{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:12:07Z","timestamp":1787235127885,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary hyperparathyroidism (PHPT) is a common endocrine disease that is associated with multiple endocrine neoplasia type 1 (MEN1) in \u223c2% of PHPT cases. Lack of a family history and other specific expressions may lead to underestimated MEN1 prevalence in PHPT. The aim of this study was to identify clinical or biochemical features predictive of MEN1 and to compare the severity of the disease in MEN1-related versus sporadic PHPT (sPHPT). We performed a 36-mo cross-sectional observational study in three tertiary referral centers on an outpatient basis on 469 consecutive patients with sporadic PHPT and 64 with MEN1-related PHPT. Serum calcium, phosphate, PTH, 25(OH)D3, and creatinine clearance were measured, and ultrasound examination of the urinary tract\/urography was performed in all patients. In 432 patients, BMD was measured at the lumbar spine (LS) and femoral neck (FN). MEN1 patients showed lower BMD Z-scores at the LS (\u22121.33 \u00b1 1.23 versus \u22120.74 \u00b1 1.4, p = 0.008) and FN (\u22121.13 \u00b1 0.96 versus \u22120.6 \u00b1 1.07, p = 0.002) and lower phosphate (2.38 \u00b1 0.52 versus 2.56 \u00b1 0.45 mg\/dl, p = 0.003) and PTH (113.8 \u00b1 69.5 versus 173.7 \u00b1 135 pg\/ml, p = 0.001) levels than sPHPT patients. Considering probands only, the presence of MEN1 was more frequently associated with PTH values in the normal range (OR, 3.01; 95% CI, 1.07\u20138.50; p = 0.037) and younger age (OR, 1.61; 95% CI, 1.28\u20132.02; p = 0.0001). A combination of PTH values in the normal range plus age &amp;lt;50 yr was strongly associated with MEN1 presence (OR, 13.51; 95% CI, 3.62\u201350.00; p = 0.0001). In conclusion, MEN1-related PHPT patients show more severe bone but similar kidney involvement despite a milder biochemical presentation compared with their sPHPT counterparts. Normal PTH levels and young age are associated with MEN1 presence.<\/jats:p>","DOI":"10.1359\/jbmr.090304","type":"journal-article","created":{"date-parts":[[2009,3,23]],"date-time":"2009-03-23T13:52:44Z","timestamp":1237816364000},"page":"1404-1410","source":"Crossref","is-referenced-by-count":136,"title":["Sporadic and MEN1-Related Primary Hyperparathyroidism: Differences in Clinical Expression and Severity"],"prefix":"10.1093","volume":"24","author":[{"given":"Cristina","family":"Eller-Vainicher","sequence":"first","affiliation":[{"name":"Unit of Endocrinology-Diabetology, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Chiodini","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology-Diabetology, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Battista","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, \u201cCasa Sollievo della Sofferenza,\u201d IRCCS, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Viti","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, \u201cCasa Sollievo della Sofferenza,\u201d IRCCS, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Mascia","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, University \u201cLa Sapienza,\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Massironi","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Peracchi","sequence":"additional","affiliation":[{"name":"Unit of Gastroenterology, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"D'Agruma","sequence":"additional","affiliation":[{"name":"Unit of Genetics, \u201cCasa Sollievo della Sofferenza,\u201d IRCCS, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Minisola","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, University \u201cLa Sapienza,\u201d University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Department of Medical and Surgical Sciences, University of Milan, IRCCS Policlinico San Donato Institute, San Donato Milanese, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David EC","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Spada","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology-Diabetology, Department of Medical Sciences, University of Milan, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Scillitani","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, \u201cCasa Sollievo della Sofferenza,\u201d IRCCS, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020319591107300_bib1","first-page":"25","article-title":"Epidemiology of primary hyperparathyroidism","volume":"6","author":"Melton","year":"1991","journal-title":"J Bone Miner Res"},{"key":"2024020319591107300_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0039-6060(97)90357-3","article-title":"Population-based screening for primary hyperparathyroidism with serum calcium and parathyroid hormone values in menopausal women","volume":"121","author":"Lundgren","year":"1997","journal-title":"Surgery"},{"key":"2024020319591107300_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/03009739909178956","article-title":"Primary hyperparathyroidism of postmenopausal women. 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