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Opt. Express"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p>The development of a multimodal optical imaging system is presented\n\t\t\t\t\tthat integrates endogenous fluorescence and diffuse reflectance\n\t\t\t\t\tspectroscopy with single-wavelength spatial frequency domain imaging\n\t\t\t\t\t(SFDI) and surface profilometry. The system images specimens at\n\t\t\t\t\tvisible wavelengths with a spatial resolution of 70 \u00b5m, a field\n\t\t\t\t\tof view of 25 cm<jats:sup>2<\/jats:sup> and a depth of field of \u223c1.5 cm.\n\t\t\t\t\tThe results of phantom experiments are presented demonstrating the\n\t\t\t\t\tsystem retrieves absorption and reduced scattering coefficient maps\n\t\t\t\t\tusing SFDI with &lt;6% reconstruction errors. A phase-shifting\n\t\t\t\t\tprofilometry technique is implemented and the resulting 3-D surface\n\t\t\t\t\tused to compute a geometric correction ensuring optical properties\n\t\t\t\t\treconstruction errors are maintained to &lt;6% in curved media\n\t\t\t\t\twith height variations &lt;20 mm. Combining SFDI-computed optical\n\t\t\t\t\tproperties with data from diffuse reflectance spectra is shown to\n\t\t\t\t\tcorrect fluorescence using a model based on light transport in tissue\n\t\t\t\t\ttheory. The system is used to image a human prostate, demonstrating\n\t\t\t\t\tits ability to distinguish prostatic tissue (anterior stroma,\n\t\t\t\t\thyperplasia, peripheral zone) from extra-prostatic tissue (urethra,\n\t\t\t\t\tejaculatory ducts, peri-prostatic tissue). These techniques could be\n\t\t\t\t\tintegrated in robotic-assisted surgical systems to enhance information\n\t\t\t\t\tprovided to surgeons and improve procedural accuracy by minimizing the\n\t\t\t\t\trisk of damage to extra-prostatic tissue during radical prostatectomy\n\t\t\t\t\tprocedures and eventually detect residual cancer.<\/jats:p>","DOI":"10.1364\/boe.388482","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T03:00:06Z","timestamp":1583722806000},"page":"2052","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Wide-field optical spectroscopy system integrating reflectance and spatial frequency domain imaging to measure attenuation-corrected intrinsic tissue fluorescence in radical prostatectomy specimens"],"prefix":"10.1364","volume":"11","author":[{"given":"Emile","family":"Beaulieu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela","family":"Birlea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Sheehy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Angulo-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Latour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roula","family":"Albadine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Trudel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Leblond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"285","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"boe-11-4-2052-R1","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.eururo.2012.02.054","volume":"61","author":"Center","year":"2012","journal-title":"Eur. 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