{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:55:28Z","timestamp":1790646928868,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The parathyroid hormone\/parathyroid hormone-related peptide (PTH\/PTHrP) receptor (denoted as PTH-1R) is a key signaling factor through which calcium-regulating hormones PTH and PTHrP exert their effects on bone. There are contradictory reports regarding the capability of osteoclasts to express PTH-1R. To address this issue in humans, bone biopsy specimen samples from 9 normal controls and 16 patients with moderate to severe secondary renal hyperparathyroid bone disease (2\u00b0HPT) with elevated PTH levels were studied to determine whether osteoclasts in the bone microenvironment express PTH-1R messenger RNA (mRNA) and protein. We report that osteoclasts express the PTH-1R mRNA but the protein is detected only in patients with 2\u00b0HPT. The PTH-1R mRNA and protein also were found in osteoblasts, osteocytes, and bone marrow cells. Receptor expression was higher in osteoclasts and osteoblasts of patients with 2\u00b0HPT than normal controls (98.0 \u00b1 1.1% vs. 65.7 \u00b1 14.3% and 65.8 \u00b1 3.4% vs. 39.1 \u00b1 6.2%; p &amp;lt; 0.01, respectively). Approximately half of osteoclasts found in bone of patients with 2\u00b0HPT have the PTH-1R protein. In patients with 2\u00b0HPT, a positive relationship exists between erosion depth, a parameter of osteoclastic activity, and the percentage of osteoclasts with PTH-1R protein (r = 0.58; p &amp;lt; 0.05). In normal controls, an inverse relationship exists between the percentage of osteoblasts with receptor mRNA, mRNA signals\/cell, and serum PTH levels (r = \u22120.82 and p &amp;lt; 0.05 and r = \u22120.78 and p &amp;lt; 0.01, respectively). The results provide the novel evidence of PTH-1R in human osteoclasts and suggest a functional role for the receptors in 2\u00b0HPT.<\/jats:p>","DOI":"10.1359\/jbmr.2001.16.3.448","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T03:50:54Z","timestamp":1146109854000},"page":"448-456","source":"Crossref","is-referenced-by-count":56,"title":["Parathyroid Hormone\/Parathyroid Hormone-Related Peptide Type 1 Receptor in Human Bone"],"prefix":"10.1093","volume":"16","author":[{"given":"M. Chris","family":"Langub","sequence":"first","affiliation":[{"name":"Division of Nephrology, Bone and Mineral Metabolism, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Monier-Faugere","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Bone and Mineral Metabolism, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanle","family":"Qi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Bone and Mineral Metabolism, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Geng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Bone and Mineral Metabolism, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Koszewski","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Bone and Mineral Metabolism, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut H.","family":"Malluche","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Bone and Mineral Metabolism, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024020714133205600_bib1","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1073\/pnas.89.7.2732","article-title":"Expression cloning of a common receptor for PTH and parathyroid hormone-related peptide from rat osteoblast-like cells: A single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium","volume":"89","author":"Abou-Samra","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024020714133205600_bib2","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1210\/endo.132.5.8386606","article-title":"Cloned, stably expressed parathyroid hormone (PTH)\/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells","volume":"132","author":"Bringhurst","year":"1993","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib3","first-page":"F223","article-title":"PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney","volume":"258","author":"Dunlay","year":"1990","journal-title":"Am J Physiol"},{"key":"2024020714133205600_bib4","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.1658941","article-title":"A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide","volume":"254","author":"Juppner","year":"1991","journal-title":"Science"},{"key":"2024020714133205600_bib5","first-page":"11","article-title":"Characterization of cloned PTH\/PTHrP receptors","volume":"15","author":"Segre","year":"1992","journal-title":"J Endocrinol Invest"},{"key":"2024020714133205600_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1677\/joe.0.1530123","article-title":"Parathyroid hormone\/parathyroid hormone-related protein receptor expression in nude mice with a transplantable canine apocrine adenocarcinoma (CAC-8) and humoral hypercalcaemia of malignancy","volume":"153","author":"Grone","year":"1997","journal-title":"J Endocrinol"},{"key":"2024020714133205600_bib7","first-page":"F186","article-title":"Localization of parathyroid hormone\/parathyroid hormone-related peptide receptor mRNA in kidney","volume":"270","author":"Lee","year":"1996","journal-title":"Am J