{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:14:25Z","timestamp":1772169265258,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The relationship between osteoarthritis (OA) and osteoporosis remains controversial. This study was designed to determine the association between hip and knee radiographic OA and change in total hip bone mineral density (BMD) over 2.6 years. A total of 867 population-based randomly selected subjects (mean age 62 years, range 51 to 80 years, and 49% female) were included. Hip and knee joint space narrowing (JSN, 0 to 3) and osteophytes (0 to 3) in both lower limbs was assessed using Altman's atlas. Total hip BMD was measured by dual-energy X-ray absorptiometry (DXA). We found that radiographic OA (score of JSN or osteophytes &amp;gt; 0) was common in this sample (hip 45%, knee 68%). In multivariable analyses, percentage change in total hip BMD per year was predicted by right and left hip axial JSN (\u03b2\u2009=\u2009\u20130.25% and \u20130.29% per grade, respectively, both p\u2009&amp;lt;\u2009.05), right hip superior femoral osteophytes (grades 2 and 3 versus 0: \u03b2\u2009=\u2009\u20131.60, p\u2009&amp;lt;\u2009.05), combined right and left knee tibiofemoral JSN (\u03b2\u2009=\u2009\u20130.06 per grade from grades 0 to 12, p\u2009&amp;lt;\u2009.05), and osteophytes (\u03b2\u2009=\u2009\u20130.06 per grade from grades 0 to 14, p\u2009&amp;lt;\u2009.05) independent of each other and joint pain. In conclusion, older subjects with radiographic hip and knee OA have higher total hip bone loss over 2.6 years regardless of symptoms, suggesting that consideration should be given to the monitoring of bone mass in these subjects. \u00a9 2010 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1359\/jbmr.091012","type":"journal-article","created":{"date-parts":[[2009,10,12]],"date-time":"2009-10-12T18:34:50Z","timestamp":1255372490000},"page":"858-865","source":"Crossref","is-referenced-by-count":37,"title":["Knee and hip radiographic osteoarthritis predict total hip bone loss in older adults: A prospective study"],"prefix":"10.1093","volume":"25","author":[{"given":"Changhai","family":"Ding","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia"},{"name":"Menzies Research Institute, University of Tasmania, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Cicuttini","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catrina","family":"Boon","sequence":"additional","affiliation":[{"name":"Menzies Research Institute, University of Tasmania, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pip","family":"Boon","sequence":"additional","affiliation":[{"name":"Menzies Research Institute, University of Tasmania, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velandai","family":"Srikanth","sequence":"additional","affiliation":[{"name":"Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia"},{"name":"Menzies Research Institute, University of Tasmania, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Cooley","sequence":"additional","affiliation":[{"name":"Menzies Research Institute, University of Tasmania, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Jones","sequence":"additional","affiliation":[{"name":"Menzies Research Institute, University of Tasmania, Hobart, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,4,9]]},"reference":[{"key":"2024020401090955000_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/ard.31.4.259","article-title":"Bone density, osteoarthrosis of the hip, and fracture of the upper end of the femur","volume":"31","author":"Foss","year":"1972","journal-title":"Ann Rheum Dis."},{"key":"2024020401090955000_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/art.1780390111","article-title":"Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age; the Rotterdam Study","volume":"39","author":"Burger","year":"1996","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/rheumatology\/35.9.813","article-title":"Inverse relationship osteoarthritis-osteoporosis: what is the evidence? What are the consequences?","volume":"35","author":"Dequeker","year":"1996","journal-title":"Br J Rheumatol."},{"key":"2024020401090955000_bib4","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/art.1780361205","article-title":"Bone mineral density and knee osteoarthritis in elderly men and women: the Framingham Study","volume":"36","author":"Hannan","year":"1993","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/ard.53.3.158","article-title":"The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study","volume":"53","author":"Hart","year":"1994","journal-title":"Ann Rheum Dis."