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Opt."],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>\n                    In this work, we propose an eye-shaped microring resonator (E-SMRR)-based photonic biosensor on a silicon-on-insulator (SOI) substrate. The device is modeled using variational finite-difference time-domain (Var FDTD) simulations. Furthermore, the Mason\u2019s gain rule is employed to analytically determine the optical transfer function for the drop port of the E-SMRR system. The proposed E-SMRR biosensor offers a bulk sensitivity of 460.829\u00a0nm\/RIU, an FSR of 27.535\u00a0nm, a quality factor of 1070.677, and a figure of merit equal to 341.308. Additionally, the device has been evaluated for its ability to detect the anemia by assessment of varying hemoglobin concentrations, demonstrating a significant shift in resonant wavelength with a high sensitivity of 7.378\u00d710\n                    <jats:sup>\u22122<\/jats:sup>\n                    nm\/gL\n                    <jats:sup>\u22121<\/jats:sup>\n                    and an intrinsic limit of detection (iLOD) of 4.325\u00d710\n                    <jats:sup>\u22123<\/jats:sup>\n                    RIU. Thus, the design of the proposed E-SMRR biosensor on the SOI substrate is promising for the development of futuristic on-chip optical biosensors.\n                  <\/jats:p>","DOI":"10.1364\/ao.605202","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:00:07Z","timestamp":1789390807000},"page":"9948","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silicon-on-insulator-based eye-shaped microring resonator for label-free detection of anemia"],"prefix":"10.1364","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8735-8342","authenticated-orcid":true,"given":"Shalni","family":"Srivastava","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04bfs6764","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh K.","family":"Tiwari","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04bfs6764","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-0422","authenticated-orcid":true,"given":"Vinod","family":"Parmar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04bfs6764","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Academy of Scientific and Innovative Research (AcSIR)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"ao-65-28-9948-R1","doi-asserted-by":"publisher","first-page":"1390052","DOI":"10.3389\/fonc.2024.1390052","type":"journal-article","volume":"14","author":"Wassie","year":"2024","journal-title":"Front. 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