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We compared the effects of the isoflavone daidzein, which has no action on tyrosine kinases, and 17\u03b2-estradiol on the development and activity of osteoclasts in vitro. Nonadherent porcine bone marrow cells were cultured on dentine slices or on culture slides in the presence of 10\u22128 M of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], with or without 10\u22128 M of daidzein, 10\u22128 M of 17\u03b2-estradiol for 9-11 days. Multinucleated tartrate-resistant acid phosphatase-positive (TRAP+) cells that resorbed bone (osteoclasts) developed in the presence of 1,25(OH)2D3. The number of osteoclasts formed in response to 1,25(OH)2D3 was reduced by 58 \u00b1 8% by daidzein and 52 \u00b1 5% by estrogen (p &amp;lt; 0.01); these effects were reversed by 10\u22126 M of ICI 182,780. The area resorbed by mature osteoclasts was reduced by 39 \u00b1 5% by daidzein and 42 \u00b1 6% by estradiol (p &amp;lt; 0.01). Both compounds also inhibited the 1,25(OH)2D3-induced differentiation of osteoclast progenitors (mononucleated TRAP+ cells), 53 \u00b1 8% by daidzein and 50 \u00b1 7% by estradiol (p &amp;lt; 0.05). Moreover, daidzein and estradiol promoted caspase-8 and caspase-3 cleavage and DNA fragmentation of monocytic bone marrow cells. Caspase-3 cleavage was reversed by 10\u22128 M of ICI 182,780. Both compounds up-regulated the expression of nuclear estrogen receptors ER-\u03b1 and ER-\u03b2. Thus, daidzein, at the same concentration as 17\u03b2-estradiol, inhibits osteoclast differentiation and activity. This may be caused by, at least in part, greater apoptosis of osteoclast progenitors mediated by ERs.<\/jats:p>","DOI":"10.1359\/jbmr.2002.17.4.630","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T04:55:16Z","timestamp":1146113716000},"page":"630-638","source":"Crossref","is-referenced-by-count":76,"title":["Down-Regulation of Osteoclast Differentiation by Daidzein via Caspase 3"],"prefix":"10.1093","volume":"17","author":[{"given":"Claudia Maria","family":"Rassi","sequence":"first","affiliation":[{"name":"CNRS UPR 1524, Jouy en Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Lieberherr","sequence":"additional","affiliation":[{"name":"CNRS UPR 1524, Jouy en Josas, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Chaumaz","sequence":"additional","affiliation":[{"name":"LNSA, INRA, Jouy en Josas, 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