Physiol"},{"key":"2024020714133205600_bib8","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1210\/endo.137.11.8895385","article-title":"Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development","volume":"137","author":"Lee","year":"1996","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000168620","article-title":"Parathyroid hormone-parathyroid hormone related protein receptor messenger RNA is present in many tissues besides the kidney","volume":"13","author":"Tian","year":"1993","journal-title":"Am J Nephrol"},{"key":"2024020714133205600_bib10","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1093\/oxfordjournals.ndt.a027089","article-title":"PTH\/PTHrP receptor mRNA is down-regulated in epiphyseal cartilage growth plate of uraemic rats","volume":"11","author":"Urena","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"2024020714133205600_bib11","first-page":"51","volume-title":"Principles of Bone Biology","author":"Aubin","year":"1996"},{"key":"2024020714133205600_bib12","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1074\/jbc.271.18.10984","article-title":"Stimulation by parathyroid hormone of interleukin-6 and leukemia inhibitory factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction","volume":"271","author":"Greenfield","year":"1996","journal-title":"J Biol Chem"},{"key":"2024020714133205600_bib13","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/jbmr.5650111003","article-title":"Parathyroid hormone regulates osteoblast differentiation positively or negatively depending on the differentiation stages","volume":"11","author":"Isogai","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib14","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/(SICI)1097-4644(19960616)61:4<638::AID-JCB18>3.0.CO;2-B","article-title":"PTH\/PTHrP receptor is temporally regulated during osteoblast differentiation and is associated with collagen synthesis","volume":"61","author":"McCauley","year":"1996","journal-title":"J Cell Biochem"},{"key":"2024020714133205600_bib15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/jbmr.5650110606","article-title":"In vivo demonstration that parathyroid hormone and parathyroid hormone- related protein stimulate expression by osteoblasts of interleukin-6 and leukemia inhibitory factor","volume":"11","author":"Pollock","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib16","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/endo-116-1-234","article-title":"The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones","volume":"116","author":"Chambers","year":"1985","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib17","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/jbmr.5650101213","article-title":"PTH\/PTHrP receptor expression on osteoblasts and osteocytes but not resorbing bone surfaces in growing rats","volume":"10","author":"Fermor","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/jbmr.5650070509","article-title":"Specific binding of parathyroid hormone to living osteoclasts","volume":"7","author":"Agarwala","year":"1992","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1677\/joe.0.1490269","article-title":"Parathyroid hormone induces superoxide anion burst in the osteoclast: Evidence for the direct instantaneous activation of the osteoclast by the hormone","volume":"149","author":"Datta","year":"1996","journal-title":"J Endocrinol"},{"key":"2024020714133205600_bib20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/(SICI)1097-4644(19970615)65:4<565::AID-JCB11>3.0.CO;2-B","article-title":"Parathyroid hormone uses both adenylate cyclase and protein kinase C to regulate acid production in osteoclasts","volume":"65","author":"May","year":"1997","journal-title":"J Cell Biochem"},{"key":"2024020714133205600_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/(SICI)1097-4644(199701)64:1<161::AID-JCB18>3.0.CO;2-O","article-title":"Multiple G-protein involvement in parathyroid hormone regulation of acid production by osteoclasts","volume":"64","author":"May","year":"1997","journal-title":"J Cell Biochem"},{"key":"2024020714133205600_bib22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1210\/endo-113-2-805","article-title":"Immunohistochemical demonstration of parathyroid hormone binding to specific cell types in fixed rat bone tissue","volume":"113","author":"Rao","year":"1983","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib23","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650051008","article-title":"Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones","volume":"5","author":"Rouleau","year":"1990","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1210\/endo-118-3-919","article-title":"Parathyroid hormone binding in vivo to renal, hepatic, and skeletal tissues of the rat using a radioautographic approach","volume":"118","author":"Rouleau","year":"1986","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib25","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/0006-291X(91)91551-M","article-title":"Parathyroid hormone binding to cultured avian osteoclasts","volume":"174","author":"Teti","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"2024020714133205600_bib26","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/jbmr.5650110905","article-title":"Down-regulation of the receptor for parathyroid hormone (PTH) and PTH-related peptide by PTH in primary