},{"key":"2024020401090955000_bib6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/art.1780380706","article-title":"Radiographic osteoarthritis of the hip and bone mineral density. The Study of Osteoporotic Fractures Research Group","volume":"38","author":"Nevitt","year":"1995","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/1529-0131(199904)42:3<483::AID-ANR13>3.0.CO;2-O","article-title":"The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women","volume":"42","author":"Sowers","year":"1999","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib8","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/1529-0131(199907)42:7<1378::AID-ANR11>3.0.CO;2-I","article-title":"Osteoarthritis and risk of falls, rates of bone loss, and osteoporotic fractures. Study of Osteoporotic Fractures Research Group","volume":"42","author":"Arden","year":"1999","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib9","first-page":"921","article-title":"Osteoarthritis, bone density, postural stability, and osteoporotic fractures: a population based study","volume":"22","author":"Jones","year":"1995","journal-title":"J Rheumatol."},{"key":"2024020401090955000_bib10","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/art.22088","article-title":"Knee pain, knee osteoarthritis, and the risk of fracture","volume":"55","author":"Arden","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib11","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/art.11380","article-title":"Osteoarthritis of the knee is associated with vertebral and nonvertebral fractures in the elderly: the Rotterdam Study","volume":"49","author":"Bergink","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.joca.2007.05.011","article-title":"Hand osteoarthritis and bone mineral density in postmenopausal women; clinical relevance to hand function, pain and disability","volume":"16","author":"El-Sherif","year":"2008","journal-title":"Osteoarthritis Cartilage."},{"key":"2024020401090955000_bib13","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1093\/rheumatology\/kei084","article-title":"Association of radiological hand osteoarthritis with bone mineral mass: a population study","volume":"44","author":"Haara","year":"2005","journal-title":"Rheumatology (Oxford)."},{"key":"2024020401090955000_bib14","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.joca.2003.09.008","article-title":"Bone mineral density and osteoarthritis: data from the Baltimore Longitudinal Study of Aging","volume":"12","author":"Hochberg","year":"2004","journal-title":"Osteoarthritis Cartilage."},{"key":"2024020401090955000_bib15","first-page":"1467","article-title":"Bone mineral density and clinical hand osteoarthritis in elderly men and women: the Rancho Bernardo study","volume":"29","author":"Schneider","year":"2002","journal-title":"J Rheumatol."},{"key":"2024020401090955000_bib16","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/01.gme.0000179048.08371.8e","article-title":"Osteoporosis and bone metabolism in postmenopausal women with osteoarthritis of the hand","volume":"13","author":"Zoli","year":"2006","journal-title":"Menopause."},{"key":"2024020401090955000_bib17","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1359\/jbmr.040904","article-title":"Disc space narrowing is associated with an increased vertebral fracture risk in postmenopausal women: the OFELY Study","volume":"19","author":"Sornay-Rendu","year":"2004","journal-title":"J Bone Miner Res."},{"key":"2024020401090955000_bib18","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/art.21737","article-title":"Disc space narrowing as a new risk factor for vertebral fracture: the OFELY study","volume":"54","author":"Sornay-Rendu","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib19","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s001980050281","article-title":"An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation","volume":"11","author":"Kanis","year":"2000","journal-title":"Osteoporos Int."},{"key":"2024020401090955000_bib20","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1001\/archinte.167.15.1641","article-title":"Single-site vs multisite bone density measurement for fracture prediction","volume":"167","author":"Leslie","year":"2007","journal-title":"Arch Intern Med."},{"key":"2024020401090955000_bib21","first-page":"3","article-title":"Atlas of individual radiographic features in osteoarthritis","volume":"3","author":"Altman","year":"1995","journal-title":"Osteoarthritis Cartilage."},{"key":"2024020401090955000_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.joca.2003.08.010","article-title":"Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females","volume":"12","author":"Jones","year":"2004","journal-title":"Osteoarthritis Cartilage."},{"key":"2024020401090955000_bib23","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy","year":"1988","journal-title":"J Rheumatol."},{"key":"2024020401090955000_bib24","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/00002281-200009000-00021","article-title":"Bone mineral density in osteoarthritis","volume":"12","author":"Stewart","year":"2000","journal-title":"Curr Opin Rheumatol."},{"key":"2024020401090955000_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/02841850601129015","article-title":"The influence of magnetic resonance imaging findings of degenerative disease on dual-energy X-ray absorptiometry measurements in middle-aged men","volume":"48","author":"Donescu","year":"2007","journal-title":"Acta Radiol."},{"key":"2024020401090955000_bib26","first-page":"932","article-title":"A longitudinal study of the effect of spinal degenerative disease on bone density in the elderly","volume":"22","author":"Jones","year":"1995","journal-title":"J Rheumatol."