{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:33:48Z","timestamp":1779878028218,"version":"3.53.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alveolar bone resorption by osteoclasts is essential for tooth eruption. Osteoclast-deficient Csfmop homozygous (op\/op) mice, which lack functional macrophage colony-stimulating factor (M-CSF), suffer from osteopetrosis and completely lack tooth eruption. Although osteoclasts appear, and osteopetrosis is cured with age in op\/op mice, tooth eruption is never seen. This fact suggests that there is a critical period when osteoclasts are required for tooth eruption. In this study, to detect the critical period, we administered an antagonistic antibody directed against c-Fms, a receptor for M-CSF, to inbred C57BL\/6 mice for various periods. Administration of this antibody decreased tartrate-resistant acid phosphatase-positive (TRAP) osteoclasts, and incisor eruption was completely inhibited by continual administration of this antibody from embryonic day 15.5 (E15.5) until postnatal day 12.5 (D12.5). A 1-day delay of this administration abolished the inhibition of incisor eruption. The number of TRAP-positive osteoclasts was significantly reduced between E16.5 and E18.5 in the mice treated with antibody from E15.5 compared with those treated from E16.5. These results indicate that this period, during which the number of osteoclasts decreases significantly, is critical for inhibiting incisor eruption in C57BL\/6 mice.<\/jats:p>","DOI":"10.1359\/jbmr.2003.18.1.108","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T21:31:36Z","timestamp":1146087096000},"page":"108-116","source":"Crossref","is-referenced-by-count":13,"title":["Reduction of Osteoclasts in a Critical Embryonic Period Is Essential for Inhibition of Mouse Tooth Eruption"],"prefix":"10.1093","volume":"18","author":[{"given":"Miya","family":"Yoshino","sequence":"first","affiliation":[{"name":"Division of Oral and Maxillofacial Biopathological Surgery, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan"},{"name":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisahiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumpei","family":"Niida","sequence":"additional","affiliation":[{"name":"Section of Medical Disorders, Department of Geriatric Research, National Institute for Longevity Science, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ichi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Ryoke","sequence":"additional","affiliation":[{"name":"Division of Oral and Maxillofacial Biopathological Surgery, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kunisada","sequence":"additional","affiliation":[{"name":"Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan"},{"name":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ichi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,2]]},"reference":[{"key":"2024013019165350500_bib1","first-page":"172","article-title":"Osteopetrosis: Multiple pathways for the interception of osteoclast function","volume":"5","author":"Marks","year":"1987","journal-title":"Appl Pathol"},{"key":"2024013019165350500_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-0714.1989.tb00755.x","article-title":"Effects of bone marrow transplantation on impacted dental germs in osteopetrotic op\/op rats","volume":"18","author":"Philippart","year":"1989","journal-title":"J Oral Pathol Med"},{"key":"2024013019165350500_bib3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/283669a0","article-title":"Osteoclast derived from haematopoietic stem cells","volume":"283","author":"Ash","year":"1980","journal-title":"Nature"},{"key":"2024013019165350500_bib4","first-page":"209","volume-title":"Bone Mineral Research","author":"Mundy","year":"1987"},{"key":"2024013019165350500_bib5","first-page":"87","volume-title":"Principles of Bone Biology","author":"Suda","year":"1996"},{"key":"2024013019165350500_bib6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0092-8674(85)80047-7","article-title":"The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor CSF-1","volume":"41","author":"Sherr","year":"1985","journal-title":"Cell"},{"key":"2024013019165350500_bib7","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1084\/jem.173.5.1291","article-title":"Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells","volume":"173","author":"Kodama","year":"1991","journal-title":"J Exp Med"},{"key":"2024013019165350500_bib8","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1073\/pnas.89.20.9637","article-title":"Detection of transcripts for the receptor for macrophage colony-stimulating factor c-fms, in murine osteoclasts","volume":"89","author":"Hofstetter","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024013019165350500_bib9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/(SICI)1097-4652(199703)170:3<241::AID-JCP4>3.0.CO;2-O","article-title":"Osteoclast precursors in bone marrow and peritoneal cavity","volume":"170","author":"Hayashi","year":"1997","journal-title":"J Cell Physiol"},{"key":"2024013019165350500_bib10","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1182\/blood.V90.9.3516","article-title":"Development of osteoclasts from embryonic stem cells though a pathway that is c-fms but not c-kit dependent","volume":"90","author":"Yamane","year":"1997","journal-title":"Blood"},{"key":"2024013019165350500_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/aja.1001380204","article-title":"Pathogenesis of osteopetrosis in the rat: Reduced bone resorption due to reduced