{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:23:49Z","timestamp":1792437829158,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The \u201cJ shape\u201d curve linking the risk of poor bone health to alcohol intake is now well recognized from epidemiological studies. Ethanol and nonethanol components of alcoholic beverages could influence bone remodeling. However, in the absence of a solid underlying mechanism, the positive association between moderate alcoholic intake and BMD remains questionable because of confounding associated social factors. The objective of this work was to characterize the short-term effects of moderate alcohol consumption on circulating bone markers, especially those involved in bone resorption. Two sequential blood-sampling studies were undertaken in fasted healthy volunteers (age, 20\u201347 yr) over a 6-h period using beer of different alcohol levels (&amp;lt;0.05\u20134.6%), solutions of ethanol or orthosilicic acid (two major components of beer), and water \u00b1 calcium chloride (positive and negative controls, respectively). Study 1 (24 subjects) assessed the effects of the different solutions, whereas study 2 (26 subjects) focused on ethanol\/beer dose. Using all data in a \u201cmixed effect model,\u201d we identified the contributions of the individual components of beer, namely ethanol, energy, low-dose calcium, and high-dose orthosilicic acid, on acute bone resorption. Markers of bone formation were unchanged throughout the study for all solutions investigated. In contrast, the bone resorption marker, serum carboxy terminal telopeptide of type I collagen (CTX), was significantly reduced after ingestion of a 0.6 liters of ethanol solution (&amp;gt;2% ethanol; p \u2264 0.01, RM-ANOVA), 0.6 liters of beer (&amp;lt;0.05\u20134.6% ethanol; p &amp;lt; 0.02), or a solution of calcium (180 mg calcium; p &amp;lt; 0.001), but only after calcium ingestion was the reduction in CTX preceded by a significant fall in serum PTH (p &amp;lt; 0.001). Orthosilicic acid had no acute effect. Similar reductions in CTX, from baseline, were measured in urine after ingestion of the test solutions; however, the biological variability in urine CTX was greater compared with serum CTX. Modeling indicated that the major, acute suppressive effects of moderate beer ingestion (0.6 liters) on CTX were caused by energy intake in the early phase (\u223c0\u20133 h) and a \u201cnonenergy\u201d ethanol component in the later phase (\u223c3 to &amp;gt;6 h). The early effect on bone resorption is well described after the intake of energy, mediated by glucagon-like peptide-2, but the late effect of moderate alcohol ingestion is novel, seems to be ethanol specific, and is mediated in a non\u2013calcitonin- and a non\u2013PTH-dependent fashion, thus providing a mechanism for the positive association between moderate alcohol ingestion and BMD.<\/jats:p>","DOI":"10.1359\/jbmr.090222","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T19:57:25Z","timestamp":1236110245000},"page":"1380-1388","source":"Crossref","is-referenced-by-count":46,"title":["Moderate Ingestion of Alcohol Is Associated With Acute Ethanol-Induced Suppression of Circulating CTX in a PTH-Independent Fashion"],"prefix":"10.1093","volume":"24","author":[{"given":"Supannee","family":"Sripanyakorn","sequence":"first","affiliation":[{"name":"Faculty of Science and Technology, Loei Rajabhat University, Loei-Chiangkan Road, A. Muang, Loei, Thailand"},{"name":"Gastrointestinal Laboratory, The Rayne Institute (King's College London), St. Thomas' Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravin","family":"Jugdaohsingh","sequence":"additional","affiliation":[{"name":"MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, United Kingdom"},{"name":"Gastrointestinal Laboratory, The Rayne Institute (King's College London), St. Thomas' Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Mander","sequence":"additional","affiliation":[{"name":"MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Davidson","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, The Rayne Institute (King's College London), St. Thomas' Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard PH","family":"Thompson","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, The Rayne Institute (King's College London), St. Thomas' Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J","family":"Powell","sequence":"additional","affiliation":[{"name":"MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319584859500_bib1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0002-9610(00)00486-4","article-title":"Alcohol, wine, and health","volume":"180","author":"De Loromier","year":"2000","journal-title":"Am J 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