sequence":"additional","affiliation":[{"name":"University of Wisconsin Osteoporosis Clinical Center and Research Program, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin M","family":"Shafer","sequence":"additional","affiliation":[{"name":"Wisconsin State Laboratory of Hygiene, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319513385500_bib1","first-page":"569","volume-title":"Vitamin D","author":"Peacock","year":"1985"},{"key":"2024020319513385500_bib2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/07315724.2003.10719287","article-title":"Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D","volume":"22","author":"Heaney","year":"2003","journal-title":"J Am Coll Nutr"},{"key":"2024020319513385500_bib3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJM199803193381201","article-title":"Hypovitaminosis D in medical inpatients","volume":"338","author":"Thomas","year":"1998","journal-title":"N Engl J Med"},{"key":"2024020319513385500_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1046\/j.1365-2265.1999.00764.x","article-title":"Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis","volume":"51","author":"Sahota","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2024020319513385500_bib5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s001980050030","article-title":"Prevalence of vitamin D insufficiency in an adult normal population","volume":"7","author":"Chapuy","year":"1997","journal-title":"Osteoporos Int"},{"key":"2024020319513385500_bib6","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1210\/jcem.86.3.7327","article-title":"A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: Baseline data from the multiple outcomes of raloxifene evaluation clinical trial","volume":"86","author":"Lips","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2024020319513385500_bib7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00198-005-1867-7","article-title":"Estimates of optimal vitamin D status","volume":"16","author":"Dawson-Hughes","year":"2005","journal-title":"Osteoporos Int"},{"key":"2024020319513385500_bib8","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1210\/jc.2003-031979","article-title":"Assay variation confounds the diagnosis of hypovitaminosis D: A call for standardization","volume":"89","author":"Binkley","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2024020319513385500_bib9","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/archinte.1983.00350060124020","article-title":"Nutrition and the health of the elderly. 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