{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:18:24Z","timestamp":1784308704809,"version":"3.55.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A higher calcium intake is still the primary recommendation for the prevention of osteoporosis, whereas vitamin D deficiency is often not addressed. To study the relative importance of dietary calcium intake and serum 25-hydroxyvitamin D [25(OH)D] status in regard to hip BMD, 4958 community-dwelling women and 5003 men \u226520 yr of age from the U.S. NHANES III population-based survey were studied. Calcium supplement users and individuals with a prior radius or hip fracture were excluded. We calculated standardized means for BMD by quartiles of sex-specific calcium intake for three 25(OH)D categories (&amp;lt;50, 50\u201374, and 75+ nM) among men and women, separately controlling for other important predictors of BMD. A higher calcium intake was significantly associated with higher BMD (p value for trend: p = 0.005) only for women with 25(OH)D status &amp;lt;50 nM, whereas calcium intake beyond the upper end of the lowest quartile (&amp;gt;566 mg\/d) was not significantly associated with BMD at 25(OH)D concentrations &amp;gt;50 nM. Among men, there was no significant association between a higher calcium intake beyond the upper end of the lowest quartile (626 mg\/d) and BMD within all 25(OH)D categories. Among both sexes, BMD increased stepwise and significantly with higher 25(OH)D concentrations (&amp;lt;50, 50\u201374, 75+ nM; p value for trend: women &amp;lt; 0.0001; men = 0.0001). Among men and women, 25(OH)D status seems to be the dominant predictor of BMD relative to calcium intake. Only women with 25(OH)D concentrations &amp;lt;50 nM seem to benefit from a higher calcium intake.<\/jats:p>","DOI":"10.1359\/jbmr.081242","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:01:01Z","timestamp":1230580861000},"page":"935-942","source":"Crossref","is-referenced-by-count":190,"title":["Dietary Calcium and Serum 25-Hydroxyvitamin D Status in Relation to BMD Among U.S. Adults"],"prefix":"10.1093","volume":"24","author":[{"given":"Heike A","family":"Bischoff-Ferrari","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Institute for Physical Medicine and Rehabilitation, University Hospital Zurich, Zurich, Switzerland"},{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA"},{"name":"Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P","family":"Kiel","sequence":"additional","affiliation":[{"name":"Institute for Aging Research, Hebrew Senior Life, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bess","family":"Dawson-Hughes","sequence":"additional","affiliation":[{"name":"Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"Orav","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA"},{"name":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Spiegelman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA"},{"name":"Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, The School of Dentistry, University of Birmingham, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter C","family":"Willett","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020320020190500_bib1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.2105\/AJPH.87.6.992","article-title":"Milk, dietary calcium, and bone fractures in women: A 12-year prospective study","volume":"87","author":"Feskanich","year":"1997","journal-title":"Am J Public Health"},{"key":"2024020320020190500_bib2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/07315724.2003.10719287","article-title":"Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D","volume":"22","author":"Heaney","year":"2003","journal-title":"J Am Coll Nutr"},{"key":"2024020320020190500_bib3","first-page":"4111","article-title":"Calcium absorptive effects of vitamin D and its major metabolites","volume":"82","author":"Heaney","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2024020320020190500_bib4","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1001\/jama.294.18.2336","article-title":"Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake","volume":"294","author":"Steingrimsdottir","year":"2005","journal-title":"JAMA"},{"key":"2024020320020190500_bib5","first-page":"3908","article-title":"Early identification of children predisposed to low peak bone mass and osteoporosis later in life","volume":"85","author":"Loro","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2024020320020190500_bib6","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM199503233321202","article-title":"Risk factors for hip fracture in white women. 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