{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:59:24Z","timestamp":1791291564293,"version":"4.3.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Increased local osteoclast (OC)-mediated bone resorption coincides with angiogenesis in normal bone development and fracture repair, as well as in pathological disorders such as tumor-associated osteolysis and inflammatory-related rheumatoid arthritis or periodontal disease. Angiogenic stimulation causes recruitment, activation, adhesion, transmigration, and differentiation of hematopoietic cells which may therefore enable greater numbers of pre-OC to emigrate from the circulation and develop into bone-resorptive OCs. A chick chorioallantoic membrane (CAM) model, involving coimplantation of a stimulus in an agarose plug directly adjacent to a bone chip was used to investigate if a potent angiogenic stimulator, basic fibroblast growth factor (bFGF), could promote OC recruitment, differentiation, and resorption in vivo. Angiogenesis elicited by bFGF on the CAM was accompanied by increased OC formation and bone pit resorption (both overall and on a per OC basis) on the bone implants in vivo. In complementary in vitro assays, bFGF did not directly stimulate avian OC development from bone marrow mononuclear cell precursors, consistent with their low mRNA expression of the four avian signaling FGF receptors (FGFR)-1, FGFR-2, FGFR-3, and FGFR-like embryonic kinase (FREK). In contrast, bFGF activated isolated avian OC bone pit resorption via mechanisms inhibited by a selective cyclo-oxygenase (COX)-2 prostaglandin inhibitor (NS-398) or p42\/p44 MAPK activation inhibitor (PD98059), consistent with a relatively high expression of FGFR-1 by differentiated avian OCs. Thus, bFGF may sensitively regulate local bone resorption and remodeling through direct and indirect mechanisms that promote angiogenesis and OC recruitment, formation, differentiation, and activated bone pit resorption. The potential for bFGF to coinduce angiogenesis and OC bone remodeling may find clinical applications in reconstructive surgery, fracture repair, or the treatment of avascular necrosis. Alternatively, inhibiting such bFGF-dependent processes may aid in the treatment of inflammatory-related or metastatic bone loss.<\/jats:p>","DOI":"10.1359\/jbmr.2002.17.10.1859","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T04:41:19Z","timestamp":1146112879000},"page":"1859-1871","source":"Crossref","is-referenced-by-count":97,"title":["Basic Fibroblast Growth Factor Stimulates Osteoclast Recruitment, Development, and Bone Pit Resorption in Association With Angiogenesis In Vivo on the Chick Chorioallantoic Membrane and Activates Isolated Avian Osteoclast Resorption In Vitro"],"prefix":"10.1093","volume":"17","author":[{"given":"Patricia","family":"Collin-Osdoby","sequence":"first","affiliation":[{"name":"Division of Bone and Mineral Research, Washington University, St. Louis, Missouri, USA"},{"name":"Department of Biology, Washington University, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Rothe","sequence":"additional","affiliation":[{"name":"Department of Biology, Washington University, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bekker","sequence":"additional","affiliation":[{"name":"Department of Biology, Washington University, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Biology, Washington University, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biology, Washington University, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Osdoby","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Research, Washington University, St. Louis, Missouri, USA"},{"name":"Department of Biology, Washington University, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024013019064554700_bib1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0955-2235(89)90012-4","article-title":"The fibroblast growth factor family: Structural and biological properties","volume":"1","author":"Klagsbrun","year":"1989","journal-title":"Prog Growth Factor Res"},{"key":"2024013019064554700_bib2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0092-8674(94)90520-7","article-title":"The ins and outs of fibroblast growth factors","volume":"78","author":"Mason","year":"1994","journal-title":"Cell"},{"key":"2024013019064554700_bib3","first-page":"26","article-title":"Biological roles of fibroblast growth factor-2","volume":"18","author":"Bikfalvi","year":"1997","journal-title":"Endocr Rev"},{"key":"2024013019064554700_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0065-230X(08)60305-X","article-title":"The FGF family of growth factors and oncogenes","volume":"59","author":"Basilico","year":"1992","journal-title":"Adv Cancer Res"},{"key":"2024013019064554700_bib5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-0348-9006-9_7","article-title":"Fibroblast growth factors as angiogenesis