fetal rat osteoblasts","volume":"11","author":"Jongen","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib27","first-page":"S483","article-title":"Effects of dietary calcium and calcitriol administration on the levels of parathyroid hormone, serum calcium, and PTH receptor mRNA in vitamin D deficient rats","volume":"10","author":"Gonzalez","year":"1996","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib28","first-page":"548A","article-title":"Uraemic compounds and osteoblast expression of PTH\/PTHrP mRNA","volume":"9","author":"Picton","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"2024020714133205600_bib29","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1210\/endo.136.9.7649081","article-title":"Parathyroid hormone (PTH)\/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency","volume":"136","author":"Turner","year":"1995","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib30","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1046\/j.1523-1755.1999.00230.x","article-title":"Proliferation of parathyroid cells negatively correlates with expression of parathyroid hormone-related protein in secondary parathyroid hyperplasia","volume":"55","author":"Matsushita","year":"1999","journal-title":"Kidney Int"},{"key":"2024020714133205600_bib31","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1210\/endo-118-3-932","article-title":"Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex","volume":"118","author":"Nissenson","year":"1986","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1073\/pnas.84.1.26","article-title":"Immunoprecipitation of the parathyroid hormone receptor","volume":"84","author":"Wright","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024020714133205600_bib33","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/jbmr.5650061210","article-title":"A new method for measuring cancellous bone erosion depth. Application to the cellular mechanisms of bone loss in post-menopausal osteoporosis","volume":"6","author":"Cohen-Solal","year":"1991","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib34","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/(SICI)1096-9896(199609)180:1<80::AID-PATH617>3.0.CO;2-A","article-title":"Expression of parathyroid hormone (PTH)-related peptide (PTHrP) and PTH\/PTHrP receptor in giant cell tumour of tendon sheath","volume":"180","author":"Nakashima","year":"1996","journal-title":"J Pathol"},{"key":"2024020714133205600_bib36","first-page":"S322","article-title":"Osteoclasts respond to parathyroid hormone and express mRNA for its receptor","volume":"10","author":"Tong","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib37","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1359\/jbmr.1998.13.5.854","article-title":"Estrogen via the estrogen receptor blocks cAMP-mediated parathyroid hormone (PTH)-stimulated osteoclast formation","volume":"13","author":"Kanatani","year":"1998","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1210\/endo.134.1.8275957","article-title":"Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: In situ localization of its receptor and c-fos messenger ribonucleic acids","volume":"134","author":"Lee","year":"1994","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib39","first-page":"1066","article-title":"Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)\/PTH-related peptide receptor messenger RNA in human kidney and bone cells","volume":"10","author":"Jobert","year":"1996","journal-title":"Mol Endocrinol"},{"key":"2024020714133205600_bib40","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1172\/JCI3678","article-title":"Developmental upregulation of human parathyroid hormone (PTH)\/PTH-related peptide receptor gene expression from conserved and human-specific promoters","volume":"102","author":"Bettoun","year":"1998","journal-title":"J Clin Invest"},{"key":"2024020714133205600_bib41","first-page":"1031","article-title":"Cloning and characterization of the promoter regions of the human parathyroid hormone (PTH)\/PTH-related peptide receptor gene: Analysis of deoxyribonucleic acid from normal subjects and patients with pseudohypoparathyroidism type 1b","volume":"82","author":"Bettoun","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2024020714133205600_bib42","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1210\/endo.138.4.5085","article-title":"Tissue-specific transcription start sites and alternative splicing of the parathyroid hormone (PTH)\/PTH-related peptide (PTHrP) receptor gene: A new PTH\/PTHrP receptor splice variant that lacks the signal peptide","volume":"138","author":"Joun","year":"1997","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib43","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/nar\/23.11.1948","article-title":"Parathyroid hormone\/parathyroid hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiquitous promoters","volume":"23","author":"McCuaig","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"2024020714133205600_bib44","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1093\/nar\/22.22.4599","article-title":"Heterogeneity in the 5\u2032 untranslated region of mouse cytochrome cT mRNAs leads to altered translational status of the