{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:40:54Z","timestamp":1765608054874},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteopathia has been reported in Wilson disease (WD), but bone density has not been measured; therefore, we performed bone mineral density (BMD), bone mineral content (BMC), and quantitative bone ultrasound (QUS) assessments, as well as measured the serum levels of osteocalcin (OCN), \u03b2-cross-laps (\u03b2-CTx's), and the recently discovered osteoprotegerin (OPG) and its ligand RANKL to investigate the underlying mechanism of osseous disorders. Serum OCN, \u03b2-CTx, OPG, and RANKL levels were measured by ELISA in 21 WD patients and in 20 age- and gender-matched healthy subjects. BMD, BMC, and QUS parameters were also determined. Osteoporosis was present in 9\/21 (43%) WD patients. Abnormal QUS parameters were found in 7 (33%) of the patients. Although serum OCN levels were similar in patients and controls (29.93 \u00b1 24.65 mg\/ml vs. 29.84 \u00b1 6.89 mg\/ml), \u03b2-CTx and OPG levels were significantly increased in WD compared with the healthy controls (625.4 \u00b1 312.3 pg\/ml vs. 423.6 \u00b1 144.3 pg\/ml and p = 0.022 and 7.2 \u00b1 3.4 pM vs. 3.5 \u00b1 1.0 pM and p &amp;lt; 0.001, respectively). No difference was observed in the RANKL level. There was a positive correlation between OCN and \u03b2-CTx (r = 0.55; p = 0.01). We proved high occurrence of osteoporosis in WD. Negative bone remodeling balance is a consequence of increased bone resorption, which is indicated by elevated \u03b2-CTx. The novel finding of elevated serum OPG may reflect a compensatory reaction to enhanced osteoclast activity, despite the normal OCN level.<\/jats:p>","DOI":"10.1359\/jbmr.2002.17.11.1961","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T04:00:07Z","timestamp":1146110407000},"page":"1961-1967","source":"Crossref","is-referenced-by-count":60,"title":["Decreased Bone Density, Elevated Serum Osteoprotegerin, and \u03b2-Cross-Laps in Wilson Disease"],"prefix":"10.1093","volume":"17","author":[{"given":"D.","family":"Hegedus","sequence":"first","affiliation":[{"name":"First Department of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Ferencz","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"Lakatos","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Meszaros","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lakatos","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Horvath","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Szalay","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Semmelweis University, Budapest, 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