{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:54:09Z","timestamp":1793894049334,"version":"4.8.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Animal experiments show a dramatic improvement in skeletal repair by teriparatide. We tested the hypothesis that recombinant teriparatide, at the 20\u2009\u00b5g dose normally used for osteoporosis treatment or higher, would accelerate fracture repair in humans. Postmenopausal women (45 to 85 years of age) who had sustained a dorsally angulated distal radial fracture in need of closed reduction but no surgery were randomly assigned to 8 weeks of once-daily injections of placebo (n\u2009=\u200934) or teriparatide 20\u2009\u00b5g (n\u2009=\u200934) or teriparatide 40\u2009\u00b5g (n\u2009=\u200934) within 10 days of fracture. Hypotheses were tested sequentially, beginning with the teriparatide 40\u2009\u00b5g versus placebo comparison, using a gatekeeping strategy. The estimated median time from fracture to first radiographic evidence of complete cortical bridging in three of four cortices was 9.1, 7.4, and 8.8 weeks for placebo and teriparatide 20\u2009\u00b5g and 40\u2009\u00b5g, respectively (overall p\u2009=\u2009.015). There was no significant difference between the teriparatide 40\u2009\u00b5g versus placebo groups (p\u2009=\u2009.523). In post hoc analyses, there was no significant difference between teriparatide 40\u2009\u00b5g versus 20\u2009\u00b5g (p\u2009=\u2009.053); however, the time to healing was shorter in teriparatide 20\u2009\u00b5g than placebo (p\u2009=\u2009.006). The primary hypothesis that teriparatide 40\u2009\u00b5g would shorten the time to cortical bridging was not supported. The shortened time to healing for teriparatide 20\u2009\u00b5g compared with placebo still may suggest that fracture repair can be accelerated by teriparatide, but this result should be interpreted with caution and warrants further study. \u00a9 2010 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1359\/jbmr.090731","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T14:43:01Z","timestamp":1247496181000},"page":"404-414","source":"Crossref","is-referenced-by-count":441,"title":["Teriparatide for acceleration of fracture repair in humans: A prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures"],"prefix":"10.1093","volume":"25","author":[{"given":"Per","family":"Aspenberg","sequence":"first","affiliation":[{"name":"Orthopaedics, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry K","family":"Genant","sequence":"additional","affiliation":[{"name":"Synarc, Inc., San Francisco, CA, USA"},{"name":"University of California\u2013San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Johansson","sequence":"additional","affiliation":[{"name":"Orthopaedics, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J","family":"Nino","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungah","family":"See","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Krohn","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A","family":"Garc\u00eda-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Depto de Endocrinolog\u00eda, Centro de Osteoporosis, Hospital Universitario de Nuevo Le\u00f3n, Monterrey, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P","family":"Recknor","sequence":"additional","affiliation":[{"name":"United Osteoporosis Centers, Gainesville, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Einhorn","sequence":"additional","affiliation":[{"name":"Boston University Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail P","family":"Dalsky","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce 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