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Opt. Express"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p>Corneal neovascularization (CNV) compromises corneal avascularity and visual acuity. Current clinical visualization approaches are subjective and unable to provide molecular information. Photoacoustic (PA) imaging offers an objective and non-invasive way for angiogenesis investigation through hemodynamic and oxygen saturation level (sO<jats:sub>2<\/jats:sub>) quantification. Here, we demonstrate the utility of PA and slit lamp microscope for <jats:italic>in vivo<\/jats:italic> rat CNV model. PA images revealed untreated corneas exhibited higher sO<jats:sub>2<\/jats:sub> level than treatment groups. The PA results complement with the color image obtained with slit lamp. These data suggest PA could offer an objective and non-invasive method for monitoring CNV progression and treatment outcome through the sO<jats:sub>2<\/jats:sub> quantification.<\/jats:p>","DOI":"10.1364\/boe.423982","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T15:03:16Z","timestamp":1619017396000},"page":"3597","update-policy":"https:\/\/doi.org\/10.1364\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops"],"prefix":"10.1364","volume":"12","author":[{"given":"Kwok-Ho","family":"Lui","sequence":"first","affiliation":[{"name":"The Hong Kong Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Li","sequence":"additional","affiliation":[{"name":"The Hong Kong Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-sum","family":"Lo","sequence":"additional","affiliation":[{"name":"The Hong Kong Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Gu","sequence":"additional","affiliation":[{"name":"The Hong Kong Polytechnic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Tak","family":"Wong","sequence":"additional","affiliation":[{"name":"The Hong Kong Polytechnic University"},{"name":"Hong Kong Polytechnic University Shenzhen Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"285","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"boe-12-6-3597-R1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.survophthal.2012.01.007","volume":"57","author":"Chang","year":"2012","journal-title":"Surv. 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