{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:01:43Z","timestamp":1762671703433},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vertebral fractures (VFX) are caused by low bone mass and microstructural deterioration of bone tissue. The latter is not well defined. We investigated bone structure in transiliac biopsy specimens from 88 volunteers. Biopsy specimens were obtained at baseline in the Multiple Outcomes of Raloxifene Evaluation trial, a prospective study in osteoporotic (BMD \u2264 \u22122.5 T score) postmenopausal women without or with VFX on standardized lateral spinal radiographs. Bone biopsy specimens were embedded in methylmethacrylate (MMA). Histomorphometry was done in 8 \u03bcm (U.S.A.) or 5 \u03bcm (Europe) Goldner stained sections. Vertebral fracture status (yes\/no) was the outcome variable in logistic regression models adjusted for age and biopsy specimen origin (U.S.A. vs. Europe). Patients with and without VFX (26\/62) were similar regarding age (69.2 \u00b1 5.2 years vs. 67.3 \u00b1 6.7 years), bone volume (BV\/TV; 17.7 \u00b1 4.7% vs. 19.0 \u00b1 5.8%), and bone surface (BS\/TV; 2.7 \u00b1 0.6 mm2\/mm3 vs. 2.8 \u00b1 0.6 mm2\/mm3). A lower cortical thickness (C.Th; 652 \u00b1 267 \u03bcm vs. 822 \u00b1 325 \u03bcm), total strut length (TSL; 826 \u00b1 226 \u03bcm\/mm2 vs. 922 \u00b1 256 \u03bcm\/mm2), node-to-loop (Nd-Lp) strut length (10.1 \u00b1 10.3% vs. 15.0 \u00b1 13.6%), together with a higher node-to-terminus (Nd-Tm) strut length (45.6 \u00b1 9.7% vs. 39.1 \u00b1 9.3%) were each associated with prevalent VFX (0.01 &amp;lt; p &amp;lt; 0.10). Differences in BV\/TV did not explain these associations. In conclusion, cortical thinning and disruption of trabecular lattice are possible pathogenic mechanisms in patients with VFX.<\/jats:p>","DOI":"10.1359\/jbmr.2000.15.7.1368","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T20:30:23Z","timestamp":1146083423000},"page":"1368-1375","source":"Crossref","is-referenced-by-count":86,"title":["Bone Structure in Patients with Low Bone Mineral Density With or Without Vertebral Fractures"],"prefix":"10.1093","volume":"15","author":[{"given":"Anna","family":"Oleksik","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Ott","sequence":"additional","affiliation":[{"name":"Division of Metabolism, University of Washington, Seattle, Washington, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shobna","family":"Vedi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Bravenboer","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet","family":"Compston","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lips","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Academic Hospital Vrije Universiteit, Amsterdam, The 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