factors: New insights into their mechanism of action","volume":"79","author":"Klein","year":"1997","journal-title":"Experientia Suppl"},{"key":"2024013019064554700_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1096\/fasebj.11.6.9194526","article-title":"The codependence of angiogenesis and chronic inflammation","volume":"11","author":"Jackson","year":"1997","journal-title":"FASEB J"},{"key":"2024013019064554700_bib7","first-page":"150","article-title":"New factors controlling bone remodeling","volume":"67","author":"Marie","year":"2000","journal-title":"Joint Bone Spine"},{"key":"2024013019064554700_bib8","first-page":"83","article-title":"Recent advances in bone biology provide insight into the pathogenesis of bone diseases","volume":"79","author":"Boyce","year":"1999","journal-title":"Lab Invest"},{"key":"2024013019064554700_bib9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1359-6101(96)00039-1","article-title":"Functions of fibroblast growth factors in vertebrate development","volume":"7","author":"Goldfarb","year":"1996","journal-title":"Cytokine Growth Factor Rev"},{"key":"2024013019064554700_bib10","doi-asserted-by":"crossref","first-page":"11895","DOI":"10.1073\/pnas.96.21.11895","article-title":"Fgfr2 is required for limb outgrowth and lung-branching morphogenesis","volume":"96","author":"Arman","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024013019064554700_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0925-4773(98)00133-6","article-title":"Spatio-temporal expression of FGFR 1, 2, and 3 genes during human embryo-fetal ossification","volume":"77","author":"Delezoide","year":"1998","journal-title":"Mech Dev"},{"key":"2024013019064554700_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S8756-3282(98)00191-4","article-title":"Differential expression of fibroblast growth factor receptor-1, -2, and -3 and syndecan-1, -2, and -4 in neonatal rat mandibular condyle and calvaria during osteogenic differentiation in vitro","volume":"24","author":"Molteni","year":"1999","journal-title":"Bone"},{"key":"2024013019064554700_bib13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0168-9525(97)01131-1","article-title":"FGFR activation in skeletal disorders: Too much of a good thing","volume":"13","author":"Webster","year":"1997","journal-title":"Trends Genet"},{"key":"2024013019064554700_bib14","first-page":"23","article-title":"The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: The achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans","volume":"21","author":"Vajo","year":"2000","journal-title":"Endocr Rev"},{"key":"2024013019064554700_bib15","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1210\/endo-124-3-1539","article-title":"Cultured bovine bone cells synthesize fibroblast growth factor and store it in their extracellular matrix","volume":"124","author":"Globus","year":"1989","journal-title":"Endocrinology"},{"key":"2024013019064554700_bib16","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1096\/fasebj.13.13.1677","article-title":"FGF-2\/fibroblast growth factor receptor\/heparin-like glycosaminoglycan interactions: A compensation model for FGF-2 signaling","volume":"13","author":"Padera","year":"1999","journal-title":"FASEB J"},{"key":"2024013019064554700_bib17","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1016\/S8756-3282(99)00044-7","article-title":"Cellular and molecular regulation of bone turnover","volume":"24","author":"Mundy","year":"1999","journal-title":"Bone"},{"key":"2024013019064554700_bib18","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/nm1097-1137","article-title":"A secreted FGF-binding protein can serve as the angiogenic switch in human cancer","volume":"3","author":"Czubayko","year":"1997","journal-title":"Nat Med"},{"key":"2024013019064554700_bib19","doi-asserted-by":"crossref","first-page":"19934","DOI":"10.1016\/S0021-9258(19)47201-3","article-title":"Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin, and type I collagen mRNA levels in ROS\/17.2 cells","volume":"264","author":"Rodan","year":"1989","journal-title":"J Biol Chem"},{"key":"2024013019064554700_bib20","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1359\/jbmr.1998.13.4.645","article-title":"The effects of fibroblast growth factor-2 on human neonatal calvaria osteoblastic cells are differentiation stage specific","volume":"13","author":"Debiais","year":"1998","journal-title":"J Bone Miner Res"},{"key":"2024013019064554700_bib21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S8756-3282(98)00087-8","article-title":"Basic fibroblast growth factor enhances the growth and expression of the osteogenic phenotype of dexamethasone-treated human bone marrow-derived bone-like cells in culture","volume":"23","author":"Pri-Chen","year":"1998","journal-title":"Bone"},{"key":"2024013019064554700_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s002239900581","article-title":"Basic