{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:40:58Z","timestamp":1787067658996,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypoparathyroidism, a disorder in which PTH is absent, is associated with BMD that is above average. We studied associated structural and dynamic properties of the skeleton in hypoparathyroidism. Thirty-three subjects with hypoparathyroidism and 33 age- and sex-matched control subjects with no known metabolic diseases underwent percutaneous iliac crest bone biopsies after double-labeling with tetracycline. The main outcome was histomorphometric assessment of structural and dynamic skeletal parameters. Subjects with hypoparathyroidism had greater cancellous bone volume (mean \u00b1 SD; BV\/TV: 23.5 \u00b1 8 versus 19.7 \u00b1 5%, p = 0.02), trabecular width (Tb.Wi: 136.1 \u00b1 37 versus 119.3 \u00b1 21 \u03bcm, p = 0.03), and cortical width (Ct.Wi: 923.4 \u00b1 420 versus 753.5 \u00b1 246 \u03bcm, p = 0.05) than control subjects. Dynamic skeletal indices, including mineralizing surface (MS: 0.85 \u00b1 1.58 versus 4.27 \u00b1 3.32%, p &amp;lt; 0.0001) and bone formation rate (BFR\/BS: 0.006 \u00b1 0.014 versus 0.032 \u00b1 0.028 \u03bcm3\/\u03bcm2\/d, p &amp;lt; 0.0001), were profoundly suppressed in the hypoparathyroid subjects. We conclude that hypoparathyroidism is characterized by markedly unusual structural and dynamic properties of bone.<\/jats:p>","DOI":"10.1359\/jbmr.080803","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T10:55:15Z","timestamp":1218020115000},"page":"2018-2024","source":"Crossref","is-referenced-by-count":192,"title":["Dynamic and Structural Properties of the Skeleton in Hypoparathyroidism"],"prefix":"10.1093","volume":"23","author":[{"given":"Mishaela R","family":"Rubin","sequence":"first","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Dempster","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shane","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Nickolas","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"James","family":"Sliney","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonni J","family":"Silverberg","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Bilezikian","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, Columbia University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319465919300_bib1","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1210\/jc.2004-0021","article-title":"Calcium-sensing receptor autoantibodies are relevant markers of acquired hypoparathyroidism","volume":"89","author":"Mayer","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2024020319465919300_bib2","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1056\/NEJM199006283222601","article-title":"Clinical variation of autoimmune 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