osteoclast function","volume":"138","author":"Marks","year":"1973","journal-title":"Am J Anat"},{"key":"2024013019165350500_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/oxfordjournals.jhered.a108657","article-title":"Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse","volume":"67","author":"Marks","year":"1976","journal-title":"J Hered"},{"key":"2024013019165350500_bib13","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1084\/jem.156.5.1516","article-title":"Hematological characterization of congenital osteopetrosis in op\/op mouse. Possible mechanism for abnormal macrophage differentiation","volume":"156","author":"Wiktor-Jedrzejczak","year":"1982","journal-title":"J Exp Med"},{"key":"2024013019165350500_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/path.1711290203","article-title":"A functional assessment of macrophages from osteopetrotic mice","volume":"129","author":"Chambers","year":"1979","journal-title":"J Pathol"},{"key":"2024013019165350500_bib15","first-page":"657","article-title":"Abnormal differentiation of tissue macrophage populations in \u2018osteopetrosis\u2019 (op) mice defective in the production of macrophage colony-stimulating factor","volume":"139","author":"Naito","year":"1991","journal-title":"Am J Pathol"},{"key":"2024013019165350500_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1182\/blood.V86.1.66.bloodjournal86166","article-title":"Granulocyte-macrophage colony-stimulating factor is not responsible for the correction of hematopoietic deficiencies in the maturing op\/op mouse","volume":"86","author":"Nilsson","year":"1995","journal-title":"Blood"},{"key":"2024013019165350500_bib17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/345442a0","article-title":"The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene","volume":"345","author":"Yoshida","year":"1990","journal-title":"Nature"},{"key":"2024013019165350500_bib18","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","article-title":"Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse","volume":"87","author":"Wiktor-Jedrzejczak","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024013019165350500_bib19","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1210\/endo-127-5-2592","article-title":"Macrophage colony stimulating factor restores in vivo bone resorption in the op\/op osteopetrotic mouse","volume":"127","author":"Felix","year":"1990","journal-title":"Endocrinology"},{"key":"2024013019165350500_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.173.1.269","article-title":"Congenital osteoclast deficiency in osteopetrotic (op\/op) mice is cured by injections of macrophage colony-stimulating factor","volume":"173","author":"Kodama","year":"1991","journal-title":"J Exp Med"},{"key":"2024013019165350500_bib21","first-page":"1049","article-title":"Correction by CSF-1 of defects in the osteopetrotic op\/op mouse suggests local, developmental, and humoral requirements for this growth factor","volume":"19","author":"Wiktor-Jedrzejczak","year":"1991","journal-title":"Exp Hematol"},{"key":"2024013019165350500_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1538\/expanim.46.95","article-title":"Restoration of disturbed tooth eruption in osteopetrotic (op\/op) mice by injection of macrophage colony-stimulating factor","volume":"46","author":"Niida","year":"1997","journal-title":"Exp Anim"},{"key":"2024013019165350500_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1084\/jem.177.1.237","article-title":"Delayed hematopoietic development in osteopetrotic (op\/op) mice","volume":"177","author":"Begg","year":"1993","journal-title":"J Exp Med"},{"key":"2024013019165350500_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1084\/jem.190.2.293","article-title":"Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption","volume":"190","author":"Niida","year":"1999","journal-title":"J Exp Med"},{"key":"2024013019165350500_bib25","first-page":"2469","article-title":"Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M","volume":"11","author":"Sudo","year":"1995","journal-title":"Oncogene"},{"key":"2024013019165350500_bib26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF02411252","article-title":"Bone acid phosphatase: Tartrate-resistant acid phosphatase as a marker of osteoclast function","volume":"34","author":"Minkin","year":"1982","journal-title":"Calcif Tissue Int"},{"key":"2024013019165350500_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/35.2.3540104","article-title":"Tartrate-resistant acid phosphatase in bone and cartilage following decalcification and cold-embedding in plastic","volume":"35","author":"Cole","year":"1987","journal-title":"J Histochem Cytochem"},{"key":"2024013019165350500_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1084\/jem.174.1.63","article-title":"Expression and function of c-kit in hemopoietic progenitor cells","volume":"174","author":"Ogawa","year":"1991","journal-title":"J Exp Med"},{"key":"2024013019165350500_bib29","first-page":"227","volume-title":"The Mouse","author":"Rugh","year":"1990"},{"key":"2024013019165350500_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1600-0714.1980.tb00377.x","article-title":"Tooth eruption: Evidence for the central role of the dental follicle","volume":"9","author":"Cahill","year":"1980","journal-title":"J Oral Pathol"},{"key":"2024013019165350500_bib31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-0714.1987.tb02060.x","article-title":"Regional control by the dental follicle of alterations in alveolar bone