{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T22:09:05Z","timestamp":1717366145123},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Absolute 10-yr fracture risk based on multiple factors is the preferred method for risk assessment. A simplified risk assessment system from sex, age, DXA, and two clinical risk factors (CRFs)\u2014prior fracture and systemic corticosteroid (CS) use-has been used in Canada since 2005. This study was undertaken to evaluate this system in the Canadian female population. A total of 16,205 women \u226550 yr of age at the time of baseline BMD (1998\u20132002) were identified in a database containing all clinical DXA test results for the Province of Manitoba, Canada. Basal 10-yr fracture risk from age and minimum T-score (lumbar spine, femur neck, trochanter, total hip) was categorized as low (&amp;lt;10%), moderate (10\u201320%), or high (&amp;gt;20%). Health service records since 1987 were assessed for prior fracture codes (N = 5224), recent major CS use (N = 616), and fracture codes after BMD testing (mean, 3.1 yr of follow-up) for the hip, vertebrae, forearm, or humerus (designated osteoporotic, N = 757). Fracture risk predicted from age and minimum T-score alone showed a significant gradient in observed fracture rates (low 5.1 [95% CI, 4.1\u20136.4], moderate 11.5 [95% CI, 10.1\u201313.0], high 25.4 [95% CI, 23.2\u201327.9] per 1000 person-years; p-for-trend &amp;lt;0.0001). There was an incremental increase in incident fracture rates from a prior fracture (13.9 [95% CI, 11.3\u201316.4] per 1000 person-years) or major CS use (11.2 [95% CI, 4.1\u201318.2] per 1000 person-years). This simplified fracture risk assessment system provides an assessment of fracture risk that is consistent with observed fracture rates.<\/jats:p>","DOI":"10.1359\/jbmr.081012","type":"journal-article","created":{"date-parts":[[2008,10,10]],"date-time":"2008-10-10T14:51:55Z","timestamp":1223650315000},"page":"353-360","source":"Crossref","is-referenced-by-count":27,"title":["Simplified System for Absolute Fracture Risk Assessment: Clinical Validation in Canadian Women"],"prefix":"10.1093","volume":"24","author":[{"given":"William D","family":"Leslie","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Manitoba, Winnipeg, Canada"},{"name":"Department of Medicine, University of Manitoba, Winnipeg, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Manitoba, Winnipeg, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M","family":"Lix","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Saskatchewan, Saskatoon, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020320051968200_bib1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s001980070050","article-title":"Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: The Canadian Multicentre Osteoporosis Study (CaMos)","volume":"11","author":"Tenenhouse","year":"2000","journal-title":"Osteoporos Int"},{"key":"2024020320051968200_bib2","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","article-title":"An estimate of the worldwide prevalence and disability associated with osteoporotic fractures","volume":"17","author":"Johnell","year":"2006","journal-title":"Osteoporos Int"},{"key":"2024020320051968200_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0889-8529(02)00061-0","article-title":"Epidemiology worldwide","volume":"32","author":"Melton","year":"2003","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2024020320051968200_bib4","first-page":"1357","article-title":"Current and projected rates of hip fracture in Canada","volume":"157","author":"Papadimitropoulos","year":"1997","journal-title":"CMAJ"},{"key":"2024020320051968200_bib5","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1001\/archinte.1996.00440130053006","article-title":"Mortality following fractures in older women. 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