{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:16:02Z","timestamp":1792818962371,"version":"4.5.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Identification of those at high risk of osteoporosis and fractures using clinically available tests beyond BMD measures is a major clinical challenge. We examined forced expiratory volume in 1 s (FEV1), an easily obtainable measure of respiratory function, as a clinical measure for fracture prediction. In the context of the European Prospective Investigation into Cancer-Norfolk Study, 8304 women and 6496 men 42\u201381 yr of age underwent a health check including spirometry and heel quantitative ultrasonography between 1997 and 2000 and were followed up for incident hip fractures until 2007. The main outcome measures were broadband ultrasound attenuation (BUA) of the heel (cross-sectional analysis) and hip fracture risk (prospective analysis). In multivariate regression models, a 1-liter increase in FEV1 was associated with a statistically significant 2.2-dB\/MHz increase in BUA, independent of age, smoking, height, body mass index, history of fracture, and use of corticosteroids. Mean FEV1 was significantly lower among 84 women and 36 men with hip fracture compared with other participants. In multivariate proportional-hazard regression models, the relative risk (RR) of hip fracture associated with a 1-liter increase in FEV1 was 0.5 (95% CI, 0.3\u20130.9; p &amp;lt; 0.001) for both men and women. RR of hip fracture for a 1 SD increase in FEV1 was approximately equivalent to a 0.5 SD increase in BUA among women (1 SD among men) and an \u223c5-yr decrease in age among both men and women. Middle-aged and older people with low respiratory function are at increased risk of osteoporosis and hip fracture. FEV1, an easy, low-cost, and feasible clinical measure, may help improve the identification of high-risk groups.<\/jats:p>","DOI":"10.1359\/jbmr.081231","type":"journal-article","created":{"date-parts":[[2008,12,8]],"date-time":"2008-12-08T22:07:12Z","timestamp":1228774032000},"page":"956-963","source":"Crossref","is-referenced-by-count":9,"title":["Respiratory Function as a Marker of Bone Health and Fracture Risk in an Older Population"],"prefix":"10.1093","volume":"24","author":[{"given":"Alireza","family":"Moayyeri","sequence":"first","affiliation":[{"name":"Department of Public Health and Primary Care, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila A","family":"Bingham","sequence":"additional","affiliation":[{"name":"Medical Research Council, Dunn Human Nutrition Unit, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N","family":"Luben","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Wareham","sequence":"additional","affiliation":[{"name":"Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay-Tee","family":"Khaw","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020320011769700_bib1","first-page":"163","author":"Cummings","year":"1990"},{"key":"2024020320011769700_bib2","first-page":"646","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull World Health Organ"},{"key":"2024020320011769700_bib3","author":"Kanis","year":"2007"},{"key":"2024020320011769700_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01623184","article-title":"Hip fractures in the elderly: A world-wide projection","volume":"2","author":"Cooper","year":"1992","journal-title":"Osteoporos Int"},{"key":"2024020320011769700_bib5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00198-007-0349-5","article-title":"Cost-effectiveness of alendronate in the treatment of postmenopausal women in 9 European countries - an economic evaluation based on the fracture intervention trial","volume":"18","author":"Strom","year":"2007","journal-title":"Osteoporos Int"},{"key":"2024020320011769700_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.maturitas.2003.12.013","article-title":"Association between respiratory function and osteoporosis in pre- and postmenopausal women","volume":"48","author":"Choi","year":"2004","journal-title":"Maturitas"},{"key":"2024020320011769700_bib7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s001980200097","article-title":"An association between respiratory function and bone mineral density in women from the general community: A cross sectional study","volume":"13","author":"Lekamwasam","year":"2002","journal-title":"Osteoporos Int"},{"key":"2024020320011769700_bib8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00198-004-1673-7","article-title":"An association between respiratory function and hip bone mineral density in older men: A cross-sectional study","volume":"16","author":"Lekamwasam","year":"2005","journal-title":"Osteoporos Int"},{"key":"2024020320011769700_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7326\/0003-4819-129-2-199807150-00002","article-title":"Physical activity and osteoporotic fracture risk in older women. 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