{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:08:48Z","timestamp":1791223728332,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ultrasound technology has emerged as a new tool in the assessment of osteoporosis. Ultrasound parameters usually are measured in transmission; there is a potential for the analysis of backscattered signals to provide information on bone microarchitecture. The aim of this study was to explore a new technological development of the method, adding backscatter coefficient to transmission parameters, and to examine the appropriate thresholds to identify postmenopausal osteoporotic women. We examined 210 postmenopausal women (including 60 with osteoporotic fractures) and 30 healthy premenopausal controls. They had lumbar spine and hip bone mineral density (BMD) measurement and quantitative ultrasound (QUS) evaluation at the os calcis, measured in transmission (broadband ultrasound attenuation [BUA], speed of sound [SOS], ratio of transit time [dt] to BUA [dt\/BUA], and \u201cstrength\u201d index [STI]) and reflexion (broadband ultrasound backscattering [BUB]). The standardized CVs (sCVs) were between 2.27% and 3.40% for QUS measured in transmission and 4.41% for BUB. The odds ratio (OR) for fracture discrimination adjusted for age was 2.77 for hip BMD and between 1.6 and 2.9 for QUS. After adjustment for hip BMD, ORs were still highly significant for SOS, STI, and dt\/BUA. According to hip BMD T score, prevalence of osteoporosis in our population was 39%. To detect the same prevalence, T scores ranged between \u22120.95 and \u22121.42 for QUS. QUS parameters have adequate ability to discriminate osteoporotic patients from controls. The World Health Organization (WHO) threshold for diagnosis of osteoporosis does not apply to this technology. The clinical utility of BUB at the os calcis, in addition to usual ultrasound parameters, is not yet proven. However, BUB evaluation, which does not require two transducers and may be implemented in conventional reflection mode systems, warrants further studies.<\/jats:p>","DOI":"10.1359\/jbmr.2001.16.7.1353","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T04:29:33Z","timestamp":1146112173000},"page":"1353-1362","source":"Crossref","is-referenced-by-count":87,"title":["Ultrasonic Backscatter and Transmission Parameters at the Os Calcis in Postmenopausal Osteoporosis"],"prefix":"10.1093","volume":"16","author":[{"given":"Christian","family":"Roux","sequence":"first","affiliation":[{"name":"Centre d'Evaluation des Maladies Osseuses, D\u00e9partement de Rhumatologie, H\u00f4pital Cochin, Universit\u00e9 Ren\u00e9 Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ry","family":"Roberjot","sequence":"additional","affiliation":[{"name":"Laboratoire d'Imagerie Param\u00e9trique-Unit\u00e9 Mixte de Recherche Centre National de la Recherche Scientifique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Porcher","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biostatistique et Informatique M\u00e9dicale, H\u00f4pital Saint-Louis, Universit\u00e9 Paris VII, and Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Kolta","sequence":"additional","affiliation":[{"name":"Centre d'Evaluation des Maladies Osseuses, D\u00e9partement de Rhumatologie, H\u00f4pital Cochin, Universit\u00e9 Ren\u00e9 Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[{"name":"Centre d'Evaluation des Maladies Osseuses, D\u00e9partement de Rhumatologie, H\u00f4pital Cochin, Universit\u00e9 Ren\u00e9 Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Laugier","sequence":"additional","affiliation":[{"name":"Laboratoire d'Imagerie Param\u00e9trique-Unit\u00e9 Mixte de Recherche Centre National de la Recherche Scientifique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024020714125169500_bib1","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1359\/jbmr.1997.12.8.1280","article-title":"Quantitative ultrasound techniques for the assessment of osteoporosis: Expert agreement on current status","volume":"12","author":"Gl\u00fcer","year":"1997","journal-title":"J Bone Miner Res"},{"key":"2024020714125169500_bib2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/bmj.301.6753.638","article-title":"Prediction of hip fracture in elderly women: A prospective study","volume":"301","author":"Porter","year":"1990","journal-title":"BMJ"},{"key":"2024020714125169500_bib3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0140-6736(95)11456-4","article-title":"Ultrasonographic heel measurements to predict hip fracture in elderly women: The EPIDOS Prospective Study","volume":"348","author":"Hans","year":"1996","journal-title":"Lancet"},{"key":"2024020714125169500_bib4","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1148\/radiology.199.3.8637996","article-title":"Osteoporosis: Association of recent fractures with quantitative U.S. findings","volume":"199","author":"Gl\u00fcer","year":"1996","journal-title":"Radiology"},{"key":"2024020714125169500_bib5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/archinte.1997.00440270067006","article-title":"Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women: A prospective study. 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