},{"key":"2024020401090955000_bib27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/bmj.307.6897.172","article-title":"Effect of spinal osteophytosis on bone mineral density measurements in vertebral osteoporosis","volume":"307","author":"Masud","year":"1993","journal-title":"Bmj."},{"key":"2024020401090955000_bib28","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1210\/jcem-70-4-1202","article-title":"The impact of osteophytic and vascular calcifications on vertebral mineral density measurements in men","volume":"70","author":"Orwoll","year":"1990","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020401090955000_bib29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/ard.2005.038414","article-title":"The relation between progressive osteoarthritis of the knee and long term progression of osteoarthritis of the hand, hip, and lumbar spine","volume":"65","author":"Hassett","year":"2006","journal-title":"Ann Rheum Dis."},{"key":"2024020401090955000_bib30","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1002\/art.11321","article-title":"Risk factors for progression of lumbar spine disc degeneration: the Chingford Study","volume":"48","author":"Hassett","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00198-004-1780-5","article-title":"Assessment of fracture risk","volume":"16","author":"Kanis","year":"2005","journal-title":"Osteoporos Int."},{"key":"2024020401090955000_bib32","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1002\/art.22160","article-title":"Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study","volume":"54","author":"Bingham","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2024020401090955000_bib33","doi-asserted-by":"crossref","first-page":"R625","DOI":"10.1186\/ar1716","article-title":"Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]","volume":"7","author":"Spector","year":"2005","journal-title":"Arthritis Res Ther."},{"key":"2024020401090955000_bib34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00002281-200103000-00004","article-title":"Genetic epidemiology of primary osteoarthritis","volume":"13","author":"Loughlin","year":"2001","journal-title":"Curr Opin Rheumatol."},{"key":"2024020401090955000_bib35","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1210\/jcem.87.6.8621","article-title":"Genetic control of susceptibility to osteoporosis","volume":"87","author":"Ralston","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020401090955000_bib36","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/BOR.0b013e32816e06f9","article-title":"The Wnt signaling pathway and bone metabolism","volume":"19","author":"Johnson","year":"2007","journal-title":"Curr Opin Rheumatol."},{"key":"2024020401090955000_bib37","first-page":"71","article-title":"Estrogen and osteoarthritis","volume":"33","author":"Gokhale","year":"2004","journal-title":"Am J Orthop."},{"key":"2024020401090955000_bib38","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J Clin Invest."},{"key":"2024020401090955000_bib39","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.33549\/physiolres.931499","article-title":"The effect of leptin on bone: an evolving concept of action","volume":"57","author":"Cirmanova","year":"2008","journal-title":"Physiol Res."},{"key":"2024020401090955000_bib40","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1136\/ard.2007.082651","article-title":"Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian Older Adult Cohort (TASOAC) study","volume":"67","author":"Ding","year":"2008","journal-title":"Ann Rheum Dis."},{"key":"2024020401090955000_bib41","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/jc.2007-2325","article-title":"Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study","volume":"93","author":"Ding","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020401090955000_bib42","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.joca.2006.10.010","article-title":"Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis","volume":"15","author":"Pearle","year":"2007","journal-title":"Osteoarthritis Cartilage."},{"key":"2024020401090955000_bib43","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/rheumatology\/keh171","article-title":"Association between knee cartilage volume and bone mineral density in older adults without osteoarthritis","volume":"43","author":"Cicuttini","year":"2004","journal-title":"Rheumatology (Oxford)."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1359%2Fjbmr.091012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/25\/4\/858\/56579881\/jbmr91012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/25\/4\/858\/56579881\/jbmr91012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:53:28Z","timestamp":1710327208000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/25\/4\/858-865\/7600327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,1]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,4,9]]},"published-print":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1359\/jbmr.091012","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3374959.3065058","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2010,4,1]]},"published":{"date-parts":[[2010,4,1]]}}}