mRNAs","volume":"22","author":"Yiu","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"2024020714133205600_bib45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1055\/s-2007-978689","article-title":"Serum interleukin-6 in renal osteodystrophy: Relationship with serum PTH and bone remodeling markers","volume":"31","author":"Montalban","year":"1999","journal-title":"Horm Metab Res"},{"key":"2024020714133205600_bib46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ki.1996.343","article-title":"Bone resorption and mRNA expression of IL-6 and IL-6 receptor in patients with renal osteodystrophy","volume":"50","author":"Langub","year":"1996","journal-title":"Kidney Int"},{"key":"2024020714133205600_bib47","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/(SICI)1097-4644(19961201)63:3<374::AID-JCB13>3.0.CO;2-H","article-title":"Parathyroid hormone regulates the expression of rat osteoblast and osteosarcoma nuclear matrix proteins","volume":"63","author":"Bidwell","year":"1996","journal-title":"J Cell Biochem"},{"key":"2024020714133205600_bib48","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/jbmr.5650100609","article-title":"Cell-to-cell communication in osteoblastic networks: Cell line-dependent hormonal regulation of gap junction function","volume":"10","author":"Donahue","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ki.1996.287","article-title":"Coordinate regulation of PTH\/PTHrP receptors by PTH and calcitriol in UMR 106-01 osteoblast-like cells","volume":"50","author":"Gonzalez","year":"1996","journal-title":"Kidney Int"},{"key":"2024020714133205600_bib50","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1210\/endo.139.7.6089","article-title":"The effect of cell-matrix interaction on parathyroid hormone (PTH) receptor binding and PTH responsiveness in proximal renal tubular cells and osteoblast-like cells","volume":"139","author":"Tam","year":"1998","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib51","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jbmr.5650060614","article-title":"1,25-dihydroxyvitamin D reduces parathyroid hormone receptor number in ROS 17\/2.8 cells and prevents the glucocorticoid-induced increase in these receptors: Relationship to adenylate cyclase activation","volume":"6","author":"Titus","year":"1991","journal-title":"J Bone Miner Res"},{"issue":"4 Pt 1","key":"2024020714133205600_bib52","first-page":"E654","article-title":"Downregulation of the PTH\/PTHrP receptor by vitamin D3 in the osteoblast-like ROS 17\/2.8 cells","volume":"270","author":"Xie","year":"1996","journal-title":"Am J Physiol"},{"key":"2024020714133205600_bib53","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1210\/endo.133.2.8393771","article-title":"Parathyroid hormone (PTH)\/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues","volume":"133","author":"Urena","year":"1993","journal-title":"Endocrinology"},{"key":"2024020714133205600_bib54","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/BF00866780","article-title":"Abnormal skeletal response to parathyroid hormone and the expression of its receptor in chronic uremia","volume":"10","author":"Drueke","year":"1996","journal-title":"Pediatr Nephrol"},{"key":"2024020714133205600_bib55","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/jbmr.5650091105","article-title":"Characteristics and properties of osteocytes in culture","volume":"9","author":"van der Plas","year":"1994","journal-title":"J Bone Miner Res"},{"key":"2024020714133205600_bib56","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1083\/jcb.60.2.346","article-title":"The effects of parathyroid hormone, colchicine, and calcitonin on the ultrastructure and the activity of osteoclasts in organ cultures","volume":"60","author":"Holtrop","year":"1974","journal-title":"J Cell Biol"},{"key":"2024020714133205600_bib57","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF02547282","article-title":"Daily fluctuations in plasma calcium, phosphate and their radionucleotide concentrations in the rat","volume":"17","author":"Talmage","year":"1975","journal-title":"Calcif Tissue Res"},{"key":"2024020714133205600_bib58","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0026-0495(76)90151-7","article-title":"The action of parathyroid hormone on bone: Relationship to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part I of IV parts: Mechanisms of calcium transfer between blood and bone and their cellular basis: Morphological and kinetic approaches to bone turnover","volume":"25","author":"Parfitt","year":"1976","journal-title":"Metabolism"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1359%2Fjbmr.2001.16.3.448","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/16\/3\/448\/56605562\/5650160304.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/16\/3\/448\/56605562\/5650160304.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:02:23Z","timestamp":1710342143000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/16\/3\/448-456\/7515922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,1]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,12,2]]},"published-print":{"date-parts":[[2001,3,1]]}},"URL":"https:\/\/doi.org\/10.1359\/jbmr.2001.16.3.448","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2001,3,1]]},"published":{"date-parts":[[2001,3,1]]}}}