{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T20:51:14Z","timestamp":1710449474643},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our previous work has shown that op\/op mice hyperabsorb dietary calcium in the vitamin D\u2013deficient state and shunt that calcium into bone. Under these conditions, the op\/op mice are hypocalcemic. The purpose of this study was to examine calcium metabolism and bone mineralization in vitamin D\u2013deficient op\/op mice. First, the op\/op mice and their normal littermates were placed on a vitamin D\u2013deficient, low phosphorus diet to limit bone mineralization. Under these circumstances, op\/op mice survived, even when calcium was also removed from the diet. If the diet contained phosphate, op\/op mice died from hypocalcemic tetany when calcium was also removed from the diet. Furthermore, serum calcium levels became similar to wild type in the op\/op mice administered the vitamin D\u2013deficient, low phosphorus diet, and op\/op mice were able to increase serum calcium in response to 1,25-dihydroxyvitamin D3. The op\/op mice developed rickets when their serum phosphorus level was too low to support bone mineralization. The op\/op mice became hypophosphatemic on regimens in which normal mice were able to maintain normal serum phosphorus levels. It appears that the op\/op mouse simply requires a higher dietary calcium and phosphorus level to prevent rickets and hypocalcemic tetany since the bone is not available as a source of these minerals. However, the ability of the op\/op mouse to mineralize bone at low serum calcium and phosphorus levels remains unexplained.<\/jats:p>","DOI":"10.1359\/jbmr.1997.12.11.1944","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T19:32:28Z","timestamp":1146079948000},"page":"1944-1951","source":"Crossref","is-referenced-by-count":5,"title":["Hypophosphatemia and the Development of Rickets in Osteopetrotic (<i>op\/op<\/i>) Mice"],"prefix":"10.1093","volume":"12","author":[{"given":"Laura C.","family":"Mccary","sequence":"first","affiliation":[{"name":"Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, Wisconsin, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, Wisconsin, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector F.","family":"Deluca","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin\u2013Madison, Madison, Wisconsin, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,4]]},"reference":[{"key":"2024020712011535900_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/00003086-197311000-00025","article-title":"Experimental osteopetrosis","volume":"97","author":"Walker","year":"1973","journal-title":"Clin Orthop"},{"key":"2024020712011535900_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/345442a0","article-title":"The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene","volume":"345","author":"Yoshida","year":"1990","journal-title":"Nature"},{"key":"2024020712011535900_bib3","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse","volume":"87","author":"Wiktor-Jedrzejczak","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024020712011535900_bib4","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1210\/endo-128-4-1792","article-title":"Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells","volume":"128","author":"Takahashi","year":"1991","journal-title":"Endocrinology"},{"key":"2024020712011535900_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jbmr.5650040109","article-title":"Treatment of congenital osteopetrosis in the rabbit with high-dose 1,25-dihydroxyvitamin D","volume":"4","author":"Popoff","year":"1989","journal-title":"J Bone Miner Res"},{"key":"2024020712011535900_bib6","first-page":"193","article-title":"Elevated serum 1,25-dihydroxyvitamin D in osteopetrotic mutations in three species","volume":"2","author":"Zerwekh","year":"1987","journal-title":"Bone Miner"},{"key":"2024020712011535900_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1056\/NEJM198402163100701","article-title":"Treatment of congenital osteopetrosis with high-dose calcitriol","volume":"310","author":"Key","year":"1984","journal-title":"N Engl J Med"},{"key":"2024020712011535900_bib8","first-page":"2211","article-title":"Vitamin D: The vitamin and hormone","volume":"33","author":"DeLuca","year":"1974","journal-title":"Fed Proc"},{"key":"2024020712011535900_bib9","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1073\/pnas.71.4.1040","article-title":"Role of 1,25-dihydroxyvitamin D3 in maintaining serum phosphorus and curing rickets","volume":"71","author":"Tanaka","year":"1974","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024020712011535900_bib10","first-page":"407","article-title":"An experimental investigation of rickets","volume":"1","author":"Mellanby","year":"1919","journal-title":"Lancet"},{"key":"2024020712011535900_bib11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9258(18)85783-0","article-title":"Studies on experimental rickets. 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