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Opt. Express"],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p>This paper addresses retinal vessel segmentation on <jats:italic>optical\n\t\t\t\t\tcoherence tomography angiography<\/jats:italic> (OCT-A) images of the human\n\t\t\t\t\tretina. Our approach is motivated by the need for high precision\n\t\t\t\t\timage-guided delivery of regenerative therapies in vitreo-retinal\n\t\t\t\t\tsurgery. OCT-A visualizes macular vasculature, the main landmark of\n\t\t\t\t\tthe surgically targeted area, at a level of detail and spatial extent\n\t\t\t\t\tunattainable by other imaging modalities. Thus, automatic extraction\n\t\t\t\t\tof detailed vessel maps can ultimately inform surgical planning. We\n\t\t\t\t\taddress the task of delineation of the <jats:italic>Superficial Vascular\n\t\t\t\t\tPlexus<\/jats:italic> in 2D Maximum Intensity Projections (MIP) of OCT-A\n\t\t\t\t\tusing convolutional neural networks that iteratively refine the\n\t\t\t\t\tquality of the produced vessel segmentations. We demonstrate that the\n\t\t\t\t\tproposed approach compares favourably to alternative network baselines\n\t\t\t\t\tand graph-based methodologies through extensive experimental analysis,\n\t\t\t\t\tusing data collected from 50 subjects, including both individuals that\n\t\t\t\t\tunderwent surgery for structural macular abnormalities and healthy\n\t\t\t\t\tsubjects. Additionally, we demonstrate generalization to 3D\n\t\t\t\t\tsegmentation and narrower field-of-view OCT-A. In the future, the\n\t\t\t\t\textracted vessel maps will be leveraged for surgical planning and\n\t\t\t\t\tsemi-automated intraoperative navigation in vitreo-retinal\n\t\t\t\t\tsurgery.<\/jats:p>","DOI":"10.1364\/boe.384919","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T12:30:09Z","timestamp":1582029009000},"page":"2490","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Deep iterative vessel segmentation in OCT angiography"],"prefix":"10.1364","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9500-7085","authenticated-orcid":true,"given":"Theodoros","family":"Pissas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.","name":"copyright","label":"Copyright"}]}}