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Opt."],"published-print":{"date-parts":[[2020,7,10]]},"abstract":"<jats:p>Using laser excitation, expression microdissection (xMD) can\n\t\t\t\t\tselectively heat cancer cells targeted via immunohistochemical\n\t\t\t\t\tstaining to enable their selective retrieval from tumor tissue\n\t\t\t\t\tsamples, thus reducing misdiagnoses caused by contamination of\n\t\t\t\t\tnoncancerous cells. Several theoretical models have been validated for\n\t\t\t\t\tthe photothermal effect in highly light absorbing and scattering\n\t\t\t\t\tmedia. However, these models are not generally applicable to the\n\t\t\t\t\tphysics behind the process of xMD. In this study, we propose a thermal\n\t\t\t\t\tmodel that can analyze the transient temperature distribution and heat\n\t\t\t\t\tmelt zone in an xMD sample medium composed of a thermoplastic film and\n\t\t\t\t\ta tumor tissue sample sandwiched between two glass slides.\n\t\t\t\t\tFurthermore, we experimentally examined the model using an ink layer\n\t\t\t\t\twith controllable optical properties to serve as a microscale-thin,\n\t\t\t\t\ttissue-mimicking phantom and found the experimentally measured film\n\t\t\t\t\ttemperature is in good agreement with the model predictions. The\n\t\t\t\t\tvalidated model can help researchers to optimize cell retrieval by xMD\n\t\t\t\t\tfor improved diagnostics of cancer and other diseases.<\/jats:p>","DOI":"10.1364\/ao.395864","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T17:01:03Z","timestamp":1591117263000},"page":"5870","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mathematical modeling and experimental validation for expression\n\t\t\t\tmicrodissection"],"prefix":"10.1364","volume":"59","author":[{"given":"Chang-Mu","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edo","family":"Waks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"285","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"ao-59-20-5870-R1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/labinvest.2017.31","volume":"97","author":"Grafen","year":"2017","journal-title":"Lab. 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