fibroblast growth factor in the presence of dexamethasone stimulates colony formation, expansion, and osteoblastic differentiation by rat bone marrow stromal cells","volume":"64","author":"Scutt","year":"1999","journal-title":"Calcif Tissue Int"},{"key":"2024013019064554700_bib23","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/bbrc.1999.1601","article-title":"Basic fibroblast growth factor induces osteoclast formation by reciprocally regulating the production of osteoclast differentiation factor and osteoclastogenesis inhibitory factor in mouse osteoblastic cells","volume":"265","author":"Nakagawa","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"2024013019064554700_bib24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/(SICI)1097-4652(199608)168:2<395::AID-JCP18>3.0.CO;2-2","article-title":"Basic fibroblast growth factor inhibits osteoclast-like cell formation","volume":"168","author":"Jimi","year":"1996","journal-title":"J Cell Physiol"},{"key":"2024013019064554700_bib25","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1359\/jbmr.2000.15.3.466","article-title":"Direct and indirect actions of fibroblast growth factor 2 on osteoclastic bone resorption in cultures","volume":"15","author":"Kawaguchi","year":"2000","journal-title":"J Bone Miner Res"},{"key":"2024013019064554700_bib26","doi-asserted-by":"crossref","first-page":"31444","DOI":"10.1074\/jbc.M910132199","article-title":"Fibroblast growth factor (FGF)-2 directly stimulates mature osteoclast function through activation of FGF receptor 1 and p42\/p44 MAP kinase","volume":"275","author":"Chikazu","year":"2000","journal-title":"J Biol Chem"},{"key":"2024013019064554700_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S8756-3282(97)00292-5","article-title":"Basic fibroblast growth factor induces osteoclast formation in murine bone marrow cultures","volume":"22","author":"Hurley","year":"1998","journal-title":"Bone"},{"key":"2024013019064554700_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S8756-3282(00)00312-4","article-title":"Anabolic effects of basic fibroblast growth factor in the tibial diaphysis of ovariectomized rats","volume":"27","author":"Pun","year":"2000","journal-title":"Bone"},{"key":"2024013019064554700_bib29","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s002239900563","article-title":"Local application of basic fibroblast growth factor minipellet induces the healing of segmental bony defects in rabbits","volume":"63","author":"Inui","year":"1998","journal-title":"Calcif Tissue Int"},{"key":"2024013019064554700_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s002640050207","article-title":"Stimulation of bone formation by intraosseous injection of basic fibroblast growth factor in ovariectomised rats","volume":"22","author":"Nakamura","year":"1998","journal-title":"Int Orthop"},{"key":"2024013019064554700_bib31","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1210\/endo.140.12.7195","article-title":"Bone anabolic effects of basic fibroblast growth factor in ovariectomized rats","volume":"140","author":"Liang","year":"1999","journal-title":"Endocrinology"},{"key":"2024013019064554700_bib32","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S8756-3282(00)00423-3","article-title":"Decreased bone anabolic effect of basic fibroblast growth factor at fatty marrow sites in ovariectomized rats","volume":"28","author":"Pun","year":"2001","journal-title":"Bone"},{"key":"2024013019064554700_bib33","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1359\/jbmr.1998.13.6.942","article-title":"Recombinant human basic fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fracture","volume":"13","author":"Nakamura","year":"1998","journal-title":"J Bone Miner Res"},{"key":"2024013019064554700_bib34","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0003-4975(00)01645-3","article-title":"Basic fibroblast growth factor may improve devascularized sternal healing","volume":"70","author":"Iwakura","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"2024013019064554700_bib35","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1359\/jbmr.1999.14.6.953","article-title":"Systemic administration of acidic fibroblast growth factor (FGF-1) prevents bone loss and increases new bone formation in ovariectomized rats","volume":"14","author":"Dunstan","year":"1999","journal-title":"J Bone Miner Res"},{"key":"2024013019064554700_bib36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S8756-3282(99)00193-3","article-title":"Anabolic effect of aminoterminally truncated fibroblast growth factor 4 (FGF4) on bone","volume":"25","author":"Kuroda","year":"1999","journal-title":"Bone"},{"key":"2024013019064554700_bib37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1097-0029(19980515)41:4<313::AID-JEMT4>3.0.CO;2-R","article-title":"Morphological