{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:53:29Z","timestamp":1794020009796,"version":"4.8.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fibrous dysplasia (FD) of bone can be complicated by renal phosphate wasting. The effect of hypophosphatemia on normal and dysplastic bone of FD patients has not been well characterized. In this study, we compared serum phosphorus (sPi) levels to histomorphometric findings in 27 iliac bone samples from 23 children and adolescents (aged 4.2\u201316.4 years) with polyostotic FD. The samples were separated into two groups, based on the presence (n = 10) or absence (n = 17) of a dysplastic lesion within the specimen. Histomorphometric results were compared with those from 18 age-matched control subjects without metabolic bone disease. In dysplastic lesions, trabeculae were clearly thinner and increased in number. Osteoid indices, osteoblast surface per bone surface, and mineralization lag time were elevated in dysplastic areas, but there was no detectable effect of sPi concentrations on these indices. In nondysplastic bone tissue, low sPi levels were associated with mildly increased osteoid thickness and prolonged mineralization lag time. None of the 13 patients in whom hand X-rays were available at the time of biopsy had radiological signs of rickets. In conclusion, low sPi can cause a mild systemic mineralization defect in FD, but the more severe mineralization defect seen in dysplastic lesions is independent of sPi levels. It is debatable whether the mild systemic mineralization defect warrants treatment with oral phosphorus supplementation if signs of rickets are absent.<\/jats:p>","DOI":"10.1359\/jbmr.2002.17.11.1949","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T04:00:07Z","timestamp":1146110407000},"page":"1949-1953","source":"Crossref","is-referenced-by-count":28,"title":["Bone Mineralization in Polyostotic Fibrous Dysplasia: Histomorphometric Analysis"],"prefix":"10.1093","volume":"17","author":[{"given":"Leonieke","family":"Terpstra","sequence":"first","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Rauch","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Plotkin","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Travers","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis H.","family":"Glorieux","sequence":"additional","affiliation":[{"name":"Genetics Unit, Shriners Hospital for Children and McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024013019061044300_bib1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1053\/berh.1999.0071","article-title":"Fibrous dysplasia of bone","volume":"14","author":"Chapurlat","year":"2000","journal-title":"Baillieres Best Pract Res Clin Rheumatol"},{"key":"2024013019061044300_bib2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1359\/jbmr.2001.16.5.806","article-title":"Renal phosphate wasting in fibrous dysplasia of bone is part of a generalized renal tubular dysfunction similar to that seen in tumor-induced osteomalacia","volume":"16","author":"Collins","year":"2001","journal-title":"J Bone Miner Res"},{"key":"2024013019061044300_bib3","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1210\/jcem.80.12.8530601","article-title":"Urinary cyclic adenosine 3\u2032, 5\u2032-monophosphate response in McCune-Albright syndrome: Clinical evidence for altered renal adenylate cyclase activity","volume":"80","author":"Zung","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2024013019061044300_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s007740170012","article-title":"Hypophosphatemic rickets accompanying McCune-Albright syndrome: Evidence that a humoral factor causes hypophosphatemia","volume":"19","author":"Yamamoto","year":"2001","journal-title":"J Bone Miner Metab"},{"key":"2024013019061044300_bib5","first-page":"411","article-title":"Hypophosphataemic osteomalacia in fibrous dysplasia","volume":"45","author":"Dent","year":"1976","journal-title":"Q J Med"},{"key":"2024013019061044300_bib6","first-page":"263","article-title":"A case of McCune-Albright syndrome with hyperthyroidism and vitamin D-resistant rickets","volume":"32","author":"Tanaka","year":"1977","journal-title":"Helv Paediatr Acta"},{"key":"2024013019061044300_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1359\/jbmr.2000.15.1.120","article-title":"Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone","volume":"15","author":"Bianco","year":"2000","journal-title":"J Bone Miner Res"},{"key":"2024013019061044300_bib8","first-page":"645","volume-title":"Vitamin D","author":"Parfitt","year":"1997"},{"key":"2024013019061044300_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S8756-3282(97)00107-5","article-title":"Polymerase chain reaction-based technique for the selective enrichment and analysis of mosaic arg201 mutations in G alpha s from patients with fibrous dysplasia of bone","volume":"21","author":"Candeliere","year":"1997","journal-title":"Bone"},{"key":"2024013019061044300_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S8756-3282(99)00257-4","article-title":"Normative data for iliac bone histomorphometry in growing children","volume":"26","author":"Glorieux","year":"2000","journal-title":"Bone"},{"key":"2024013019061044300_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"key":"2024013019061044300_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1210\/jcem-45-2-299","article-title":"The importance of phosphate in regulating plasma 1, 25-(OH)2-vitamin D levels in humans: Studies in healthy subjects in calcium-stone formers and in patients with primary hyperparathyroidism","volume":"45","author":"Gray","year":"1977","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1359%2Fjbmr.2002.17.11.1949","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/17\/11\/1949\/56467796\/5650171106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/17\/11\/1949\/56467796\/5650171106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:04:05Z","timestamp":1710342245000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/17\/11\/1949-1953\/7592120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,1]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,12,2]]},"published-print":{"date-parts":[[2002,11,1]]}},"URL":"https:\/\/doi.org\/10.1359\/jbmr.2002.17.11.1949","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2002,11,1]]},"published":{"date-parts":[[2002,11,1]]}}}