{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:30:49Z","timestamp":1792611049795,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fracture and immobilization of an extremity lead to bone loss at the fracture and at adjacent sites. We conducted a 1-year, single-center, prospective, randomized, double-blind study to determine whether bone loss would occur in the distal radius after a Colles' fracture and whether this loss could be prevented using an antiresorptive drug (alendronate). Thirty-seven women with a recent fracture of the distal forearm and low bone mineral density (BMD) of the lumbar spine were randomized to receive either 10 mg alendronate daily or placebo. BMD of both forearms was measured at baseline and after 3, 6, and 12 months. The results of four women who developed reflex sympathetic dystrophy were not included in the analysis. In the placebo group, there was a significant reduction at 3 months and 6 months in BMD of total radius (p &amp;lt; 0.01), one-third distal radius (p &amp;lt; 0.01), middistal radius (p &amp;lt; 0.05), and ultradistal radius (p &amp;lt; 0.01) on the fractured side. The loss in BMD at one-third distal radius remained significant at month 12 (p \u2264 0.001). In the alendronate group BMD of total distal radius, one-third distal radius, and middistal radius at the fractured side remained unchanged. BMD of ultradistal radius increased significantly at months 3, 6, and 12, compared with baseline (p &amp;lt; 0.05). The difference between the two treatment groups was significant at 3 months and 6 months and borderline significant (p = 0.054) after 1 year in total distal radius. In ultradistal radius the differences were significant at all time points. We conclude that BMD of the distal radius of a recently fractured forearm decreases significantly in the 6 months after fracture and the resulting deficit remains evident at least 1 year after fracture. This bone loss can be prevented by alendronate.<\/jats:p>","DOI":"10.1359\/jbmr.2000.15.3.586","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T02:14:02Z","timestamp":1146104042000},"page":"586-593","source":"Crossref","is-referenced-by-count":57,"title":["The Effect of Alendronate on Bone Mass After Distal Forearm Fracture"],"prefix":"10.1093","volume":"15","author":[{"given":"E.","family":"Van Der Poest Clement","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Academic Hospital Vrije Universiteit, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Patka","sequence":"additional","affiliation":[{"name":"Department of Traumatology, Academic Hospital Vrije Universiteit, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Vandormael","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Haarman","sequence":"additional","affiliation":[{"name":"Department of Traumatology, Academic Hospital Vrije Universiteit, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lips","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Academic Hospital Vrije Universiteit, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2,18]]},"reference":[{"key":"2024020714104098100_bib1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1136\/bmj.308.6943.1543","article-title":"Distal forearm fracture as a risk for vertebral osteoporosis","volume":"308","author":"Peel","year":"1994","journal-title":"BMJ"},{"issue":"Suppl 1","key":"2024020714104098100_bib2","first-page":"S82","article-title":"Increased risk of vertebral fracture in women with distal forearm fractures","volume":"52","author":"Peel","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"2024020714104098100_bib3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF01622198","article-title":"Distal radius fracture is an early sign of general osteoporosis: Bone mass measurements in a population-based study","volume":"4","author":"Mallmin","year":"1994","journal-title":"Osteoporos Int"},{"key":"2024020714104098100_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02352253","article-title":"Spine fracture risk is predicted by non-spine fractures","volume":"4","author":"Wasnich","year":"1994","journal-title":"Osteoporos Int"},{"key":"2024020714104098100_bib5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jbmr.5650090319","article-title":"Osteoporosis in men with a history of tibial fracture","volume":"9","author":"Kannus","year":"1994","journal-title":"J Bone Miner Res"},{"key":"2024020714104098100_bib6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1302\/0301-620X.77B3.7744940","article-title":"Bone loss after tibial fracture","author":"Eyres","year":"1995","journal-title":"J Bone Joint Surg Br"},{"key":"2024020714104098100_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2106\/00004623-199402000-00009","article-title":"Loss of bone in the proximal part of the femur following unstable fractures of the leg","volume":"76A","author":"Van der Wiel","year":"1994","journal-title":"J Bone Joint Surg Am"},{"key":"2024020714104098100_bib8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00003086-197407000-00023","article-title":"Loss of bone mineral after Colles' fracture","volume":"102","author":"Westlin","year":"1974","journal-title":"Clin Orthop"},{"key":"2024020714104098100_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/17453677508989192","article-title":"Long-term observations on the loss of bone mineral following Colles' fracture","volume":"46","author":"Nilsson","year":"1975","journal-title":"Acta Orthop Scand"},{"key":"2024020714104098100_bib10","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3109\/17453679209154736","article-title":"Colles' fracture associated with reduced bone mineral content. 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