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At the end of the study, we found that: (1) the overall effectiveness of the treatment on bone mass in the tibial shaft indicates the following ranking: OVX\/PGE2\u2212240d = OVX\/c-PGE2+Ris &amp;gt; OVX\/c-PGE2 &amp;gt; OVX\/c-Ris \u2265 OVX = aging; (2) the same bone mass and architecture were produced in the OVX\/PGE2\u2212240d and the OVX\/c-PGE2+Ris groups, but the histomorphometric profiles differed in that the former exhibited a higher bone turnover and index of resorption; (3) OVX\/c-PGE2+Ris treatment prevented endocortical bone loss and minimized trabecular bone loss during the OFF periods; and (4) the OVX\/c-PGE2 alone treatment resulted in the accumulation of less total bone than OVX\/PGE2\u2212240d and OVX\/c-PGE2+Ris because it could not maintain most of the new subendocortical and marrow trabecular bone generated earlier. In summary, both continuous daily PGE2 and two cycles ON\/OFF combined PGE2 and Ris treatments result in more bone mass than two cycles ON\/OFF PGE2 alone and Ris alone in estrogen-deficient rats. This study showed that the anabolic effects of PGE2 can be induced and maintained either by continuous administration or by cyclical PGE2+Ris.<\/jats:p>","DOI":"10.1359\/jbmr.1997.12.12.2108","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T19:44:12Z","timestamp":1146080652000},"page":"2108-2112","source":"Crossref","is-referenced-by-count":6,"title":["Intermittent On\/Off Prostaglandin E2 and Risedronate Are Equally Anabolic as Daily PGE2 Alone Treatment in Cortical Bone of Ovariectomized Rats"],"prefix":"10.1093","volume":"12","author":[{"given":"Yan Fei","family":"Ma","sequence":"first","affiliation":[{"name":"Radiobiology Division, University of Utah School of Medicine, Salt Lake City, Utah, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng","family":"Pan","sequence":"additional","affiliation":[{"name":"Radiobiology Division, University of Utah School of Medicine, Salt Lake City, Utah, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Webster S. 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