{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T22:05:48Z","timestamp":1782770748758,"version":"3.54.5"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The purpose of this population-based prospective cohort study was to examine the effect of hormone-replacement therapy (HRT) on the risk of fractures. The study population consisted of 7217 postmenopausal women aged 47-56 years (mean, 53.3 years) at baseline from data taken from the Kuopio Osteoporosis Risk Factor and Prevention Study (OSTPRE) in Finland. We compared fracture incidences between HRT users and nonusers. A total of 679 (9.4%) women recorded validated fractures during the 5-year follow-up. Of these, 268 (39%) women had a distal forearm fracture. Two thousand six hundred seventy women (37%) had used HRT &amp;gt;6 months during the follow-up\u2014one-half of them continuously. The relative risk, estimated as hazard ratio with Cox regression, was 0.69 (95% CI, 0.58-0.82) for any fracture and 0.49 (0.36-0.66) for distal forearm fracture among HRT users as compared with never-users. After adjusting for age, body mass index (BMI), number of chronic health disorders, fracture history, and time since menopause (independent risk factors) the corresponding risks were 0.67 (0.55-0.81) and 0.53 (0.37-0.74), respectively. The respective adjusted risks for continuous HRT users were 0.62 (0.48-0.79) and 0.41 (0.26-0.67). The adjusted risk of other than distal forearm fracture was 0.74 (0.55-0.98). The results suggest that HRT has a beneficial effect on prevention of fractures in general and on that of distal forearm fracture in particular in early postmenopausal women.<\/jats:p>","DOI":"10.1359\/jbmr.2002.17.3.528","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T05:08:32Z","timestamp":1146114512000},"page":"528-533","source":"Crossref","is-referenced-by-count":43,"title":["Does Hormone-Replacement Therapy Prevent Fractures in Early Postmenopausal Women?"],"prefix":"10.1093","volume":"17","author":[{"given":"Kaisa M.","family":"Randell","sequence":"first","affiliation":[{"name":"Research Institute of Public Health, University of Kuopio, Kuopio, Finland"},{"name":"Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto J.","family":"Honkanen","sequence":"additional","affiliation":[{"name":"Research Institute of Public Health, University of Kuopio, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Saarikoski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kuopio University Hospital, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024013019102811100_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0140-6736(81)91848-1","article-title":"Bone mass in postmenopausal women after withdrawal of oestrogen\/gestagen replacement therapy","volume":"1","author":"Christiansen","year":"1981","journal-title":"Lancet"},{"key":"2024013019102811100_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-117-1-1","article-title":"Treatment of postmenopausal osteoporosis with transdermal estrogen","volume":"117","author":"Lufkin","year":"1992","journal-title":"Ann Intern Med"},{"key":"2024013019102811100_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01623453","article-title":"Who are candidates for prevention and treatment for osteoporosis? 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