metabolism during tooth eruption","volume":"16","author":"Marks","year":"1987","journal-title":"J Oral Pathol"},{"key":"2024013019165350500_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s002239900657","article-title":"Dental abnormalities associated with failure of tooth eruption in src knockout and op\/op mice","volume":"65","author":"Tiffee","year":"1999","journal-title":"Calcif Tissue Int"},{"key":"2024013019165350500_bib33","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.178.5.1733","article-title":"Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts","volume":"178","author":"Fuller","year":"1993","journal-title":"J Exp Med"},{"key":"2024013019165350500_bib34","first-page":"495","volume-title":"The Atlas of Mouse Development","author":"Kaufman","year":"1992"},{"key":"2024013019165350500_bib35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0003-9969(98)00019-3","article-title":"Confocal laser scanning and microscopic study of tartrate-resistant acid phosphatase-positive cells in the dental follicle during early morphogenesis of mouse embryonic molar teeth","volume":"43","author":"Sakakura","year":"1998","journal-title":"Arch Oral Biol"},{"key":"2024013019165350500_bib36","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o98-099","article-title":"Commitment and differentiation of stem cells to the osteoclast lineage","volume":"76","author":"Hayashi","year":"1998","journal-title":"Biochem Cell Biol"},{"key":"2024013019165350500_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/8756-3282(92)90365-4","article-title":"Administration of colony stimulating factor-1 corrects some macrophage, dental, and skeletal defects in an osteopetrotic mutation (Toothless, tl) in the rat","volume":"13","author":"Marks","year":"1992","journal-title":"Bone"},{"key":"2024013019165350500_bib38","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0003-9969(92)90125-R","article-title":"The effects of colony-stimulating factor-1 on tooth eruption in the toothless (osteopetrotic) rat in relation to the critical periods for bone resorption during tooth eruption","volume":"37","author":"Iizuka","year":"1992","journal-title":"Arches Oral Biol"},{"key":"2024013019165350500_bib39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jbmr.5650080107","article-title":"Transient recruitment of osteoclasts and expression of their function in osteopetrotic (op\/op) mice by a single injection of macrophage colony-stimulating factor","volume":"8","author":"Kodama","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2024013019165350500_bib40","first-page":"437","article-title":"The effect of 8-Azaguanine on physiological growth measured by the rate of the eruption of the incisor of the mouse","volume":"11","author":"Meyer","year":"1951","journal-title":"Cancer Res"},{"key":"2024013019165350500_bib41","first-page":"397","volume-title":"Noyes' Oral Histology and Embryology","author":"Noyes","year":"1960"},{"key":"2024013019165350500_bib42","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/00220345670460021201","article-title":"Histology of the mouse incisor","volume":"46","author":"Coady","year":"1967","journal-title":"J Dent Res"},{"key":"2024013019165350500_bib43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/00220345980770011201","article-title":"Inhibition of tooth eruption in the rat by a bisphosphonate","volume":"77","author":"Grier","year":"1998","journal-title":"J Dent Res"},{"key":"2024013019165350500_bib44","first-page":"223","article-title":"The mechanisms and mediators of tooth eruption\u2014models for developmental biologists","volume":"39","author":"Marks","year":"1995","journal-title":"Int J Dev Biol"},{"key":"2024013019165350500_bib45","first-page":"1711","article-title":"Monocyte recruitment and expression of monocyte chemoattractant protein-1 are developmentally regulated in remodeling bone in the mouse","volume":"150","author":"Volejnikova","year":"1997","journal-title":"Am J Pathol"},{"key":"2024013019165350500_bib46","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1046\/j.0909-8836.1999.eos107610.x","article-title":"Gene expression of potential tooth eruption molecules in the dental follicle of the mouse","volume":"107","author":"Wise","year":"1999","journal-title":"Eur J Oral Sci"},{"key":"2024013019165350500_bib47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood.V99.1.111","article-title":"Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects","volume":"99","author":"Dai","year":"2002","journal-title":"Blood"},{"key":"2024013019165350500_bib48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/8756-3282(95)80009-F","article-title":"Colony stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) mice","volume":"16","author":"Sundquist","year":"1995","journal-title":"Bone"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1359%2Fjbmr.2003.18.1.108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/18\/1\/108\/56471774\/5650180114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/18\/1\/108\/56471774\/5650180114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T15:05:41Z","timestamp":1710342341000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/18\/1\/108-116\/7592557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,1]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,12,2]]},"published-print":{"date-parts":[[2003,1,1]]}},"URL":"https:\/\/doi.org\/10.1359\/jbmr.2003.18.1.108","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,1,1]]},"published":{"date-parts":[[2003,1,1]]}}}