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By contrast, the search for specific genes that regulate bone mass has progressed rather slowly, and the results are more difficult to interpret and reproduce. This article reviews the genetics of osteoporosis and problems plaguing genetic research. It is argued that the search for genes involved in the expression of osteoporotic phenotypes should be based on linkage studies in relatively homogeneous populations. Strategies for increasing the power of studies, such as making use of information from extended pedigrees and multivariate analysis, are discussed. With the advent of a comprehensive human genetic linkage map, a complete identification of genes for osteoporosis appears feasible. Understanding the genetic mechanisms and their interactions with environmental factors should allow more focused and cost-effective osteoporosis prevention and treatment strategies.<\/jats:p>","DOI":"10.1359\/jbmr.2000.15.3.392","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T02:14:02Z","timestamp":1146104042000},"page":"392-401","source":"Crossref","is-referenced-by-count":102,"title":["Genetic Epidemiological Approaches to the Search for Osteoporosis Genes"],"prefix":"10.1093","volume":"15","author":[{"given":"T. V.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Wright State University School of Medicine, Dayton, Ohio, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Blangero","sequence":"additional","affiliation":[{"name":"Southwest Foundation for Biomedical Research, San Antonio, Texas, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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