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Opt. Express"],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:p>Parallel line-field Fourier-domain optical coherence tomography (LF-FDOCT) has emerged to enable relatively higher speeds than the conventional FDOCT system. In the LF-FDOCT, one B-scan is captured at a time instead of scanning the beam to acquire hundreds of A-scans. On the other hand, spectroscopic OCT using the visible waveband provides absorption information over multiple wavelengths at each voxel. This information of spectral absorption enables quantitative measurement of blood oxygenation, voxel by voxel. Here, we presented the design and optimization of a LF-FDOCT system at the visible waveband (520\u2013620\u2005nm), especially using a generic Camera Link area sensor (2048 \u00d7 1088 pixels). To optimize the axial resolution and depth of imaging volume, we simulated various parameters and found that two Nyquist optima can exist, the origin and implication of which has been discussed. As a result, our system acquired 1088 A-scans in parallel at the camera\u2019s frame rate of 281 frame per second, achieving an equivalent rate of over 300,000 A-scan\/s, while minimizing sacrifice in the point spread function (2.8 \u00d7 3.1 \u00d7 3.2 \u00b5m<jats:sup>3<\/jats:sup>, x \u00d7 y \u00d7 z) and the field of view (750 \u00d7 750 \u00d7 750 \u00b5m<jats:sup>3<\/jats:sup>). As an example of application, we presented high-speed imaging of blood oxygenation in the rodent brain cortex.<\/jats:p>","DOI":"10.1364\/boe.413424","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T09:30:06Z","timestamp":1611912606000},"page":"1351","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Design and optimization of line-field optical coherence tomography at visible wavebands"],"prefix":"10.1364","volume":"12","author":[{"given":"Fangjian","family":"Xing","sequence":"first","affiliation":[{"name":"Nanjing Normal University"},{"name":"Brown University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-7995","authenticated-orcid":true,"given":"Jang-Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Brown University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Collin","family":"Polucha","sequence":"additional","affiliation":[{"name":"Brown University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonghwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Brown University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"285","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"boe-12-3-1351-R1","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1016\/j.ophtha.2009.05.025","volume":"116","author":"Tan","year":"2009","journal-title":"Ophthalmology"},{"key":"boe-12-3-1351-R2","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1016\/j.ophtha.2011.01.037","volume":"118","author":"Mohammad","year":"2011","journal-title":"Ophthalmology"},{"key":"boe-12-3-1351-R3","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00403-011-1152-x","volume":"303","author":"Gambichler","year":"2011","journal-title":"Arch. 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