examination of bone synthesis via direct administration of basic fibroblast growth factor into rat bone marrow","volume":"41","author":"Amizuka","year":"1998","journal-title":"Microsc Res Tech"},{"key":"2024013019064554700_bib38","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/rheumatology\/38.8.714","article-title":"Involvement of fibroblast growth factor-2 in joint destruction of rheumatoid arthritis patients","volume":"38","author":"Manabe","year":"1999","journal-title":"Rheumatology"},{"key":"2024013019064554700_bib39","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/jcb.240550306","article-title":"Role of vascular endothelial cells in bone biology","volume":"55","author":"Collin-Osdoby","year":"1994","journal-title":"J Cell Biochem"},{"key":"2024013019064554700_bib40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/9467","article-title":"VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation","volume":"5","author":"Gerber","year":"1999","journal-title":"Nat Med"},{"key":"2024013019064554700_bib41","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/1529-0131(199806)41:6<951::AID-ART2>3.0.CO;2-D","article-title":"Angiogenesis: Implications for rheumatoid arthritis","volume":"41","author":"Koch","year":"1998","journal-title":"Arthrit Rheum"},{"key":"2024013019064554700_bib42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-0757.1997.tb00196.x","article-title":"Mechanisms of alveolar bone destruction in periodontitis","volume":"14","author":"Schwartz","year":"1998","journal-title":"Periodontol 2000"},{"key":"2024013019064554700_bib43","first-page":"729","article-title":"Dynamics of bone remodeling: Biochemical and pathophysiological basis","volume":"34","author":"de Vernejoul","year":"1996","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"2024013019064554700_bib44","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1096\/fasebj.11.5.9141503","article-title":"Vascular development: Cellular and molecular regulation","volume":"11","author":"Beck","year":"1997","journal-title":"FASEB J"},{"key":"2024013019064554700_bib45","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1083\/jcb.141.7.1659","article-title":"Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: An autocrine mechanism contributing to angiogenesis","volume":"141","author":"Seghezzi","year":"1998","journal-title":"J Cell Biol"},{"key":"2024013019064554700_bib46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1091\/mbc.10.2.313","article-title":"Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: Biochemical characterization and biological consequences in endothelial cell cultures","volume":"10","author":"Rusnati","year":"1999","journal-title":"Mol Biol Cell"},{"key":"2024013019064554700_bib47","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/art.1780360204","article-title":"The adhesion molecules of inflammation","volume":"36","author":"Cronstein","year":"1993","journal-title":"Arthritis Rheum"},{"key":"2024013019064554700_bib48","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"2024013019064554700_bib49","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jcp.1041620206","article-title":"In vitro structural and functional relationships between preosteoclastic and bone endothelial cells: A juxtacrine model for migration and adhesion of osteoclast precursors","volume":"162","author":"Formigli","year":"1995","journal-title":"J Cell Physiol"},{"key":"2024013019064554700_bib50","doi-asserted-by":"crossref","first-page":"20659","DOI":"10.1074\/jbc.M010153200","article-title":"Receptor activator of NF-kB ligand and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis","volume":"276","author":"Collin-Osdoby","year":"2001","journal-title":"J Biol Chem"},{"key":"2024013019064554700_bib51","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1359\/jbmr.2000.15.3.474","article-title":"Decreased nitric oxide levels stimulate osteoclastogenesis and bone resorption both in vitro and in vivo on the chick chorioallantoic membrane in association with neoangiogenesis","volume":"15","author":"Collin-Osdoby","year":"2000","journal-title":"J Bone Miner Res"},{"key":"2024013019064554700_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jbmr.5650100109","article-title":"Osteoclast 121F antigen expression during osteoblast conditioned medium induction of osteoclast-like cells in vitro: Relationship to calcitonin responsiveness, tartrate resistant acid phosphatase levels, and bone resorptive activity","volume":"10","author":"Collin-Osdoby","year":"1995","journal-title":"J Bone Miner Res"},{"key":"2024013019064554700_bib53","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"2024013019064554700_bib54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1152\/jappl.1999.86.1.313","article-title":"Expression of fibroblast growth factor family during postnatal skeletal muscle