{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:42:23Z","timestamp":1788964943767,"version":"build-2803163510"},"reference-count":47,"publisher":"Optica Publishing Group","issue":"11","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1364\/OA_License_v1#VOR-OA"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/opg.optica.org\/policies\/opg-tdm-policy.json"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework\n\t\t\t\t\t\tProgramme","doi-asserted-by":"publisher","award":["666295"],"award-info":[{"award-number":["666295"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework\n\t\t\t\t\t\tProgramme","doi-asserted-by":"publisher","award":["713694"],"award-info":[{"award-number":["713694"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework\n\t\t\t\t\t\tProgramme","doi-asserted-by":"publisher","award":["779960"],"award-info":[{"award-number":["779960"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y\n\t\t\t\t\t\tCompetitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["FJC2018-038736-I"],"award-info":[{"award-number":["FJC2018-038736-I"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001870","name":"Fundacja na rzecz Nauki\n\t\t\t\t\t\tPolskiej","doi-asserted-by":"publisher","award":["MAB\/2019\/12"],"award-info":[{"award-number":["MAB\/2019\/12"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["opg.optica.org"],"crossmark-restriction":false},"short-container-title":["Biomed. Opt. Express"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p>Corneal biomechanics play a fundamental role in the genesis and\n\t\t\t\t\tprogression of corneal pathologies, such as keratoconus; in corneal\n\t\t\t\t\tremodeling after corneal surgery; and in affecting the measurement\n\t\t\t\t\taccuracy of glaucoma biomarkers, such as the intraocular pressure\n\t\t\t\t\t(IOP). Air-puff induced corneal deformation imaging reveals\n\t\t\t\t\tinformation highlighting normal and pathological corneal response to a\n\t\t\t\t\tnon-contact mechanical excitation. However, current commercial systems\n\t\t\t\t\tare limited to monitoring corneal deformation only on one corneal\n\t\t\t\t\tmeridian. Here, we present a novel custom-developed swept-source\n\t\t\t\t\toptical coherence tomography (SSOCT) system, coupled with a collinear\n\t\t\t\t\tair-puff excitation, capable of acquiring dynamic corneal deformation\n\t\t\t\t\ton multiple meridians. Backed by numerical simulations of corneal\n\t\t\t\t\tdeformations, we propose two different scan patterns, aided by low\n\t\t\t\t\tcoil impedance galvanometric scan mirrors that permit an appropriate\n\t\t\t\t\tcompromise between temporal and spatial sampling of the corneal\n\t\t\t\t\tdeformation profiles. We customized the air-puff module to provide an\n\t\t\t\t\tunobstructed SSOCT field of view and different peak pressures,\n\t\t\t\t\tair-puff durations, and distances to the eye. We acquired\n\t\t\t\t\tmulti-meridian corneal deformation profiles (a) in healthy human eyes\n\t\t\t\t\t<jats:italic toggle=\"yes\">in vivo<\/jats:italic>, (b) in porcine eyes <jats:italic toggle=\"yes\">ex vivo<\/jats:italic> under varying controlled IOP, and (c) in\n\t\t\t\t\ta keratoconus-mimicking porcine eye <jats:italic toggle=\"yes\">ex\n\t\t\t\t\tvivo<\/jats:italic>. We detected deformation asymmetries, as predicted by\n\t\t\t\t\tnumerical simulations, otherwise missed on a single meridian that will\n\t\t\t\t\tsubstantially aid in corneal biomechanics diagnostics and pathology\n\t\t\t\t\tscreening.<\/jats:p>","DOI":"10.1364\/boe.402402","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T23:30:08Z","timestamp":1600039808000},"page":"6337","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Multi-meridian corneal imaging of air-puff induced deformation for\n\t\t\t\timproved detection of biomechanical abnormalities"],"prefix":"10.1364","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6855-0074","authenticated-orcid":true,"given":"Andrea","family":"Curatolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S.","family":"Birkenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Martinez-Enriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Germann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geethika","family":"Muralidharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Palac\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Eliasy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8622-4632","authenticated-orcid":true,"given":"Ahmed","family":"Abass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u0119drzej","family":"Solarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-5878","authenticated-orcid":true,"given":"Karol","family":"Karnowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Wojtkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elsheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Marcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"boe-11-11-6337-R1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/02713683.2014.914543","volume":"40","author":"Girard","year":"2015","journal-title":"Curr. 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