{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:28:13Z","timestamp":1789972093623,"version":"4.0.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2010,1,27]],"date-time":"2010-01-27T00:00:00Z","timestamp":1264550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The acute-phase response (APR) is the most frequent side effect after the first dose of intravenous nitrogen-containing bisphosphonates (N-BPs). It has been demonstrated in vitro that N-BPs stimulate \u03b3\u03b4 T-cell proliferation and production of cytokines and that vitamin D is able to modulate them. Therefore, we have studied the relationship between bone metabolism parameters, particularly for 25-hydroxyvitamin D [25(OH)D], and APR in patients treated with 5\u2009mg zoledronic acid intravenously. Ninety N-BP-naive osteoporotic women (63.7\u2009\u00b1\u200910.6 years of age) were stratified for the occurrence of APR (APR+) or not (APR\u2013) and quantified by body temperature and C-reactive protein (CRP). The APR+ women had significantly lower 25(OH)D levels than the APR\u2013 women. Levels of 25(OH)D were normal (&amp;gt;30\u2009ng\/mL) in 31% of APR+ women and in 76% of APR\u2013 women. The odds ratio (OR) to have APR in 25(OH)D-depleted women was 5.8 [95% confidence interval (CI) 5.30\u20136.29; p &amp;lt; .0002] unadjusted and 2.38 (95% CI 1.85\u20132.81; p &amp;lt; .028) after multiple adjustments (for age, body mass index, CRP, calcium, parathyroid hormone, and C-telopeptide of type I collagen). Levels of 25(OH)D were negatively correlated with postdose body temperature (r\u2009=\u2009\u22120.64, p\u2009&amp;lt;\u2009.0001) and CRP (r\u2009=\u2009\u22120.79, p\u2009&amp;lt;\u2009.001). An exponential increase in fever and CRP has been found with 25(OH)D levels lower than 30\u2009ng\/mL and body temperature less than 37\u2009\u00b0C, whereas normal CRP was associated with 25(OH)D levels above 40\u2009ng\/mL. The association between post-N-BPs APR and 25(OH)D suggests an interesting interplay among N-BPs, 25(OH)D, and the immune system, but a causal role of 25(OH)D in APR has to be proven by a randomized, controlled trial. However, if confirmed, it should have some practical implications in preventing APR. \u00a9 2010 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1359\/jbmr.090819","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T12:22:08Z","timestamp":1253794928000},"page":"447-454","source":"Crossref","is-referenced-by-count":85,"title":["Serum 25-hydroxyvitamin D levels modulate the acute-phase response associated with the first nitrogen-containing bisphosphonate infusion"],"prefix":"10.1093","volume":"25","author":[{"given":"Francesco","family":"Bertoldo","sequence":"first","affiliation":[{"name":"Department of Biochemical and Surgical Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Pancheri","sequence":"additional","affiliation":[{"name":"Department of Biochemical and Surgical Sciences, University of Verona, Verona, 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