hypertrophy","volume":"86","author":"Mitchell","year":"1999","journal-title":"J Appl Physiol"},{"key":"2024013019064554700_bib55","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat Med"},{"key":"2024013019064554700_bib56","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4049\/jimmunol.168.1.450","article-title":"Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats","volume":"168","author":"Yamashita","year":"2002","journal-title":"J Immunol"},{"key":"2024013019064554700_bib57","first-page":"308","article-title":"Advances in bone biology: The osteoclast","volume":"17","author":"Roodman","year":"1996","journal-title":"Endocr Rev"},{"key":"2024013019064554700_bib58","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/stem.5530100404","article-title":"Cytokines and local factors which affect osteoclast function","volume":"10","author":"Mundy","year":"1992","journal-title":"Int J Cell Cloning"},{"key":"2024013019064554700_bib59","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/mvre.1996.1993","article-title":"Basic fibroblast growth factor-induced angiogenesis in the chick embryo chorioallantoic membrane: An electron microscopy study","volume":"53","author":"Ribatti","year":"1997","journal-title":"Microvasc Res"},{"key":"2024013019064554700_bib60","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/01.ATV.20.5.1250","article-title":"Fibroblast growth factor-2 selectively stimulates angiogenesis of small vessels in arterial trees","volume":"20","author":"Parsons-Wingerter","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024013019064554700_bib61","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1126\/science.270.5241.1500","article-title":"Definition of two angiogenic pathways by distinct alpha v integrins","volume":"270","author":"Friedlander","year":"1995","journal-title":"Science"},{"key":"2024013019064554700_bib62","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1083\/jcb.140.5.1255","article-title":"Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis","volume":"140","author":"Eliceiri","year":"1998","journal-title":"J Cell Biol"},{"key":"2024013019064554700_bib63","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1096\/fasebj.14.1.137","article-title":"Differential ability of heparin sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ","volume":"14","author":"Chang","year":"2000","journal-title":"FASEB J"},{"key":"2024013019064554700_bib64","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/(SICI)1097-0185(20000501)259:1<97::AID-AR11>3.0.CO;2-O","article-title":"Osteogenic protein-1, a bone morphogenetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor-\u03b21","volume":"259","author":"Ramoshebi","year":"2000","journal-title":"Anat Rec"},{"key":"2024013019064554700_bib65","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1006\/bbrc.1998.9875","article-title":"Basic fibroblast growth factor induces cyclooxygenase-2 expression in endothelial cells derived from bone","volume":"254","author":"Kage","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"2024013019064554700_bib66","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nm1097-1083","article-title":"bFGF and tumor angiogenesis\u2014back in the limelight?","volume":"3","author":"Rak","year":"1997","journal-title":"Nat Med"},{"key":"2024013019064554700_bib67","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/ar292","article-title":"Angiogenesis in the pathogenesis of inflammatory joint and lung diseases","volume":"3","author":"Walsh","year":"2001","journal-title":"Arthritis Res"},{"key":"2024013019064554700_bib68","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0009-9260(97)80253-X","article-title":"Avascular necrosis of bone following an intensified chemotherapy regimen including high dose steroids","volume":"52","author":"Thornton","year":"1997","journal-title":"Clin Radiol"},{"issue":"Suppl","key":"2024013019064554700_bib69","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1097\/00003086-199810001-00010","article-title":"Angiogenesis in fracture repair","volume":"355","author":"Glowacki","year":"1998","journal-title":"Clin Orthop"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1359%2Fjbmr.2002.17.10.1859","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/17\/10\/1859\/56467760\/5650171015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/17\/10\/1859\/56467760\/5650171015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:03:58Z","timestamp":1710342238000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/17\/10\/1859-1871\/7592115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,1]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2009,12,2]]},"published-print":{"date-parts":[[2002,10,1]]}},"URL":"https:\/\/doi.org\/10.1359\/jbmr.2002.17.10.1859","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2002,10,1]]},"published":{"date-parts":[[2002,10,1]]}}}