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Opt."],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"<jats:p>This study examines the local transmission of normal and pathological corneal tissues when exposed to coherent collimated near-infrared (NIR) radiation with a wavelength of 1061\u00a0nm, highlighting its potential advantages over ultraviolet (UV) radiation for antimicrobial photodynamic therapy (PDT). The proposed measurement method, which employs an original experimental setup with a collimated NIR laser source and a probe fiber for direct layer-by-layer depth profiling, allows for determining the transmission values at specific depths within the cornea. Considering that the affected areas are localized within 1\/3 to 1\/2 of the corneal thickness, the residual power of the NIR radiation in the posterior part of the affected zone (at a depth of 250\u2013400\u00a0\u00b5m) does not exceed 20%. However, the residual power of the NIR radiation at the posterior epithelium of the affected cornea, after passing through its entire thickness, does not exceed 10%. Current UV-based antimicrobial corneal PDT suffers from limited depth penetration and low specificity, hindering effective treatment and requiring photoprotectors to shield the non-regenerating posterior epithelium. NIR-based PDT, using selective photosensitizers, offers a promising alternative. 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